Phytotherapy Research,
Год журнала:
2023,
Номер
38(3), С. 1173 - 1190
Опубликована: Дек. 20, 2023
Abstract
Cancer
cells
often
exhibit
defects
in
the
execution
of
cell
death,
resulting
poor
clinical
outcomes
for
patients
with
many
cancer
types.
Ferroptosis
is
a
newly
discovered
form
programmed
death
characterized
by
intracellular
iron
overload
and
lipid
peroxidation
membrane.
Increasing
evidence
suggests
that
ferroptosis
closely
associated
wide
variety
physiological
pathological
processes,
particularly
cancer.
Notably,
various
bioactive
natural
products
have
been
shown
to
induce
initiation
cells,
thereby
exerting
anticancer
effects.
In
this
review,
we
summarize
core
regulatory
mechanisms
multifaceted
roles
Importantly,
focus
on
regulate
such
as
terpenoids,
polyphenols,
alkaloids,
steroids,
quinones,
polysaccharides.
The
efficacy,
adverse
effects,
drug–drug
interactions
these
need
be
evaluated
further
high‐quality
studies
accelerate
their
application
treatment.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Дек. 21, 2024
Lenvatinib
is
a
multi-target
tyrosine
kinase
inhibitor
widely
used
in
the
treatment
of
hepatocellular
carcinoma
(HCC).
Its
primary
mechanism
action
involves
inhibiting
signal
pathways
such
as
vascular
endothelial
growth
factor
receptors
(VEGFR)
and
fibroblast
(FGFR),
thereby
reducing
tumor
cell
proliferation
angiogenesis
affecting
tumor's
immune
microenvironment.
In
liver
cancer,
although
lenvatinib
monotherapy
has
shown
good
clinical
effect,
problem
drug
resistance
becoming
more
serious.
This
may
be
caused
by
variety
factors,
including
genetic
mutations,
signaling
pathway
remodeling,
changes
order
to
overcome
resistance,
combination
other
therapeutic
strategies
gradually
become
research
hotspot,
it
worth
noting
that
checkpoint
inhibitors
(ICIs)
application
prospect.
not
only
enhances
anti-tumor
response
but
also
helps
improve
efficacy.
However,
therapy
faces
challenges
regarding
safety
tolerability.
Therefore,
studying
mechanisms
identifying
relevant
biomarkers
particularly
important,
aids
early
diagnosis
personalized
treatment.
article
reviews
treating
efficacy
its
with
inhibitors,
causes
exploration
biomarkers,
novel
for
lenvatinib.
We
hope
provide
insights
into
use
scientific
settings,
offering
new
cancer.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2025,
Номер
44(1)
Опубликована: Янв. 21, 2025
Abstract
Background
Triggering
receptor
expressed
on
myeloid
cells
2
(TREM2),
a
surface
predominantly
cells,
is
major
hub
gene
in
pathology-induced
immune
signaling.
However,
its
function
hepatocellular
carcinoma
(HCC)
remains
controversial.
This
study
aimed
to
evaluate
the
role
of
TREM2
tumor
microenvironment
context
HCC
progression.
Methods
was
experimentally
induced
wild-type
(WT)
and
Trem2
-deficient
(
−/−
)
mice,
clinical
sample
analysis
vitro
studies
macrophages
were
conducted.
treated
with
conditioned
medium
from
WT
or
macrophages,
their
malignant
phenotypes
underlying
mechanisms
analyzed.
Results
deficiency
reduced
liver
burden
orthotopic
subcutaneous
models
by
altering
CD8
+
T
cell
infiltration.
presented
increased
chemokine
secretion.
TGF-β1
found
be
positively
correlated
expression
HCC,
TGF-β
blockade
reversed
induction.
On
other
hand,
associated
glycolysis
PKM2
cells;
this
association
may
related
secretion
IL-1β,
which
enhances
cells.
Conclusions
These
results
reveal
that
play
driving
progression
suppressing
infiltration
promoting
glycolysis,
providing
new
therapeutic
target
for
HCC.
Molecular Medicine,
Год журнала:
2025,
Номер
31(1)
Опубликована: Фев. 20, 2025
Metabolic
reprogramming
is
a
hallmark
of
hepatocellular
carcinoma
(HCC)
progression,
driving
aberrant
cellular
processes
in
response
to
pathological
stimuli.
