Modified SPPS Protocol for the Synthesis of Novel Antimicrobial Peptides

International Journal of Peptide Research and Therapeutics, Год журнала: 2025, Номер 31(4)

Опубликована: Апрель 21, 2025

Язык: Английский

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Anti-virulence and anti-efflux pump activity of synthetic defensins and histatin in Candida auris

Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107644 - 107644

Опубликована: Апрель 1, 2025

Язык: Английский

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Recent Advances and Future Prospects in Biological-Membrane-Targeted Polymers

Polymer science & technology., Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

Язык: Английский

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Effects of oral delivery of two antimicrobial peptides CATHPb1 and As-CATH4 by bait microalga [Tetraselmis subcordiformis (Wille) Butcher] on resistance to bacterial infection in turbot (Scophthalmus maximus L.)

Aquaculture Reports, Год журнала: 2025, Номер 42, С. 102803 - 102803

Опубликована: Май 1, 2025

Язык: Английский

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Antimicrobial Peptides: An Emerging Hope in the Era of New Infections and Resistance

Antibiotics, Год журнала: 2025, Номер 14(6), С. 546 - 546

Опубликована: Май 27, 2025

Recently, antimicrobial peptides (AMPs) have garnered significant attention as a viable alternative to traditional antibiotics [...]

Язык: Английский

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Rational design of hybrid peptide with high antimicrobial property derived from Melittin and Lasioglossin

Journal of Biomolecular Structure and Dynamics, Год журнала: 2023, Номер 42(23), С. 13091 - 13099

Опубликована: Окт. 26, 2023

Hybridization of Antimicrobial peptides (AMPs) with unique abilities is now considered to improve AMPs' function as promising therapeutic candidates. In the current research, Lasioglossin (LL-III) a high antimicrobial effect on Acinetobacter (A.) baumanni and Melittin against Staphylococcus (S.) aureus were selected for designing hybrid peptide modified properties. present study, properties was designed. Molecular dynamic (MD) coarse-grained (CG) simulations done evaluate stability interaction related membrane models. this truncated (11 amino acids) fused an LL-III (15 raise activity. A new analog (LM1) by replacing arginine isoleucine in fifth position rate peptide. The potential binding LM1 lipid (D factor) increased from 2.02 3.62. Based VMD results, N-terminal alpha helix during 200 ns. However, C-terminal region only at 50 ns form. RMSD range 0.2 0.8, which, after 160 ns, reached stability. RMSF results indicated no unwanted fluctuations MD simulation. significant movement inside S. membrane(4.76 nm) A. (3.2 observed CG Our findings highlight designed its halter baumanii bacteria.

Язык: Английский

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CATH-2-derived antimicrobial peptide inhibits multidrug-resistant Escherichia coli infection in chickens

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Май 15, 2024

Avian colibacillosis (AC), caused by infection with Escherichia coli ( E. ), is a major threat to poultry health, food safety and public results in high mortality significant economic losses. Currently, new drugs are urgently needed replace antibiotics due the continuous emergence increasing resistance of multidrug-resistant (MDR) strains irrational use agriculture animal husbandry. In recent years, antimicrobial peptides (AMPs), which uniquely evolved protect host, have emerged as leading alternative clinical settings. CATH-2, member cathelicidin peptide family, has been reported antibacterial activity. To enhance potency reduce adverse effects on animals, we designed five novel AMPs, named C2-1, C2-2, C2-3, C2-4 C2-5, based chicken secondary structures these AMPs were consistently α-helical had an altered net charge hydrophobicity compared those CATH-2 (1-15) sequences. Subsequently, activities against MDR evaluated vitro . Specifically, C2-2 showed excellent activity either ATCC standard strain or veterinary isolates , concentrations ranging from 2-8 μ g/mL. Furthermore, maintained its strong efficacy under temperature saline conditions, demonstrating stability. Similarly, retained level no hemolytic mature red blood cells cytotoxicity kidney over concentration range 0-64 Moreover, administration improved survival rate reduced bacterial load heart, liver spleen during chickens. Additionally, pathological damage intestine was prevented when infected chickens treated C2-2. Together, our study that may be promising therapeutic agent for treatment infections AC.

Язык: Английский

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Screening of Short-Chain Peptide RKIIIRW and Its Use as a Hydrogel for Wound Healing and Bacterial Infection Treatment

ACS Applied Polymer Materials, Год журнала: 2024, Номер 6(17), С. 10452 - 10466

Опубликована: Авг. 15, 2024

Microbial resistance has gradually emerged as a significant challenge in global health care, mainly due to the overuse of antimicrobials. In face this challenge, antimicrobial peptides (AMPs) have potential therapeutic agent their excellent activity. work, Gram-negative bacteria (E. coli) and Gram-positive (S. aureus) were selected bacterial models. The membrane chromatographic stationary phase was prepared by extracting membranes E. coli S. aureus fixing them on silica microspheres. According principle electrostatic adsorption AMPs kill bacteria, we designed developed series short-chain AMPs. Then, investigated cationic AMP RKIIIRW, which effectively killed aureus, using cell chromatography combined with high-performance liquid chromatography. We kind antibacterial peptide hydrogel sodium alginate/hyaluronic acid treat infections promote wound healing. inhibits infection damaged skin slowly releasing RKIIIRW while promoting growth tissue cells accelerating summary, successfully screened treatment system that can inhibit

Язык: Английский

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Antimicrobial Peptide Delivery Systems as Promising Tools Against Resistant Bacterial Infections

Antibiotics, Год журнала: 2024, Номер 13(11), С. 1042 - 1042

Опубликована: Ноя. 4, 2024

The extensive use of antibiotics during recent years has led to antimicrobial resistance development, a significant threat global public health. It is estimated that around 1.27 million people died worldwide in 2019 due infectious diseases caused by antibiotic-resistant microorganisms, according the WHO. 700,000 die each year worldwide, which expected rise 10 2050. Therefore, new and efficient antimicrobials against resistant pathogenic bacteria are urgently needed. Antimicrobial peptides (AMPs) present broad spectrum antibacterial effects considered potential tools for developing novel therapies combat infections. However, their clinical application currently limited instability, low selectivity, toxicity, bioavailability, resulting narrow therapeutic window. Here we describe an overview AMPs bacterial infections through nanoformulation. evaluates metal, polymeric, lipid AMP delivery systems as promising treatment infections, offering solution aforementioned limitations.

Язык: Английский

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A Robust Strategy Against Multi-Resistant Pathogens in Oral Health: Harnessing the Potency of Antimicrobial Peptides in Nanofiber-Mediated Therapies

International Journal of Peptide Research and Therapeutics, Год журнала: 2024, Номер 30(3)

Опубликована: Май 3, 2024

Язык: Английский

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