The highs and lows of monoamine oxidase as molecular target in cancer: an updated review DOI Creative Commons
Iasmina M. Hâncu,

Silvia Giuchici,

Adina V. Furdui-Lința

и другие.

Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Abstract The global burden of cancer as a major cause death and invalidity has been constantly increasing in the past decades. Monoamine oxidases (MAO) with two isoforms, MAO-A MAO-B, are mammalian mitochondrial enzymes responsible for oxidative deamination neurotransmitters amines central nervous system peripheral tissues constant generation hydrogen peroxide main deleterious ancillary product. However, given complexity biology, MAO involvement tumorigenesis is multifaceted different tumors displaying either an increased or decreased profile. inhibitors currently approved treatment neurodegenerative diseases (mainly, Parkinson’s disease) secondary/adjunctive therapeutic options depression. Herein, we review literature characterizing MAO’s putative role several malignancies, also provide perspectives regarding potential biomarker that could play future oncology.

Язык: Английский

The Arylamine N-Acetyltransferases as Therapeutic Targets in Metabolic Diseases Associated with Mitochondrial Dysfunction DOI Open Access
Chandra Choudhury,

Melinder K. Gill,

Courtney E. McAleese

и другие.

Pharmacological Reviews, Год журнала: 2023, Номер 76(2), С. 300 - 320

Опубликована: Дек. 7, 2023

In humans, there are two arylamine N-acetyltransferase genes that encode functional enzymes (NAT1 and NAT2) as well one pseudogene, all of which located together on chromosome 8. While they were first identified by their role in the acetylation drugs other xenobiotics, recent studies have shown strong associations for both a variety diseases including cancer, cardiovascular disease, diabetes. There is growing evidence this association may be causal. Consistently, NAT1 NAT2 to required healthy mitochondrial. This review discusses current literature mitochondrial bioenergetics. It will attempt relate our understanding evolution with biological function then present several major metabolic influenced NAT2. Finally, it discuss future approaches inhibit or enhance activity/expression using small molecule drugs. Significance Statement The N-acetyltransferases, NAT2, share common features Together, potential drug targets where dysfunction hallmark onset progression.

Язык: Английский

Процитировано

5

Analysis of lipid uptake, storage, and fatty acid oxidation by group 2 innate lymphoid cells DOI Creative Commons

Audrey Roy-Dorval,

Rebecca C. Deagle,

F. X. Roth

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Окт. 21, 2024

Group 2 Innate Lymphoid Cells (ILC2) are critical drivers of both innate and adaptive type immune responses, known to orchestrate processes involved in tissue restoration wound healing. In addition, ILC2 have been implicated chronic inflammatory barrier disorders immunopathologies such as allergic rhinitis asthma. the context allergen-driven airway inflammation recently shown influence local systemic metabolism, well being rich lipid-storing organelles called lipid droplets. However, mechanisms anabolism catabolism remain largely unknown impact these metabolic regulating phenotypes effector functions has not extensively characterized. shaped by their status, determining requirements is understanding role responses associated pathophysiology. We detail here a novel experimental method implementing flow cytometry for large scale analysis fatty acid uptake, storage neutral lipids, oxidation primary murine with complementary morphological using confocal microscopy. By combining microscopy, we can identify characterize phenotype ILC2. Linking metabolism pathways assessment pharmaceutical strategies regulate immunopathologies.

Язык: Английский

Процитировано

1

Citation: Trybus, E.; Trybus, W. H1 Antihistamines—Promising Candidates for Repurposing in the Context of the Development of New Therapeutic Approaches to Cancer Treatment. Cancers 2024, 16, 4253. https://doi.org/10.3390/cancers16244253 DOI Open Access
Ewa Trybus, Wojciech Trybus

Cancers, Год журнала: 2024, Номер 16(24), С. 4253 - 4253

Опубликована: Дек. 20, 2024

Despite significant progress in the field of clinical oncology terms diagnostic and treatment methods, results anticancer therapy are still not fully satisfactory, especially due to limited response high toxicity. This has forced need for further research finding alternative ways improve success rates oncological treatment. A good solution this problem context rapidly obtaining an effective drug that works on multiple levels cancer is also safe global strategy repurposing existing drug. Research into other applications enables a precise assessment its possible mechanisms action and, consequently, broadening therapeutic indications. supported by fact most non-oncological drugs have pleiotropic effects, diseases which they were originally intended multifactorial, turn very desirable phenomenon heterogeneous multifaceted biology cancer. In review, we will mainly focus potential H1 antihistamines, new generation therapy, highlight relevant signaling pathways discuss properties these agents their judicious use based characteristic features

