Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Март 7, 2025

Abstract Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in defense, surveillance, and homeostasis. This review systematically discusses types of hematopoietic progenitors that give rise macrophages, including primitive progenitors, erythro-myeloid stem cells. These have distinct genetic backgrounds developmental processes. Accordingly, macrophages exhibit complex diverse functions body, phagocytosis clearance cellular debris, antigen presentation, response, regulation inflammation cytokine production, tissue remodeling repair, multi-level regulatory signaling pathways/crosstalk involved homeostasis physiology. Besides, tumor-associated a key component TME, exhibiting both anti-tumor pro-tumor properties. Furthermore, functional status is closely linked development various diseases, cancer, autoimmune disorders, cardiovascular disease, neurodegenerative metabolic conditions, trauma. Targeting has emerged as promising therapeutic strategy these contexts. Clinical trials macrophage-based targeted drugs, immunotherapies, nanoparticle-based therapy were comprehensively summarized. Potential challenges future directions targeting also been discussed. Overall, our highlights significance this versatile cell human health which expected inform research clinical practice.

Язык: Английский

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Molecular mechanisms and pathological implications of unconventional protein secretion in human disease: from cellular stress to therapeutic targeting

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Фев. 15, 2025

Язык: Английский

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Integration of transcriptomic and metabolomic analysis reveals light-regulated anthocyanin accumulation in the peel of ‘Yinhongli’ plum

BMC Plant Biology, Год журнала: 2025, Номер 25(1)

Опубликована: Март 27, 2025

The 'Yinhongli' cultivar of Chinese plum (Prunus salicina Lindl.) is characterized by a distinctive bicolored peel phenotype, in which anthocyanins serve as crucial determinants both its visual characteristics and nutritional quality. However, the molecular mechanism underlying light-dependent anthocyanin biosynthesis plum, especially regulatory network pathway, need to be further studied explored. Comprehensive physiological analyses demonstrated distinct pigmentation patterns, revealing that dark-treated (YD) peels retained green coloration, whereas light-exposed (YL) bag-removed samples (YDL) exhibited red pigmentation. Utilizing an integrated approach combining metabolomic transcriptomic analyses, we identified 266 differentially accumulated flavonoids (DAFs), among seven metabolites were established principal coloration. Transcriptomic profiling revealed 6,900 expressed genes (DEGs) between YD YL, demonstrating significant correlations phenylpropanoid flavonoid biosynthetic pathways. Through Weighted Gene Co-expression Network Analysis (WGCNA) correlation heatmap analysis, networks encompassing five structural (PAL, 4CL, F3'H, CHI, UFGT) 15 candidate genes, including six light signal transduction factor (UVR8, COP1, PHYBs, PIF3, HY5) nine transcription (MYB1, MYB20, MYB73, MYB111, LHY, DRE2B, ERF5, bHLH35, NAC87). Subsequent RT-qPCR validation light-mediated up-regulation key F3H, involved along with positive factors (DRE2B Conversely, cohort negative regulators, HY5, MYB1, showed marked down-regulation response exposure, suggesting their potential repressive roles pathway. This investigation provides comprehensive insights into mechanisms identifying critical TFs. findings offer substantial contributions understanding regulation fruit crops provide valuable foundation for breeding initiatives aimed at enhancing quality traits cultivars.

Язык: Английский

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Progress in single-cell sequencing of retinal vein occlusion or ischemic hypoxic retinopathy

Experimental Eye Research, Год журнала: 2025, Номер unknown, С. 110436 - 110436

Опубликована: Май 1, 2025

Язык: Английский

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