Biopolymeric Inhalable Dry Powders for Pulmonary Drug Delivery

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1628 - 1628

Опубликована: Дек. 4, 2024

Natural and synthetic biopolymers are gaining popularity in the development of inhaled drug formulations. Their highly tunable properties ability to sustain release allow for incorporation attributes not achieved dry powder inhaler formulations composed only micronized drugs, standard excipients, and/or carriers. There multiple physiological barriers penetration drugs epithelial surface, such as periciliary layer mucus mesh, pulmonary macrophages, inflammation compositional changes resulting from respiratory diseases. Biopolymers may facilitate transport surface despite barriers. A variety categories have been assessed their potential throughout research literature, ranging natural (e.g., chitosan, alginate, hyaluronic acid) those synthesized a laboratory setting polycaprolactone, poly(lactic-co-glycolic acid)) with varying structures compositions. To date, no approved commercial product. However, advances be possible treatment diseases infections upon further investigation evaluation. Herein, this review will provide thorough foundation reported utilizing Furthermore, insight considerations future proposed.

Язык: Английский

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Biodegradable Long-Acting Injectables: Platform Technology and Industrial Challenges

Handbook of experimental pharmacology, Год журнала: 2023, Номер unknown, С. 133 - 150

Опубликована: Янв. 1, 2023

Язык: Английский

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Injectable long-acting formulations (ILAFs) and manufacturing techniques

Expert Opinion on Drug Delivery, Год журнала: 2024, Номер 21(6), С. 881 - 904

Опубликована: Июнь 2, 2024

Most therapeutics delivered using short-acting formulations need repeated administration, which can harm patient compliance and raise failure risks related to inconsistent treatment. Injectable long-acting (ILAFs) are controlled/sustained-release fabricated deliver active pharmaceutical ingredients (APIs) extend their half-life over days months. Longer half-lives of ILAFs minimize the necessity for frequent doses, increase compliance, reduce risk side effects from intravenous (IV) infusions. Using ILAF technologies, immediate drug release also be controlled, thereby minimizing potential adverse due high initial blood concentrations.

Язык: Английский

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Multiscale modelling of biopolymers

Advances in Physics X, Год журнала: 2024, Номер 9(1)

Опубликована: Июль 3, 2024

This review overviews common biopolymer modelling approaches ranging from chemically specific to highly coarse-grained techniques, along with their application ranges, strengths and limitations. Recent applications at each scale are outlined discussed. The focus is on of protein peptide, nucleic acid saccharide-based systems, excluding lignocellulose materials. survey focuses physics-based models. We cover particle-based simulations methods, including all-atom molecular dynamics (MD), dissipative particle (DPD) Langevin Brownian (BD) approaches. While these methods capture particle-level dynamics, a brief overview also stochastic sampling (Monte Carlo methods) models, as well free energy functional-based i.e. field theory approaches, such self-consistent (SCFT) classical density functional (cDFT), provided.

Язык: Английский

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Ketorolac Loaded Poly(lactic-co-glycolic acid) Coating of AZ31 in the Treatment of Bone Fracture Pain

Polymers, Год журнала: 2023, Номер 15(10), С. 2246 - 2246

Опубликована: Май 9, 2023

Biodegradable metal alloys may be successfully used to support bone repair, avoiding second surgery commonly needed when inert are used. Combining a biodegradable alloy with suitable pain relief agent could improve patient quality of life. AZ31 was coated using poly(lactic-co-glycolic) acid (PLGA) polymer loaded ketorolac tromethamine the solvent casting method. The release profile from polymeric film and samples, PLGA mass loss film, cytotoxicity optimized were assessed. sample showed that prolonged for two weeks, which slower than just in simulated body fluid. complete after 45-day immersion coating able lower observed human osteoblasts. also prevents cytotoxicity, identified fibroblasts. Therefore, control protect premature corrosion. These characteristics allow us hypothesize use tromethamine-loaded on management fractures can favor osteosynthesis pain.

Язык: Английский

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Surface modified cationic PLGA microparticles as long-acting injectable carriers for intra-articular small molecule drug delivery

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2023, Номер 193, С. 96 - 104

Опубликована: Окт. 29, 2023

Язык: Английский

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Pharmaceutical and biomedical polymers: Basics, modifications, and applications

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 1 - 86

Опубликована: Янв. 1, 2024

Язык: Английский

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Exploring Piperine: Unleashing the multifaceted potential of a phytochemical in cancer therapy

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Окт. 12, 2024

Язык: Английский

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