Molecular pathway approach in biotechnology DOI
Anton Buzdin,

Denis Kuzmin,

Ivana Jovčevska

и другие.

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 339 - 352

Опубликована: Дек. 6, 2024

Язык: Английский

Lessons learned from 20 years of preclinical testing in pediatric cancers DOI Creative Commons
Malcolm A. Smith,

Peter J. Houghton,

Richard B. Lock

и другие.

Pharmacology & Therapeutics, Год журнала: 2024, Номер 264, С. 108742 - 108742

Опубликована: Ноя. 5, 2024

Язык: Английский

Процитировано

2
Antibody–drug conjugates: prospects for the next generation DOI Creative Commons

Meriem Grairi,

Marc Le Borgne

Drug Discovery Today, Год журнала: 2024, Номер 29(12), С. 104241 - 104241

Опубликована: Ноя. 13, 2024

The concept of a 'magic bullet' was first introduced by Paul Ehrlich in the early 1900s, he foresaw advent targeted therapies and specific killing harmful cells and/or microorganisms. However, these were only used clinic after second half 20th century with development monoclonal antibodies. To date, 13 antibody-drug conjugates (ADCs) are commercially available. Many advances have been made modifying one or several three main components an ADC, namely antibody, cleavable non-cleavable linker payload, integrating conjugation chemistry. Despite efforts, some problems emerged thus limit their effectiveness. New strategies could overcome identify next generation ADC.

Язык: Английский

Процитировано

2
Humanized Recombinant Immunotoxin Targeting hCG Demonstrates Therapeutic Potential for Advanced Stage Difficult to Treat Cancers DOI
Kirti Nain,

Kritika Sonar,

Sibasis Sahoo

и другие.

Journal of drug targeting, Год журнала: 2024, Номер unknown, С. 1 - 14

Опубликована: Окт. 12, 2024

We report the development of an immunotherapeutic molecule, a humanized immunotoxin, for treating hCG-expressing advanced-stage cancers. PiPP, high-affinity anti-hCG monoclonal antibody, is used in immunotoxin 'homing' hCG-positive cancer cells. The deimmunized (DI) form α-Sarcin, fungal-origin toxin that lacks functional T-cell epitopes, design to ensure minimal immunogenicity repetitive use humans. A single-chain variable fragment (scFv) PiPP was constructed by linking VH and VL regions antibody. scFv part antibody further linked α-Sarcin at gene level expressed as recombinant protein E. coli. purified from bacterial cell lysate analyzed binding cytotoxicity hCG-secreting colorectal pancreatic results showed scFv(PiPP)-Sarcin able bind cells killed approximately 85% In vivo testing produced similar those vitro against adenocarcinoma-induced tumors. This could be promising agent colorectal, other terminal-stage

Язык: Английский

Процитировано

0
Molecular pathway approach in biotechnology DOI
Anton Buzdin,

Denis Kuzmin,

Ivana Jovčevska

и другие.

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 339 - 352

Опубликована: Дек. 6, 2024

Язык: Английский

Процитировано

0