Self-Powered Thermoelectric Hydrogels Accelerate Wound Healing DOI

Yuandong Qin,

Shiyu Jia,

Xiao‐Lei Shi

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Electrical stimulation (ES) serves as a biological cue that regulates critical cellular processes, including proliferation and migration, offering an effective approach to accelerating wound healing. Thermoelectrics, capable of generating electricity by exploiting the temperature difference between skin surrounding environment without external energy input, present promising avenue for ES-based therapies. Herein, we developed Ag2Se@gelatin methacrylate (Ag2Se@GelMA) thermoelectric hydrogels with high room-temperature performance employed them self-powered ES devices repair. Systematic in vivo vitro investigations elucidated their mechanisms enhancing Our findings reveal Ag2Se@GelMA can significantly accelerate closure amplifying endogenous electric field, thereby promoting cell proliferation, angiogenesis. Comprehensive experiments demonstrated generated activates voltage-gated calcium ion channels, elevating intracellular Ca2+ levels mitochondrial functions through Ca2+/CaMKKβ/AMPK/Nrf2 pathway. This cascade improves dynamics angiogenesis, tissue regeneration. The newly represent marked progress dressing technology potential improve clinical strategies engineering regenerative medicine.

Язык: Английский

Achieving ultrahigh power factor in Mg 3(Sb,Bi) 2-based thermoelectric alloys sintered by introducing elemental Mg and W DOI Creative Commons

Liangsheng Wang,

Shunjian Xu, Jian Yang

и другие.

Journal of Advanced Ceramics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Improving the power factor (PF) of thermoelectric materials is crucial for enhancing output density and broadening practical applications. The near-room-temperature electrical performance Mg3(Sb,Bi)2-based alloys hindered due to presence Mg vacancies grain boundary scattering, resulting in lower factor. Herein, we introduced an excess into Mg3(Sb,Bi)2 alloy during hot-pressing process, triggering a liquid phase sintering which can effectively fill increase average size significantly reduce scattering. This leads enhanced room-temperature conductivity (σ) without detrimental effects on Seebeck coefficient (S), thus yielding high PF ~25.3 μW cm-1 K-2 figure merit (ZT) ~ 1.03 within temperature range 323‒623 K. Moreover, different amounts W were further added, density-functional theory (DFT) calculations reveal that segregation at boundaries reduces interfacial potential barriers, leading improved S σ. Consequently, ultrahigh ~26.2 was attained W0.06Mg3.2Sb1.5Bi0.49Te0.01–4%Mg alloys. Additionally, mechanical properties (Vickers hardness fracture toughness) also compared with pristine alloy. dual-modified approach boost TE stability, advancing

Язык: Английский

Процитировано

0

Self-Powered Thermoelectric Hydrogels Accelerate Wound Healing DOI

Yuandong Qin,

Shiyu Jia,

Xiao‐Lei Shi

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Electrical stimulation (ES) serves as a biological cue that regulates critical cellular processes, including proliferation and migration, offering an effective approach to accelerating wound healing. Thermoelectrics, capable of generating electricity by exploiting the temperature difference between skin surrounding environment without external energy input, present promising avenue for ES-based therapies. Herein, we developed Ag2Se@gelatin methacrylate (Ag2Se@GelMA) thermoelectric hydrogels with high room-temperature performance employed them self-powered ES devices repair. Systematic in vivo vitro investigations elucidated their mechanisms enhancing Our findings reveal Ag2Se@GelMA can significantly accelerate closure amplifying endogenous electric field, thereby promoting cell proliferation, angiogenesis. Comprehensive experiments demonstrated generated activates voltage-gated calcium ion channels, elevating intracellular Ca2+ levels mitochondrial functions through Ca2+/CaMKKβ/AMPK/Nrf2 pathway. This cascade improves dynamics angiogenesis, tissue regeneration. The newly represent marked progress dressing technology potential improve clinical strategies engineering regenerative medicine.

Язык: Английский

Процитировано

0