ACS Applied Polymer Materials,
Год журнала:
2024,
Номер
6(16), С. 9545 - 9558
Опубликована: Авг. 14, 2024
In
the
preservation
of
water-rich
foods,
especially
meat,
spoilage
can
occur
due
to
bacterial
contamination
and
oxidative
degradation.
This
study
aimed
determine
structural
characteristics
synthesis
chitosan-graft-pomegranate
extract
(CS-g-POM)
hydrogel
using
a
cost-effective
biobased
method
develop
antibacterial
antioxidant
pads.
Pomegranate
is
used
fabricate
covalently
noncovalently
interconnected
chitosan
networks.
Several
characterization
methods,
such
as
Fourier
transform
infrared
spectroscopy,
thermogravimetric
analysis,
field
emission
scanning
electron
microscopy,
atomic
force
rheological
confirmed
successful
design
produced
hydrogel.
The
freeze-dried
CS-g-POM
had
swelling
ratio
373%,
614%,
508.5%
at
pH
5,
7.4,
10,
respectively.
FE-SEM
images
showed
porous
hydrogel,
which
cross-linking
process.
addition
pomegranate
increased
phenolic
content,
resulting
in
DPPH
radical
scavenging
activity
50.20%.
also
good
properties,
with
inhibition
zones
against
Escherichia
coli
Staphylococcus
aureus
measuring
18
±
1
mm
12
mm.
plays
crucial
role
moisture
absorption
foods
meat
its
high
degree
could
be
an
pad.
Gels,
Год журнала:
2024,
Номер
10(5), С. 295 - 295
Опубликована: Апрель 25, 2024
Biomedicine
is
constantly
evolving
to
ensure
a
significant
and
positive
impact
on
healthcare,
which
has
resulted
in
innovative
distinct
requisites
such
as
hydrogels.
Chitosan-based
formulations
stand
out
for
their
versatile
utilization
drug
encapsulation,
transport,
controlled
release,
complemented
by
biocompatibility,
biodegradability,
non-immunogenic
nature.
Stimuli-responsive
hydrogels,
also
known
smart
have
strictly
regulated
release
patterns
since
they
respond
adapt
based
various
external
stimuli.
Moreover,
can
imitate
the
intrinsic
tissues’
mechanical,
biological,
physicochemical
properties.
These
characteristics
allow
stimuli-responsive
hydrogels
provide
cutting-edge,
effective,
safe
treatment.
Constant
progress
field
necessitates
an
up-to-date
summary
of
current
trends
breakthroughs
biomedical
application
chitosan-based
was
aim
this
review.
General
data
about
sensitive
ions,
pH,
redox
potential,
light,
electric
field,
temperature,
magnetic
are
recapitulated.
Additionally,
responsive
multiple
stimuli
mentioned.
Focusing
multifaceted
thoroughly
described.
The
vast
spectrum
encompasses
neurological
disorders,
tumors,
wound
healing,
dermal
infections.
Available
chitosan
strongly
support
idea
that
approaches
developing
novel
solutions
worth
improving.
present
paper
constitutes
valuable
resource
researchers
practitioners
currently
field.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 3461 - 3473
Опубликована: Апрель 1, 2024
Purpose:
Ivosidenib
(IVO),
an
isocitrate
dehydrogenase-1
(IDH1)
used
for
treatment
of
acute
myeloid
leukemia
(AML)
and
cholangiocarcinoma.However,
poor
solubility,
low
bioavailability,
high
dose
side
effects
limit
clinical
application
IVO.Methods:
Ivosidenib-loaded
PLGA
nanoparticles
(IVO-PLGA-NPs)
chitosan
coated
(IVO-CS-PLGA-NPs)
were
prepared
using
emulsification
solvent
evaporation
method
the
liver
cancer.
Results:The
developed
IVO-PLGA-NPs
evaluated
their
particle
size
(171.7±4.9
nm),
PDI
(0.333),
ZP
(-23.0±5.8
mV),
EE
(96.3±4.3%),
DL
(9.66±1.1%);similarly,
IVO-CS-PLGA-NPs
(177.3±5.2
(0.311),
+25.9±5.7
mV,
(90.8±5.7%),
(9.42±0.7%).The
coating
was
evidenced
by
increase
in
mean
positive
value.Because
coating,
showed
a
more
stable
prolonged
release
IVO
than
IVO-PLGA-NPs.In
comparison
to
pure-IVO,
found
be
effective
against
HepG2
cells,
with
IC
50
values
MTT
assay
being
approximately
half
those
pure-IVO.In
expressions
caspase-3,
caspase-9,
p53
significantly
(p
<
0.05)
elevated.Conclusion:
Overall,
these
findings
suggest
that
improves
delivery
efficacy
ivosidenib
cancer
treatment.
