Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Июнь 25, 2022

Abstract Pseudomonas aeruginosa ( P. ) is a Gram-negative opportunistic pathogen that infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive pulmonary disorder (COPD), cancer, and severe infection requiring ventilation, such as COVID-19. also widely-used model bacterium for all biological areas. In addition to continued, intense efforts in understanding bacterial pathogenesis of including virulence factors (LPS, quorum sensing, two-component systems, 6 type secretion outer membrane vesicles (OMVs), CRISPR-Cas their regulation), rapid progress has been made further studying host-pathogen interaction, particularly host immune networks involving autophagy, inflammasome, non-coding RNAs, cGAS, etc . Furthermore, numerous technologic advances, bioinformatics, metabolomics, scRNA-seq, nanoparticles, drug screening, phage therapy, have used improve our defense. Nevertheless, much remains be uncovered about interactions between responses, mechanisms resistance by known or unannotated well mammalian cell signaling pathways. The widespread use antibiotics the slow development effective antimicrobials present daunting challenges necessitate new theoretical practical platforms screen develop mechanism-tested novel drugs treat intractable infections, especially those caused multi-drug strains. Benefited from advancing research tools technology, dissecting this pathogen’s feature entered into molecular mechanistic details dynamic holistic views. Herein, we comprehensively review discuss current status biophysical traits, behaviors, factors, invasive regulators, defense patterns against its infection, which point out directions future investigation add design and/or alternative therapeutics combat clinically significant pathogen.

Язык: Английский

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Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(6), С. 3128 - 3128

Опубликована: Март 18, 2021

Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF) contributing to morbidity and mortality. Its tremendous ability adapt greatly facilitates its capacity cause chronic infections. The adaptability flexibility of the are afforded by extensive number virulence factors it has at disposal, providing P. facility tailor response against different stressors environment. A deep understanding these mechanisms crucial for design therapeutic strategies vaccines this multi-resistant pathogen. Therefore, review describes main adaptations undergoes persist hostile environments such as CF respiratory tract. very large genome (5 7 MB) contributes considerably adaptive capacity; consequently, genomic studies have provided significant insights into elucidating evolution interactions host throughout course infection.

Язык: Английский

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Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis

Nature Reviews Microbiology, Год журнала: 2020, Номер 19(5), С. 331 - 342

Опубликована: Ноя. 19, 2020

Язык: Английский

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Microbiome Engineering: Synthetic Biology of Plant-Associated Microbiomes in Sustainable Agriculture

Trends in biotechnology, Год журнала: 2020, Номер 39(3), С. 244 - 261

Опубликована: Авг. 13, 2020

Mutualistic microbes associated with plants have enormous potential for economical and sustainable agriculture.There are two approaches to plant microbiome engineering: the bottom-up approach that involves isolating, engineering, reintroducing specific microbes, top-down synthetic ecology, using horizontal gene transfer a broad range of hosts in situ then phenotyping microbiome.Recent advances genome engineering tools, meta-omic computational genome-wide functional genomics can improve our ability engineer biocontrol, biofertilization, biostimulation, as well enhanced crop productivity yield.Various devices facilitate evaluation genetically modified before field studies.Robust biosafety, biosecurity, biocontainment strategies need be developed use environment. To support an ever-increasing population, modern agriculture faces numerous challenges pose major threats global food energy security. Plant-associated their many growth-promoting (PGP) traits, helping solve these challenges. However, results been variable, probably because poor colonization. Phytomicrobiome is emerging biology may offer ways alleviate this limitation. This review highlights recent both non-model bacteria microbiomes promote beneficial plant–microbe interactions, evaluate interactions. Biosafety, address environmental concerns also discussed. The United Nations estimates world population will 9.8 billion people by 2050 (https://population.un.org/wpp/). Agricultural must increase estimated 70% meet increasing demand food, feed, fiber, bioenergy (Global Productivity Initiative: https://globalagriculturalproductivity.org/). Because arable acreage unlikely grow [1.Bruinsma J. Crop production natural resource use.in: Bruinsma World Agriculture: Towards 2015/2030: An FAO Perspective. Earthscan Publications, 2003: 127-137Google Scholar], meeting requires achieving higher yields, currently attempted artificial fertilizers pesticides whose manufacture not sustainable. 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Rep. 6: 125-130Crossref Based ICE subtilis, Brophy coworkers created miniaturized (mini-ICEBs1) delivery wide Firmicutes collected humans soil, variable (10−1 10−7 conjugations per donor) 3D) demonstrated (XPORT) 10 synthetically defined consortium situ, there four six s

