Molecules,
Год журнала:
2017,
Номер
22(9), С. 1430 - 1430
Опубликована: Авг. 29, 2017
The
rapid
emergence
of
multidrug-resistant
pathogens
has
evolved
into
a
global
health
problem
as
current
treatment
options
are
failing
for
infections
caused
by
pan-resistant
bacteria.
Hence,
novel
antibiotics
in
high
demand,
and
this
reason
antimicrobial
peptides
(AMPs)
have
attracted
considerable
interest,
since
they
often
show
broad-spectrum
activity,
fast
killing
cell
selectivity.
However,
the
therapeutic
potential
natural
AMPs
is
limited
their
short
plasma
half-life.
Antimicrobial
peptidomimetics
mimic
structure
biological
activity
AMPs,
but
display
extended
stability
presence
matrices.
In
present
review,
focus
on
developments
reported
last
decade
with
respect
to
design,
synthesis,
cytotoxic
side
effects
well
applications
anti-infective
agents.
Specifically,
only
modular
residues
connected
via
amide
linkages
will
be
discussed.
These
comprise
classes
α-peptoids
(N-alkylated
glycine
oligomers),
β-peptoids
β-alanine
β3-peptides,
α/β3-peptides,
α-peptide/β-peptoid
hybrids,
α/γ
N-acylated
N-aminoethylpeptides
(AApeptides),
oligoacyllysines
(OAKs).
Such
particular
interest
due
potent
versatile
convenient
optimization
assembly
standard
solid-phase
procedures.
Frontiers in Immunology,
Год журнала:
2017,
Номер
8
Опубликована: Март 30, 2017
While
mesenchymal
stem
cells
(MSCs)-based
therapy
appears
to
be
promising,
there
are
concerns
regarding
possible
side
effects
related
the
unwanted
suppression
of
antimicrobial
immunity
leading
an
increased
risk
infection.
Conversely,
recent
data
show
that
MSCs
exert
strong
through
indirect
and
direct
mechanisms,
partially
mediated
by
secretion
peptides
proteins
(AMPs).
In
fact,
have
been
reported
increase
bacterial
clearance
in
pre-clinical
models
sepsis,
acute
respiratory
distress
syndrome
cystic
fibrosis
infections.
This
article
reviews
current
evidence
effector
function
MSCs,
focusing
mainly
on
role
MSCs-derived
AMPs.
The
strategies
might
modulate
expression
these
AMPs,
enhanced
effect
highlighted.
Furthermore,
studies
evaluating
presence
AMPs
cargo
extracellular
vesicles
(EVs)
underlined
as
perspective
opportunities
develop
new
drug
delivery
tools.
potential
EVs
can
also
heightened
cell
conditioning
and/or
loading.
Finally,
improving
pharmacokinetics
delivery,
addition
deciphering
multi-target
status
should
synergistically
lead
key
advances
against
infections
caused
resistant
strains.
动物学研究,
Год журнала:
2019,
Номер
40(6), С. 488 - 505
Опубликована: Янв. 1, 2019
The
discovery
of
antibiotics
marked
a
golden
age
in
the
revolution
human
medicine.
However,
decades
later,
bacterial
infections
remain
global
healthcare
threat,
and
return
to
pre-antibiotic
era
seems
inevitable
if
stringent
measures
are
not
adopted
curb
rapid
emergence
spread
multidrug
resistance
indiscriminate
use
antibiotics.
In
hospital
settings,
resistant
(MDR)
pathogens,
including
carbapenem-resistant
Pseudomonas
aeruginosa,
vancomycin-resistant
enterococci
(VRE),
methicillin-resistant
Staphylococcus
aureus
(MRSA),
extended-spectrum
β-lactamases
(ESBL) bearing
Acinetobacter
baumannii,
Escherichia
coli,
Klebsiella
pneumoniae
are
amongst
most
problematic
due
paucity
treatment
options,
increased
stay,
exorbitant
medical
costs.
Antimicrobial
peptides
(AMPs)
provide
an
excellent
potential
strategy
for
combating
these
threats.
Compared
empirical
antibiotics,
they
show
low
tendency
select
resistance,
killing
action,
broad-spectrum
activity,
extraordinary
clinical
efficacy
against
several
MDR
strains.
Therefore,
this
review
highlights
among
nosocomial
pathogens
its
implications
reiterates
importance
AMPs
as
next-generation
superbugs.
Molecules,
Год журнала:
2017,
Номер
22(9), С. 1430 - 1430
Опубликована: Авг. 29, 2017
The
rapid
emergence
of
multidrug-resistant
pathogens
has
evolved
into
a
global
health
problem
as
current
treatment
options
are
failing
for
infections
caused
by
pan-resistant
bacteria.
Hence,
novel
antibiotics
in
high
demand,
and
this
reason
antimicrobial
peptides
(AMPs)
have
attracted
considerable
interest,
since
they
often
show
broad-spectrum
activity,
fast
killing
cell
selectivity.
However,
the
therapeutic
potential
natural
AMPs
is
limited
their
short
plasma
half-life.
Antimicrobial
peptidomimetics
mimic
structure
biological
activity
AMPs,
but
display
extended
stability
presence
matrices.
In
present
review,
focus
on
developments
reported
last
decade
with
respect
to
design,
synthesis,
cytotoxic
side
effects
well
applications
anti-infective
agents.
Specifically,
only
modular
residues
connected
via
amide
linkages
will
be
discussed.
These
comprise
classes
α-peptoids
(N-alkylated
glycine
oligomers),
β-peptoids
β-alanine
β3-peptides,
α/β3-peptides,
α-peptide/β-peptoid
hybrids,
α/γ
N-acylated
N-aminoethylpeptides
(AApeptides),
oligoacyllysines
(OAKs).
Such
particular
interest
due
potent
versatile
convenient
optimization
assembly
standard
solid-phase
procedures.
