Journal of Substance Use, Год журнала: 2023, Номер unknown, С. 1 - 7
Опубликована: Дек. 7, 2023
Introduction We examined COVID-19 trends and the socio-structural correlates of infections vaccinations among people who inject drugs (PWID).
Язык: Английский
International Journal of Drug Policy, Год журнала: 2024, Номер 126, С. 104356 - 104356
Опубликована: Фев. 23, 2024
Язык: Английский
Процитировано
9
The Lancet HIV, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Viruses, Год журнала: 2024, Номер 16(6), С. 885 - 885
Опубликована: Май 30, 2024
People living with HIV-HCV co-infection comprise a target group for HCV-micro-elimination. We conducted an HCV cascade of care (CoC) co-infected individuals in Greece and investigated factors associated different HCV-CoC stages. analyzed data from 1213 participants the Athens Multicenter AIDS Cohort Study. A seven-stage CoC, overall by subgroup (people who inject drugs (PWID), men having sex (MSM), women (MSW), migrants], was constructed, spanning diagnosis to sustained virologic response (SVR). Logistic/Cox regression models were employed identify passing through each CoC step. Among anti-HCV-positive individuals, 9.2% died before direct-acting antiviral (DAA) availability. PWID exhibited higher mortality rates than MSM. Of 1101 survivors, 72.2% remained underwent HCV-RNA testing. Migrants showed lowest retention rates. available 79.2% those care, 77.8% diagnosed chronic HCV. Subsequently, 71% initiated DAAs, very low CD4 counts (<100 cells/μL) exhibiting lower odds DAA initiation. SVR testing 203 85.7% achieving SVR. The did not differ across risk groups. In 2023, significant gaps between-group differences persisted among Greece.
Язык: Английский
Процитировано
1
Drugs Education Prevention and Policy, Год журнала: 2024, Номер unknown, С. 1 - 12
Опубликована: Июнь 5, 2024
Background Across Europe, harm reduction services experienced significant disruptions during the COVID-19 pandemic. This study analyses experiences of service providers pandemic in 34 European cities, focusing on their main challenges, adaptations, and opportunities for change. A closer examination Athens Dublin offers an in-depth look into these experiences.
Язык: Английский
Процитировано
1
HIV Medicine, Год журнала: 2024, Номер 25(10), С. 1135 - 1144
Опубликована: Июнь 20, 2024
Abstract Objectives HIV/hepatitis C virus (HCV) co‐infection among people who inject drugs (PWID) remains a global health problem. The goal of our study was to evaluate, in real‐world setting, success rates sustained virological response (SVR) using direct‐acting antivirals (DAAs) treat population PWID living with HCV/HIV. Methods This prospective single‐center observational study. We collected demographic, socioeconomic, and clinical data pertaining HIV HCV infection several barriers care. identified risk factors for SVR failure. Results Among 130 individuals retained care, we planned treatment 119/130 (91.5%); 106/119 (89.1%) started DAAs 100/106 (94.3%) completed treatment. People not starting were more often active opioid drug use (odds ratio [OR] 0.25; 95% confidence interval [CI] 0.07–0.97, p = 0.045) benzodiazepine abuse (OR CI 0.07–0.95, 0.042). Only 86/100 (86%) tested at 12 weeks (SVR12) 72/86 (83.7%) achieved SVR. substitution programmes tended return SVR12 testing (54.7% vs. 30%, 0.081). Individuals 0.226; 0.064–0.793, 0.02) or poor adherence 0.187; 0.043–0.814, 0.025) less likely achieve At the end period, 113/119 (95%) treatment‐eligible patients remained alive. cured 68/113 (61.1%) people. Conclusions Our findings underscore importance prioritizing combatting substance elimination goals. A systematic approach effort overcome receiving completing encourage enrol if possible completely abstain from use, can help increase chances cure.