Язык: Английский

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Environmental antibiotics and resistance genes as emerging contaminants: Methods of detection and bioremediation

Current Research in Microbial Sciences, Год журнала: 2021, Номер 2, С. 100027 - 100027

Опубликована: Март 15, 2021

In developing countries, the use of antibiotics has helped to reduce mortality rate by minimizing deaths caused pathogenic infections, but costs antibiotic contamination remain a major concern. Antibiotics are released into environment, creating complicated environmental problem. used in human, livestock and agriculture, contributing its escalation environment. Environmental pose range risks have significant effects on human animal health. Nevertheless, this is result development antibiotic-resistant multi-drug-resistant bacteria. area health care, husbandry crop processing, imprudent drugs produces This threat deepest world, with an estimated 700,000 people suffering from infections each year. The study explores how bacteria wide variety resistance mechanism these approaches impact environment our paper focuses processes which degrade, emerging contaminants, tolerance antibiotics.

Язык: Английский

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Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Veterinary Sciences, Год журнала: 2020, Номер 7(3), С. 110 - 110

Опубликована: Авг. 13, 2020

The increasing demand for animal-derived foods has led to intensive and large-scale livestock production with the consequent formation of large amounts manure. Livestock manure is widely used in agricultural practices as soil fertilizer worldwide. However, several antibiotic residues, resistance genes (ARGs) antibiotic-resistant bacteria are frequently detected manure-amended soils. This review explores role persistence dissemination ARGs environment, analyzes procedures decrease antimicrobial potential impact application public health. We highlight that shows unique features a hotspot gene by horizontal transfer events: richness nutrients, high abundance diversity populations residues may exert selective pressure on trigger mobilization; reduction methodologies able reduce concentrations some, but not all, antimicrobials microorganisms. Conjugation events often seen even after composting. Antibiotic considered growing threat human, animal environmental Therefore, it crucial amount load resistant end up soil.

Язык: Английский

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The Role of Integrative and Conjugative Elements in Antibiotic Resistance Evolution

Trends in Microbiology, Год журнала: 2020, Номер 29(1), С. 8 - 18

Опубликована: Июнь 11, 2020

Язык: Английский

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Treatment options for K. pneumoniae, P. aeruginosa and A. baumannii co-resistant to carbapenems, aminoglycosides, polymyxins and tigecycline: an approach based on the mechanisms of resistance to carbapenems

Infection, Год журнала: 2020, Номер 48(6), С. 835 - 851

Опубликована: Сен. 1, 2020

Язык: Английский

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Use of Essential Oils to Counteract the Phenomena of Antimicrobial Resistance in Livestock Species

Antibiotics, Год журнала: 2024, Номер 13(2), С. 163 - 163

Опубликована: Фев. 7, 2024

Antimicrobial resistance is an increasingly widespread phenomenon that of particular concern because the possible consequences in years to come. The dynamics leading microbial strains are diverse, but certainly include incorrect use veterinary drugs both terms dosage and timing administration. Moreover, drug often administered absence a diagnosis. Many active ingredients pharmaceutical formulations are, therefore, losing their efficacy. In this situation, it imperative seek alternative treatment solutions. Essential oils mixtures compounds with different pharmacological properties. They have been shown possess antibacterial, anti-parasitic, antiviral, regulatory properties numerous metabolic processes. abundance molecules they contain makes difficult for treated species develop resistance. Given natural origin, environmentally friendly show little or no toxicity higher animals. There several published studies on essential as antimicrobials, present literature has not adequately summarized manuscript. This review aims shed light results achieved by scientific community regarding treat main agents bacterial infection interest livestock. Google Scholar, PubMed, SciELO, SCOPUS databases were used search selection studies. manuscript lay foundations new strategy more less prone emergence phenomena.

Язык: Английский

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Antibiotic contamination in wastewater treatment plant effluents: Current research and future perspectives

Environmental Nanotechnology Monitoring & Management, Год журнала: 2025, Номер unknown, С. 101047 - 101047

Опубликована: Янв. 1, 2025

Язык: Английский

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