ER tubular body: an ER-derived compartment for redirecting autophagy to secretory functions DOI
Min Seok Song, Hun Ju Sim, Shin Hye Noh

и другие.

Autophagy, Год журнала: 2025, Номер unknown, С. 1 - 3

Опубликована: Май 20, 2025

The secretion of proteins that do not follow the well-characterized endoplasmic reticulum (ER)-Golgi apparatus pathway, known as unconventional protein (UCPS), is gradually revealing its complexities. Our study has identified an ER-based tubulovesicular network, termed ER tubular body (ER-TB), a central compartment in this process. We demonstrate ER-TBs are formed by two reticulophagy receptors, ATL3 and RTN3L, under conditions cellular stress. In addition to their role stress-induced secretion, activation UCPS via facilitates cell surface trafficking trafficking-deficient transmembrane such ΔF508-CFTR. Furthermore, involvement remodeling vesicle suggests potential viral replication, particularly formation membrane compartments utilized positive-strand RNA viruses. By uncovering key structures demonstrating regulation autophagy-related factors, our findings offer valuable insights into homeostasis, pathogenesis, therapeutic strategies for diseases linked defects.

Язык: Английский

ER tubular body: an ER-derived compartment for redirecting autophagy to secretory functions DOI
Min Seok Song, Hun Ju Sim, Shin Hye Noh

и другие.

Autophagy, Год журнала: 2025, Номер unknown, С. 1 - 3

Опубликована: Май 20, 2025

The secretion of proteins that do not follow the well-characterized endoplasmic reticulum (ER)-Golgi apparatus pathway, known as unconventional protein (UCPS), is gradually revealing its complexities. Our study has identified an ER-based tubulovesicular network, termed ER tubular body (ER-TB), a central compartment in this process. We demonstrate ER-TBs are formed by two reticulophagy receptors, ATL3 and RTN3L, under conditions cellular stress. In addition to their role stress-induced secretion, activation UCPS via facilitates cell surface trafficking trafficking-deficient transmembrane such ΔF508-CFTR. Furthermore, involvement remodeling vesicle suggests potential viral replication, particularly formation membrane compartments utilized positive-strand RNA viruses. By uncovering key structures demonstrating regulation autophagy-related factors, our findings offer valuable insights into homeostasis, pathogenesis, therapeutic strategies for diseases linked defects.

Язык: Английский

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