Biomimetic Polythiophene: g-C3N4 Nanotube Composites with Induced Creatinine and Uric Acid Specificity for Portable CKD and Gout Detection DOI

Zohaib Saddique,

Noor Shahzad,

Maleeha Saeed

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Despite significant advancements in disease diagnostics, the development of portable, highly selective, and low-cost electrochemical sensors for real-time, noninvasive detection chronic kidney (CKD) gout biomarkers remains a challenge. In this work, we demonstrate an inexpensive CKD diagnostic platform with incorporation biomimetic polymer matrix nanocomposites based on creatinine (CRE) uric acid (UA) imprinted conducting polythiophene (MIP) graphitic carbon nitride nanotubes (NTs). These are termed CRE-MIPNT or UA-MIPNT, depending template. Disposable devices fabricated by anchoring UA-MIPNT screen-printed Au microelectrodes. The surface micrographs exhibit integration NTs matrix, resulting leptokurtic surfaces. Consequently, charge transfer resistance at electrode-electrolyte interface is significantly reduced, as characterized impedance spectroscopy. An increase electroactive area kinetics also observed CRE-MIPNT/Au-SPE UA-MIPNT/Au-SPE sensors. comparison to nonimprinted sensors, their performance investigated terms voltammetric response toward various biomarker concentrations standard redox solutions. sensitivity CV measurements 0.59 μA cm-2 nM-1 0.78 μM-1 limits 390 pM 162 nM CRE UA, respectively. high selectivity target analytes while showing minimal interference from other metabolites. Moreover, recovery rates spiked saliva samples ranged between 97 102%, which indicates reliability sensor real-world applications.

Язык: Английский

Polycrystalline boron nitride microflowers for non-invasive vitamin B3 (nicotinamide) sensing DOI
Muhammad Farhan, Muhammad Subhan, Shahzad Naseem

и другие.

Diamond and Related Materials, Год журнала: 2025, Номер unknown, С. 112296 - 112296

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Biomimetic Polythiophene: g-C3N4 Nanotube Composites with Induced Creatinine and Uric Acid Specificity for Portable CKD and Gout Detection DOI

Zohaib Saddique,

Noor Shahzad,

Maleeha Saeed

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Despite significant advancements in disease diagnostics, the development of portable, highly selective, and low-cost electrochemical sensors for real-time, noninvasive detection chronic kidney (CKD) gout biomarkers remains a challenge. In this work, we demonstrate an inexpensive CKD diagnostic platform with incorporation biomimetic polymer matrix nanocomposites based on creatinine (CRE) uric acid (UA) imprinted conducting polythiophene (MIP) graphitic carbon nitride nanotubes (NTs). These are termed CRE-MIPNT or UA-MIPNT, depending template. Disposable devices fabricated by anchoring UA-MIPNT screen-printed Au microelectrodes. The surface micrographs exhibit integration NTs matrix, resulting leptokurtic surfaces. Consequently, charge transfer resistance at electrode-electrolyte interface is significantly reduced, as characterized impedance spectroscopy. An increase electroactive area kinetics also observed CRE-MIPNT/Au-SPE UA-MIPNT/Au-SPE sensors. comparison to nonimprinted sensors, their performance investigated terms voltammetric response toward various biomarker concentrations standard redox solutions. sensitivity CV measurements 0.59 μA cm-2 nM-1 0.78 μM-1 limits 390 pM 162 nM CRE UA, respectively. high selectivity target analytes while showing minimal interference from other metabolites. Moreover, recovery rates spiked saliva samples ranged between 97 102%, which indicates reliability sensor real-world applications.

Язык: Английский

Процитировано

0