Molecular and Cellular Biochemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 23, 2024
Abstract
The
global
burden
of
cancer
as
a
major
cause
death
and
invalidity
has
been
constantly
increasing
in
the
past
decades.
Monoamine
oxidases
(MAO)
with
two
isoforms,
MAO-A
MAO-B,
are
mammalian
mitochondrial
enzymes
responsible
for
oxidative
deamination
neurotransmitters
amines
central
nervous
system
peripheral
tissues
constant
generation
hydrogen
peroxide
main
deleterious
ancillary
product.
However,
given
complexity
biology,
MAO
involvement
tumorigenesis
is
multifaceted
different
tumors
displaying
either
an
increased
or
decreased
profile.
inhibitors
currently
approved
treatment
neurodegenerative
diseases
(mainly,
Parkinson’s
disease)
secondary/adjunctive
therapeutic
options
depression.
Herein,
we
review
literature
characterizing
MAO’s
putative
role
several
malignancies,
also
provide
perspectives
regarding
potential
biomarker
that
could
play
future
oncology.
Pharmacological Reviews,
Год журнала:
2023,
Номер
76(2), С. 300 - 320
Опубликована: Дек. 7, 2023
In
humans,
there
are
two
arylamine
N-acetyltransferase
genes
that
encode
functional
enzymes
(NAT1
and
NAT2)
as
well
one
pseudogene,
all
of
which
located
together
on
chromosome
8.
While
they
were
first
identified
by
their
role
in
the
acetylation
drugs
other
xenobiotics,
recent
studies
have
shown
strong
associations
for
both
a
variety
diseases
including
cancer,
cardiovascular
disease,
diabetes.
There
is
growing
evidence
this
association
may
be
causal.
Consistently,
NAT1
NAT2
to
required
healthy
mitochondrial.
This
review
discusses
current
literature
mitochondrial
bioenergetics.
It
will
attempt
relate
our
understanding
evolution
with
biological
function
then
present
several
major
metabolic
influenced
NAT2.
Finally,
it
discuss
future
approaches
inhibit
or
enhance
activity/expression
using
small
molecule
drugs.
Significance
Statement
The
N-acetyltransferases,
NAT2,
share
common
features
Together,
potential
drug
targets
where
dysfunction
hallmark
onset
progression.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 21, 2024
Group
2
Innate
Lymphoid
Cells
(ILC2)
are
critical
drivers
of
both
innate
and
adaptive
type
immune
responses,
known
to
orchestrate
processes
involved
in
tissue
restoration
wound
healing.
In
addition,
ILC2
have
been
implicated
chronic
inflammatory
barrier
disorders
immunopathologies
such
as
allergic
rhinitis
asthma.
the
context
allergen-driven
airway
inflammation
recently
shown
influence
local
systemic
metabolism,
well
being
rich
lipid-storing
organelles
called
lipid
droplets.
However,
mechanisms
anabolism
catabolism
remain
largely
unknown
impact
these
metabolic
regulating
phenotypes
effector
functions
has
not
extensively
characterized.
shaped
by
their
status,
determining
requirements
is
understanding
role
responses
associated
pathophysiology.
We
detail
here
a
novel
experimental
method
implementing
flow
cytometry
for
large
scale
analysis
fatty
acid
uptake,
storage
neutral
lipids,
oxidation
primary
murine
with
complementary
morphological
using
confocal
microscopy.
By
combining
microscopy,
we
can
identify
characterize
phenotype
ILC2.
Linking
metabolism
pathways
assessment
pharmaceutical
strategies
regulate
immunopathologies.
Cancers,
Год журнала:
2024,
Номер
16(24), С. 4253 - 4253
Опубликована: Дек. 20, 2024
Despite
significant
progress
in
the
field
of
clinical
oncology
terms
diagnostic
and
treatment
methods,
results
anticancer
therapy
are
still
not
fully
satisfactory,
especially
due
to
limited
response
high
toxicity.
This
has
forced
need
for
further
research
finding
alternative
ways
improve
success
rates
oncological
treatment.
A
good
solution
this
problem
context
rapidly
obtaining
an
effective
drug
that
works
on
multiple
levels
cancer
is
also
safe
global
strategy
repurposing
existing
drug.
