Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Опубликована: Июль 12, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin's effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2,256 documents, leading selection 15 clinical trials synthesis. Here we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Язык: Английский

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Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Nutrients, Год журнала: 2024, Номер 16(16), С. 2721 - 2721

Опубликована: Авг. 15, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin’s effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2256 documents, leading selection 15 clinical trials synthesis. Here, we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Язык: Английский

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Novel Techniques for Mapping DNA Damage and Repair in the Brain

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7021 - 7021

Опубликована: Июнь 27, 2024

DNA damage in the brain is influenced by endogenous processes and metabolism along with exogenous exposures. Accumulation of can contribute to various neurological disorders, including neurodegenerative diseases neuropsychiatric disorders. Traditional methods for assessing brain, such as immunohistochemistry mass spectrometry, have provided valuable insights but are limited their inability map specific adducts regional distributions within or genome. Recent advancements detection offer new opportunities address these limitations further our understanding repair brain. Here, we review emerging techniques offering more precise sensitive ways detect quantify lesions neural cells. We highlight applications discuss potential determining role disease.

Язык: Английский

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Interdependence between Nuclear Pore Gatekeepers and Genome Caretakers: Cues from Genome Instability Syndromes

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9387 - 9387

Опубликована: Авг. 29, 2024

This review starts off with the first germline homozygous variants of Nucleoporin 98 gene (NUP98) in siblings whose clinical presentation recalls Rothmund–Thomson (RTS) and Werner (WS) syndromes. The progeroid phenotype caused by a associated haematological malignancies neurodegenerative disorders primed search for interplay between caretakers involved genome instability syndromes Nuclear Pore Complex (NPC) components. In context basic information on NPC architecture functions, we discuss studies interdependence gatekeepers WS Hereditary Fibrosing Poikiloderma (POIKTMP), both entering differential diagnosis RTS. WS, WRN/WRNIP complex interacts nucleoporins Y-complex NDC1 altering architecture. POIKTMP, mutated FAM111B, recruited Y-complex’s SEC13 NUP96, several Nups safeguarding structure. linkage defective to highlights attempt activate repair hub at nuclear periphery restore DNA damage. two separate POIKTMP are drawn close interaction their damage sensors shared hallmark short fragile telomeres disclosing major role telomere maintenance.

Язык: Английский

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SimplySmart_v1, a new tool for the analysis of DNA damage optimized in primary neuronal cultures

BMC Bioinformatics, Год журнала: 2024, Номер 25(1)

Опубликована: Окт. 1, 2024

Язык: Английский

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DNAR special issue: DNA damage responses and neurological disease The DNA damage response and neurological disease

DNA repair, Год журнала: 2024, Номер 145, С. 103788 - 103788

Опубликована: Ноя. 14, 2024

Язык: Английский

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