Reshaping transcription and translation dynamics during the awakening of the zygotic genome DOI Creative Commons
Louise Maillard, Pierre Bensidoun, Mounia Lagha

и другие.

Current Opinion in Genetics & Development, Год журнала: 2025, Номер 92, С. 102344 - 102344

Опубликована: Апрель 7, 2025

During the oocyte-to-embryo transition, transcriptome and proteome are dramatically reshaped. This transition entails a shift from maternally inherited mRNAs to newly synthesized transcripts, produced during zygotic genome activation (ZGA). Furthermore, crucial transcription translation selectivity is required for early embryonic development. Studies across various model organisms have revealed conserved cis- trans-regulatory mechanisms dictating regimes by which mRNA proteins this critical phase. In article, we highlight recent technological conceptual advances that deepen our understanding of how tuning both evolves ZGA.

Язык: Английский

Reshaping transcription and translation dynamics during the awakening of the zygotic genome DOI Creative Commons
Louise Maillard, Pierre Bensidoun, Mounia Lagha

и другие.

Current Opinion in Genetics & Development, Год журнала: 2025, Номер 92, С. 102344 - 102344

Опубликована: Апрель 7, 2025

During the oocyte-to-embryo transition, transcriptome and proteome are dramatically reshaped. This transition entails a shift from maternally inherited mRNAs to newly synthesized transcripts, produced during zygotic genome activation (ZGA). Furthermore, crucial transcription translation selectivity is required for early embryonic development. Studies across various model organisms have revealed conserved cis- trans-regulatory mechanisms dictating regimes by which mRNA proteins this critical phase. In article, we highlight recent technological conceptual advances that deepen our understanding of how tuning both evolves ZGA.

Язык: Английский

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