Research
into
other
applications
enables
a
precise
assessment
its
possible
mechanisms
action
and,
consequently,
broadening
therapeutic
indications.
supported
by
fact
most
non-oncological
drugs
have
pleiotropic
effects,
diseases
which
they
were
originally
intended
multifactorial,
turn
very
desirable
phenomenon
heterogeneous
multifaceted
biology
cancer.
In
review,
we
will
mainly
focus
potential
H1
antihistamines,
new
generation
therapy,
highlight
relevant
signaling
pathways
discuss
properties
these
agents
their
judicious
use
based
characteristic
features
Current Medicinal Chemistry,
Год журнала:
2024,
Номер
31(30), С. 4867 - 4879
Опубликована: Март 29, 2024
Background:
Colorectal
cancer
(CC)
is
the
fourth
most
common
type
of
that
causes
illness
and
death.
Medicines
like
ACE
inhibitors
ARBs,
usually
used
for
heart
problems,
have
shown
they
might
help
with
growth
development
CC.
Introduction:
An
analysis
colon
conducted
in
this
comprehensive
review.
The
main
goal
to
see
how
ACEIs/ARBs
affect
chances
getting
dying
patients
Methods:
A
systematic
literature
search
was
identify
relevant
studies.
Inclusion
criteria
encompassed
studies
evaluated
use
CC
reported
outcomes
related
new
incidence
mortality.
Data
from
selected
were
extracted
analyzed
using
appropriate
statistical
methods.
Results:
study
showed
fewer
cases
occurred
who
took
compared
those
did
not
(RR
0.962,
95%
CI
0.934-0.991,
p
=
0.010).
Furthermore,
utilized
exhibited
a
decreased
mortality
rate
non-users
(HR
0.833,
0.640-1.085,
0.175).
Conclusion:
This
review
suggests
medicine
could
people
live
longer
lower
their
dying.
These
results
highlight
potential
benefits
utilizing
management
CC,
warranting
further
investigation
consideration
clinical
practice.
Journal of Proteome Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
Metabolic
rewiring
is
required
for
cancer
cells
to
survive
in
harsh
microenvironments
and
considered
be
a
hallmark
of
cancer.
Specific
metabolic
adaptations
are
tumor
become
invasive
metastatic.
Cell
division
metabolism
inherently
interconnected,
several
cell
cycle
modulators
directly
regulate
metabolism.
Here,
we
report
that
TBK1,
which
noncanonical
IKK
kinase
with
known
roles
regulation
TLR
signaling,
affects
cellular
cells.
While
TBK1
reported
overexpressed
cancers
its
enhanced
protein
level
correlates
poor
prognosis,
the
underlying
molecular
mechanism
involved
tumor-promoting
role
not
fully
understood.
In
this
study,
show
novel
regulating
using
combined
metabolomics,
transcriptomics,
pharmacological
approaches.
We
find
mediates
nucleotide
energy
through
aldo-keto
reductase
B10
(AKRB10)
thymidine
phosphorylase
(TYMP)
genes,
suggesting
TBK1-mediated
contributes
oncogenic
function.
addition,
inhibitors
can
act
synergistically
AKRB10
TYMP
reduce
viability.
These
findings
raise
possibility
combining
these
might
beneficial
combating
elevated
levels
TBK1.
Molecular and Cellular Biochemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 23, 2024
Abstract
The
global
burden
of
cancer
as
a
major
cause
death
and
invalidity
has
been
constantly
increasing
in
the
past
decades.
Monoamine
oxidases
(MAO)
with
two
isoforms,
MAO-A
MAO-B,
are
mammalian
mitochondrial
enzymes
responsible
for
oxidative
deamination
neurotransmitters
amines
central
nervous
system
peripheral
tissues
constant
generation
hydrogen
peroxide
main
deleterious
ancillary
product.
However,
given
complexity
biology,
MAO
involvement
tumorigenesis
is
multifaceted
different
tumors
displaying
either
an
increased
or
decreased
profile.
inhibitors
currently
approved
treatment
neurodegenerative
diseases
(mainly,
Parkinson’s
disease)
secondary/adjunctive
therapeutic
options
depression.
Herein,
we
review
literature
characterizing
MAO’s
putative
role
several
malignancies,
also
provide
perspectives
regarding
potential
biomarker
that
could
play
future
oncology.
