International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(9), С. 3991 - 3991
Опубликована: Апрель 23, 2025
Advances
in
medicinal
chemistry
have
led
to
the
development
of
anticancer
and
anti-infectious
drugs.
However,
many
types
cancer
viral
infections
such
as
hepatitis
B
virus
or
SARS-CoV-2
are
still
treated
ineffectively.
Therefore,
further
effective
selective
lead
compounds
potential
drugs
is
highly
demanded.
In
this
study,
we
synthesized
a
novel
series
piperazine-substituted
pyranopyridines
evaluated
their
antiviral
properties.
Antiproliferative
activity
was
determined
panel
various
tumor
cell
lines
well
non-tumor
hepatic
HepaRG
cells.
Mechanisms
cytotoxicity
were
assessed
by
fluorescent
microscopy
techniques.
Antiviral
analyzed
towards
DNA
RNA
viruses
infectious
culture
systems.
Several
showed
antiproliferative
at
micromolar
submicromolar
concentrations.
involve
induction
apoptosis
not
mediated
via
ERK1/2
pathway
oxidative
stress.
exhibit
against
preventing
formation
virion
particles.
This
study
identification
class
with
wide
range
non-toxic
inhibitor
HBV
production.
Toxins,
Год журнала:
2025,
Номер
17(2), С. 56 - 56
Опубликована: Янв. 24, 2025
Bacillus
anthracis
is
a
deadly
pathogen
that
under
unfavourable
conditions
forms
highly
resistant
spores
which
enable
them
to
survive
for
long
period
of
time.
Spores
B.
are
transmitted
through
the
contaminated
soil
or
animal
products
and
enter
host
skin,
lungs
oral
route
can
cause
cutaneous,
injection,
inhalation
gastrointestinal
anthrax,
respectively.
The
disease
caused
by
toxin
produced
once
they
germinate
within
cell.
Anthrax
major
virulence
factor
has
ability
kill
role
protein
kinases
phosphatases
in
production
other
related
properties
have
also
been
reported.
There
two
vaccines,
BioThrax
CYFENDUSTM,
approved
FDA-USA
prevent
anthrax
disease.
Recently,
shown
be
potential
candidate
cancer
therapeutics.
Through
present
review,
we
aim
provide
insights
into
sporulation,
transmission
pathogenesis
as
well
current
state
its
prevention,
treatment,
vaccines
possible
therapeutic
uses
cancer.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 12, 2025
Abstract
Lipid-based
drug
delivery
systems
are
very
promising
in
addressing
critical
medical
needs
associated
with
cancer
because
they
able
to
enhance
the
efficacy
of
therapeutic
agents
loaded
in.
Yet,
their
transferability
from
bench
bedside
is
still
a
challenge
as
it
hits
many
barriers.
Among
them,
absence
clear
design
made
on
deeper
understanding
intermolecular
forces
underlying
formation
drug-carrier
system
and
controlled
release
relevant.
In
this
contribution,
we
rationally
designed
prepared
lipid-based
formulations
an
anticancer
drug,
fluorouracil
(FU
-
hydrophilic)
anti-inflammatory
ibuprofen
(IBU
hydrophobic)
thoroughly
characterize
specific
interactions
between
drugs
components
carrier
matrix.
Microemulsions
(ME)
were
selected
main
carriers
for
study,
but
comparison
liposomes
was
performed
observe
if
different
organization
lipophilic
hydrophilic
compartments
influences
loading
capacity
these
two
drugs.
Using
Maisine
CC,
biocompatible
oil,
Tween
20
surfactant,
normal
oil-in-water
ME
FU
IBU
(1:1,
1:3,
1:6,
wt:wt)
by
water
titration
method.
MEs
characterized
DLS,
Zeta
potential,
DOSY
spectroscopies
assess
droplet
size,
surface
charge,
structure
type
emulsion.
Intermolecular
ME’s
matrix
investigated
FT-IR,
RAMAN
1
H-NMR
spectroscopies.
The
experimental
results
revealed
that
all
gathered
ME.
Due
affinities
ME,
FU,
mainly
distributed
aqueous
oily
phases,
respectively,
supported
size
measured
DLS.
It
observed
co-loading
impacted
behavior,
assessed
dialysis
bag
method,
compared
mono-drug
formulations.
Based
findings
work,
mechanism
proposed,
well.
Overall,
proved
be
more
suitable
nanocarriers
since
drugs,
which
higher
amounts
liposomes,
followed
sustained
at
least
96
h.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Март 21, 2025
The
early
diagnosis
rate
of
gastric
cancer
is
low,
and
most
patients
are
already
at
an
advanced
stage
by
the
time
they
diagnosed,
posing
significant
challenges
for
treatment
exhibiting
high
recurrence
rates,
which
notably
diminish
patients’
survival
quality
life.
Therefore,
there
urgent
need
to
identify
methods
that
can
enhance
efficacy.
Nanomedicine,
distinguished
its
small
size,
targeting
specificity,
strong
biological
compatibility,
particularly
well-suited
address
toxic
side
effects
associated
with
current
diagnostic
therapeutic
approaches
cancer.
Consequently,
application
nanomedicine
delivery
systems
in
has
garnered
increasing
interest
from
researchers.
This
review
provides
overview
recent
advancements
use
nanomaterials
as
drugs
or
drug
research,
encompassing
their
applications
diagnosis,
chemotherapy,
radiotherapy,
surgery,
phototherapy,
explores
promising
prospects
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(9), С. 3991 - 3991
Опубликована: Апрель 23, 2025
Advances
in
medicinal
chemistry
have
led
to
the
development
of
anticancer
and
anti-infectious
drugs.
However,
many
types
cancer
viral
infections
such
as
hepatitis
B
virus
or
SARS-CoV-2
are
still
treated
ineffectively.
Therefore,
further
effective
selective
lead
compounds
potential
drugs
is
highly
demanded.
In
this
study,
we
synthesized
a
novel
series
piperazine-substituted
pyranopyridines
evaluated
their
antiviral
properties.
Antiproliferative
activity
was
determined
panel
various
tumor
cell
lines
well
non-tumor
hepatic
HepaRG
cells.
Mechanisms
cytotoxicity
were
assessed
by
fluorescent
microscopy
techniques.
Antiviral
analyzed
towards
DNA
RNA
viruses
infectious
culture
systems.
Several
showed
antiproliferative
at
micromolar
submicromolar
concentrations.
involve
induction
apoptosis
not
mediated
via
ERK1/2
pathway
oxidative
stress.
exhibit
against
preventing
formation
virion
particles.
This
study
identification
class
with
wide
range
non-toxic
inhibitor
HBV
production.
