Nanotherapeutics for Meningitis: Enhancing Drug Delivery Across the Blood-Brain Barrier

Biomimetics, Год журнала: 2025, Номер 10(1), С. 25 - 25

Опубликована: Янв. 3, 2025

Meningitis is the acute or chronic inflammation of protective membranes, surrounding brain and spinal cord, this inflammatory process spreads throughout subarachnoid space. The traditional drug delivery methods pose a disadvantage in limiting capacity crossing blood–brain barrier (BBB) to reach central nervous system (CNS). Hence, it imperative develop novel approaches that can overcome these constraints offer efficient therapy for meningitis. Nanoparticle (NP)-based therapeutic have potential address limitations such as penetrating BBB achieving targeted release specific cells tissues. This review highlights recent advancements nanotechnology-based approaches, functionalized polymeric nanoparticles, solid lipid nanoparticles (SLNs), nanostructured carriers, nanoemulsions, liposomes, transferosomes, metallic NPs treatment Recently, bionics has emerged next-generation technology development ideas from biological principles, structures, interactions neurological neuroinfectious diseases. Despite their potential, more studies are needed ensure safety efficacy NP-based systems focusing on critical aspects toxicity, immunogenicity, pharmacokinetics. Therefore, addresses current strategies innovative nanoparticle discusses future directions meningitis therapies.

Язык: Английский

Nanoparticle‐Based Therapeutics for Glioblastoma Multiforme Treatment

Advanced Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Abstract Glioblastoma multiforme (GBM) is a grade 4 primary malignant brain neoplasm with poor prognosis. GBM has an average survival of 12–18 months despite aggressive treatments, such as maximal safe resection, radiation, and chemotherapy temozolomide. always associated high incidences treatment resistance recurrence, which largely driven by glioma stem cells presents significant therapeutic challenges. The blood–brain barrier (BBB) the most obstacle in treating since it restricts delivery agents to tumor site. Recent advancements nanotechnology offer promising alternatives overcome restrictions, enabling targeted drug significantly reducing systemic toxicity. Additionally, discussing various types nanoparticles liposomes, lipid‐based, dendrimers, polymeric, metallic that have shown promise preclinical models for become pertinent. These can attach glioblastoma using antigens membrane receptors site‐directed targeting. Furthermore, potential cross BBB, enhancing minimizing off‐target effects. This review explores latest nanoparticle‐based therapies their revolutionize treatment, particularly through precise targeting controlled release within microenvironment.

Язык: Английский

Robotic microsurgery innovations: pioneering precision in delicate surgical procedures

International Journal of Surgery Open, Год журнала: 2024, Номер 62(6), С. 845 - 846

Опубликована: Окт. 15, 2024

Язык: Английский