Critical Reviews in Biotechnology,
Год журнала:
2024,
Номер
unknown, С. 1 - 21
Опубликована: Ноя. 26, 2024
The
biomolecular
condensates
(BCs)
formed
by
proteins
through
phase
separation
provide
the
necessary
space
and
raw
materials
for
orderly
progression
of
cellular
activities,
on
this
basis,
various
membraneless
organelles
(MLOs)
are
formed.
occurrence
eukaryotic
is
driven
multivalent
interactions
from
intrinsically
disordered
regions
(IDRs)
and/or
specific
protein/nucleic
acid
binding
domains
regulated
environmental
factors.
In
plant
animal
cells,
MLOs
involved
in
gene
expression
regulation,
stress
response,
mitotic
control
display
similar
functions
mechanisms.
contrast,
related
to
reproductive
development
immune
regulation
differs
significantly
between
two
kingdoms
owing
their
distinct
cell
structures
nutritional
patterns.
addition,
animals
plants
each
exhibit
unique
protein
such
as
neural
light
signal
response.
By
comparing
similarities
differences
formation
mechanism
functional
known
separation,
we
elucidated
its
importance
evolution,
differentiation,
adaptation
both
plants.
significance
studying
enhancing
biological
quality
life
has
been
further
emphasized.
Pharmacological Research,
Год журнала:
2024,
Номер
210, С. 107495 - 107495
Опубликована: Ноя. 3, 2024
Antibiotic
resistance
is
a
global
health
concern
that
rapidly
spreading
among
human
and
animal
pathogens.
Developing
novel
antibiotics
one
of
the
most
significant
approaches
to
surmount
antibiotic
resistance.
Given
difficult
in
identifying
targets,
cryptic
binding
sites
provide
new
pockets
for
compounds
design
combat
However,
there
exists
lack
comprehensive
analysis
discussion
on
successful
utilization
overcoming
Here,
we
systematically
analyze
crucial
role
neutralizing
First,
development
associated
mechanisms
are
summarized.
Then,
advantages
were
discussed.
Specific
resistant
proteins
case
studies
designed
inhibitors
exemplified.
This
review
provides
insight
into
discovery
drug
as
an
approach
overcome
2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 5, 2023
Structure-based
identification
of
protein-ligand
binding
sites
plays
a
crucial
role
in
the
initial
stages
rational
drug
discovery
pipelines.
As
machine
learning
methods
are
increasingly
integrated
into
process,
significant
challenge
arises
while
training
these
methods,
as
labeled
data
typically
derived
from
ligand-bound
structures.
Consequently,
struggle
to
detect
within
proteins
where
site
is
concealed
absence
bound
ligand.
Here,
we
explore
possibility
harnessing
protein
language
models
address
this
issue
and
compare
their
performance
against
state-of-the-art
both
those
specialized
cryptic
(CBS)
detection
that
not.
We
show
applying
pre-trained
protein-language
relatively
straightforward
manner
enables
us
surpass
CBS
prediction.
Critical Reviews in Biotechnology,
Год журнала:
2024,
Номер
unknown, С. 1 - 21
Опубликована: Ноя. 26, 2024
The
biomolecular
condensates
(BCs)
formed
by
proteins
through
phase
separation
provide
the
necessary
space
and
raw
materials
for
orderly
progression
of
cellular
activities,
on
this
basis,
various
membraneless
organelles
(MLOs)
are
formed.
occurrence
eukaryotic
is
driven
multivalent
interactions
from
intrinsically
disordered
regions
(IDRs)
and/or
specific
protein/nucleic
acid
binding
domains
regulated
environmental
factors.
In
plant
animal
cells,
MLOs
involved
in
gene
expression
regulation,
stress
response,
mitotic
control
display
similar
functions
mechanisms.
contrast,
related
to
reproductive
development
immune
regulation
differs
significantly
between
two
kingdoms
owing
their
distinct
cell
structures
nutritional
patterns.
addition,
animals
plants
each
exhibit
unique
protein
such
as
neural
light
signal
response.
By
comparing
similarities
differences
formation
mechanism
functional
known
separation,
we
elucidated
its
importance
evolution,
differentiation,
adaptation
both
plants.
significance
studying
enhancing
biological
quality
life
has
been
further
emphasized.
