Veterinary Microbiology, Год журнала: 2024, Номер 298, С. 110267 - 110267
Опубликована: Сен. 27, 2024
Язык: Английский
Veterinary Microbiology, Год журнала: 2024, Номер 298, С. 110267 - 110267
Опубликована: Сен. 27, 2024
Язык: Английский
Computers in Biology and Medicine, Год журнала: 2024, Номер 182, С. 109157 - 109157
Опубликована: Сен. 24, 2024
Язык: Английский
Процитировано
1Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 247, С. 114451 - 114451
Опубликована: Дек. 11, 2024
Язык: Английский
Процитировано
1Process Biochemistry, Год журнала: 2024, Номер 146, С. 1 - 12
Опубликована: Июль 3, 2024
Язык: Английский
Процитировано
0Pathogens, Год журнала: 2024, Номер 13(9), С. 797 - 797
Опубликована: Сен. 14, 2024
The accelerating spread of antibiotic resistance has significantly weakened the clinical efficacy existing antibiotics, posing a severe threat to public health. There is an urgent need develop novel antimicrobial alternatives that can bypass mechanisms and effectively kill multidrug-resistant (MDR) pathogens. Antimicrobial peptides (AMPs) are one most promising candidates treat MDR pathogenic infections since they display broad-spectrum activities less prone achieve drug resistance. In this study, we investigated antibacterial capability two machine learning-driven linear peptide compounds termed YI12 FK13. We reveal FK13 exhibit properties against clinically significant bacterial pathogens, inducing no or minimal hemolysis in mammalian red blood cells. further ascertain resilient heat acid-base conditions, susceptibility hydrolytic enzymes divalent cations under physiological conditions. Initial mechanistic investigations compromise membrane integrity, leading potential dissipation excessive reactive oxygen species (ROS) generation. Collectively, our findings highlight prospective utility these cationic amphiphilic as agents.
Язык: Английский
Процитировано
0Veterinary Microbiology, Год журнала: 2024, Номер 298, С. 110267 - 110267
Опубликована: Сен. 27, 2024
Язык: Английский
Процитировано
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