Язык: Английский

Процитировано

1

Anticancer Potential of ACEIs/ARBs Administration in Colorectal Cancer DOI
Xin Wang,

Haiyun Jing

Current Medicinal Chemistry, Год журнала: 2024, Номер 31(30), С. 4867 - 4879

Опубликована: Март 29, 2024

Background: Colorectal cancer (CC) is the fourth most common type of that causes illness and death. Medicines like ACE inhibitors ARBs, usually used for heart problems, have shown they might help with growth development CC. Introduction: An analysis colon conducted in this comprehensive review. The main goal to see how ACEIs/ARBs affect chances getting dying patients Methods: A systematic literature search was identify relevant studies. Inclusion criteria encompassed studies evaluated use CC reported outcomes related new incidence mortality. Data from selected were extracted analyzed using appropriate statistical methods. Results: study showed fewer cases occurred who took compared those did not (RR 0.962, 95% CI 0.934-0.991, p = 0.010). Furthermore, utilized exhibited a decreased mortality rate non-users (HR 0.833, 0.640-1.085, 0.175). Conclusion: This review suggests medicine could people live longer lower their dying. These results highlight potential benefits utilizing management CC, warranting further investigation consideration clinical practice.

Язык: Английский

Процитировано

0

Drug repurposing for metabolic disorders: Scientific, technological and economic issues DOI

Nhat-Le Bui,

Duc-Anh Hoang,

Quang-Anh Ho

и другие.

Progress in molecular biology and translational science, Год журнала: 2024, Номер unknown, С. 321 - 336

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0

The potential protective effects and mechanisms of fasting on neurodegenerative disorders: A narrative review DOI

Sahar Golpour-Hamedani,

Gholamreza Askari, Fariborz Khorvash

и другие.

Brain Research, Год журнала: 2024, Номер unknown, С. 149348 - 149348

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

0

TBK1 Reprograms Metabolism in Breast Cancer: An Integrated Omics Approach DOI
Meenu Maan, Neha Jaiswal, Min Liu

и другие.

Journal of Proteome Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Metabolic rewiring is required for cancer cells to survive in harsh microenvironments and considered be a hallmark of cancer. Specific metabolic adaptations are tumor become invasive metastatic. Cell division metabolism inherently interconnected, several cell cycle modulators directly regulate metabolism. Here, we report that TBK1, which noncanonical IKK kinase with known roles regulation TLR signaling, affects cellular cells. While TBK1 reported overexpressed cancers its enhanced protein level correlates poor prognosis, the underlying molecular mechanism involved tumor-promoting role not fully understood. In this study, show novel regulating using combined metabolomics, transcriptomics, pharmacological approaches. We find mediates nucleotide energy through aldo-keto reductase B10 (AKRB10) thymidine phosphorylase (TYMP) genes, suggesting TBK1-mediated contributes oncogenic function. addition, inhibitors can act synergistically AKRB10 TYMP reduce viability. These findings raise possibility combining these might beneficial combating elevated levels TBK1.

Язык: Английский

Процитировано

0

The highs and lows of monoamine oxidase as molecular target in cancer: an updated review DOI Creative Commons
Iasmina M. Hâncu,

Silvia Giuchici,

Adina V. Furdui-Lința

и другие.

Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Abstract The global burden of cancer as a major cause death and invalidity has been constantly increasing in the past decades. Monoamine oxidases (MAO) with two isoforms, MAO-A MAO-B, are mammalian mitochondrial enzymes responsible for oxidative deamination neurotransmitters amines central nervous system peripheral tissues constant generation hydrogen peroxide main deleterious ancillary product. However, given complexity biology, MAO involvement tumorigenesis is multifaceted different tumors displaying either an increased or decreased profile. inhibitors currently approved treatment neurodegenerative diseases (mainly, Parkinson’s disease) secondary/adjunctive therapeutic options depression. Herein, we review literature characterizing MAO’s putative role several malignancies, also provide perspectives regarding potential biomarker that could play future oncology.

Язык: Английский

Процитировано

0