Язык: Английский
Процитировано
1
Eurosurveillance, Год журнала: 2024, Номер 29(48)
Опубликована: Ноя. 28, 2024
Background Late HIV diagnosis (CD4 + T-cell count < 350 cells/μL, or with an AIDS-defining event) remains a persistent challenge in Greece, indicating potential missed opportunities (MOs) for earlier testing. Aim To determine the frequency of indicator conditions (ICs) preceding and to quantify MOs testing at nationwide level Greece. Methods This multicentre retrospective study analysed data on 823 antiretroviral therapy-naive adults (≥ 18 years) diagnosed during 2019–21. Medical records were reviewed identify pre-diagnosis healthcare contacts (HCCs) ICs justifying Univariable multivariable logistic regression identified factors associated ≥ 1 MO. A Bayesian model estimated time from seroconversion diagnosis. Results Among 517 participants HCC data, 249 had HCC. Of these, 59.0% (147/249) late presenters. These cases 365 HCCs, 191 (52.3%) The most common sexually transmitted infections (39.8%; 76/191) fever (11.0%; 21/191). Non-Greek origin was lower odds experiencing MO (adjusted ratio: 0.48; 95% CI: 0.22─1.02), while higher education increased early Median 3.2 years full sample 3.7 those HCC, about half latter reporting post-estimated seroconversion. Recognising would have potentially spared approximately year delay Conclusion prevalent Leveraging IC-guided addressing barriers could support treatment, limiting adverse health outcomes preventing transmission.
Язык: Английский
Процитировано
1
Infection Genetics and Evolution, Год журнала: 2024, Номер 121, С. 105597 - 105597
Опубликована: Апрель 23, 2024
New diagnoses of HIV-1 infection among people who inject drugs (PWID) in Athens, Greece, saw a significant increase 2011 and subsequent decline after 2013. Despite this, ongoing transmission persisted from 2014 to 2020 within this population. Our objective was estimate the time for PWID Athens following outbreak, explore patterns dispersal over time, determine duration diagnosis. Time diagnosis estimated 844 individuals infected 4 PWID-specific clusters 8 with sub-subtype A6 diagnosed during 2010–2019. Phylogeny reconstruction performed using maximum-likelihood method. dates were based on molecular clock calculations. In total 86 92 (93.5%) sequences 2016–2019 either related previously identified (n = 81) or belonged new cluster 5). The median between 0.42 years outbreak period 0.70 (p < 0.001). proportion clustered very low at 5.3% pre-outbreak (1998–2009), an 41.7% one year before 2010, consistently remained high whole 2011, spanning post-outbreak (2016–2019) range 92.9% 100%. substantial infections implies persistent 'slow burn' HIV suggesting that not successfully eliminated. since onset suggests persistence attributed injection practices. findings underscore importance targeted interventions PWID, considering rate prolonged
Язык: Английский
Процитировано
0
Journal of Viral Hepatitis, Год журнала: 2024, Номер 31(8), С. 466 - 476
Опубликована: Май 14, 2024
Abstract One of the World Health Organization's targets for 2030 viral hepatitis elimination strategy is to reduce new C (HCV) infections. In Athens, Greece, people who inject drugs (PWID) have a high HCV prevalence, with increasing trends since 2000s. This analysis aims assess primary incidence among PWID during 2012–2020. Two community‐based interventions were implemented in 2012–2013 and 2018–2020 repeated sero‐behavioural surveys each period. Participants enrolled multiple identified through linkage. To transmission, three indicators estimated: (i) anti‐HCV prevalence ‘new’ injectors (those injecting ≤2 years), (ii) indirect injectors, assuming infection occurred at midpoint between initiating injection first positive test, (iii) from repeat participants. There 431 125 respectively, 2018–2020. Αnti‐HCV [95% CI] declined 53.6% [48.8%, 58.3%] 40.0% [31.3, 49.1%] (25.4% reduction, p = .007). The estimate decreased 56.1 [49.3, 63.8] 39.0/100 person‐years (PYs) [29.6, 51.5] (30.5% .020). based on seroconversions participants (16/63 9/55 2018–2020) 64.6 [39.6105.4] 13.8/100 PYs [7.2, 26.5], respectively (78.6% < .001). Primary remains Athens. Consistent implementation combined interventions, including high‐coverage harm reduction programs initiatives tailored increase access treatment, essential sustain declining documented
Язык: Английский
Процитировано
0
The Journal of Infectious Diseases, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
The COVID-19 pandemic may have disproportionally impacted vulnerable groups such as people who inject drugs (PWID) through reduced healthcare services well social changes from mitigation measures. Understanding how the and associated strategies subsequently changed trajectory of hepatitis C virus (HCV) HIV transmission is critical to estimating disease burdens, identifying outbreak risk, developing informed intervention strategies.
Язык: Английский
Процитировано
0
Journal of Substance Use, Год журнала: 2023, Номер unknown, С. 1 - 7
Опубликована: Дек. 7, 2023
Introduction We examined COVID-19 trends and the socio-structural correlates of infections vaccinations among people who inject drugs (PWID).
Язык: Английский
Процитировано
0