While
dihydrolipoyl
transacetylase
(DLAT)
has
been
implicated
the
development
various
cancers,
its
specific
role
and
underlying
mechanisms
HCC
remain
unclear.
This
study
aimed
investigate
expression,
function,
mechanistic
impact
DLAT
HCC.
A
comprehensive
analysis
was
conducted
using
RNA
sequencing
data,
tissue
microarrays,
vitro
vivo
functional
assays,
studies
evaluate
tumor
associated
molecular
pathways
Our
revealed
significant
upregulation
expression
HCC,
which
linked
poor
prognosis.
Furthermore,
we
discovered
that
facilitated
metastasis
by
metabolic
cells.
Mechanistically,
found
enhance
glucose
transporter
1
(GLUT1)
via
H3K18
acetylation,
thereby
promoting
aerobic
glycolysis
epithelial-to-mesenchymal
transition
(EMT),
subsequently
augmented
both
vivo.
Finally,
confirmed
positive
correlation
between
GLUT1
tissues.
These
findings
establish
as
key
regulator
progression
suggest
potential
promising
predictive
biomarker
therapeutic
target
for
improving
diagnosis
treatment.
Experimental Cell Research,
Год журнала:
2025,
Номер
unknown, С. 114492 - 114492
Опубликована: Фев. 1, 2025
Osteosarcoma,
a
primary
malignant
bone
tumor
predominantly
affecting
children
and
adolescents,
is
characterized
by
aerobic
glycolysis,
which
intricately
linked
to
progression
metastasis,
yet
its
prognostic
implications
remain
underexplored.
This
study
aimed
develop
model
utilizing
glycolysis-related
genes
elucidate
the
functional
role
of
P4HA1,
key
gene
within
this
model,
in
osteosarcoma
prognosis
immune
cell
infiltration.
We
collected
clinical
transcriptomic
data
from
patients
UCSC
Xena
GEO
databases.
Through
univariate
Cox
LASSO
regression
analyses,
we
identified
12
that
significantly
influence
prognosis.
These
were
employed
construct
risk
score
accurately
predicted
patient
outcomes
as
demonstrated
survival
analysis
ROC
curves,
with
an
AUC
0.899,
0.881,
0.878
for
1-year,
3-year,
5-year
predictions,
respectively.
The
was
particularly
effective
across
different
subgroups.
Immune
infiltration
revealed
CD8+
T
cells,
naïve
CD4+
resting
dendritic
activated
mast
cells
contributed
model's
predictive
power.
also
showed
significant
enrichment
immune-related
signaling
pathways,
indicating
robust
association
between
status
glycolytic-related
scores
Notably,
P4HA1
upregulated
tissues
promoted
proliferation
glycolysis-dependent
manner,
evidenced
increased
intracellular
ATP
levels,
inhibited
glucose
absorption,
elevated
lactate
levels
P4HA1-overexpressing
cells.
promotion
could
be
attenuated
glycolysis
inhibitor
2-DG,
highlighting
dependency
P4HA1's
action.
In
conclusion,
developed
integrating
genes,
particular
emphasis
on
P4HA1.
Our
findings
highlight
interplay
disease
provides
insights
targeted
therapies
foundation
further
research
into
treatment.
Molecular Medicine,
Год журнала:
2025,
Номер
31(1)
Опубликована: Апрель 22, 2025
Abstract
In
the
clinical
management
of
cancers,
emergence
chemoresistance
represents
a
profound
and
imperative
“pain
point”
that
requires
immediate
attention.
Understanding
mechanisms
is
essential
for
developing
effective
therapeutic
strategies.
Importantly,
existing
studies
have
demonstrated
glucose
metabolic
reprogramming,
commonly
referred
to
as
Warburg
effect
or
aerobic
glycolysis,
major
contributor
chemoresistance.
Additionally,
lactate,
byproduct
functions
signaling
molecule
supports
lysine
lactylation
modification
proteins,
which
also
plays
critical
role
in
However,
it
insufficient
discuss
glycolysis
from
single
perspective.
The
intricate
relationship
between
crucial
promoting
Thus,
thorough
elucidation
underlying
mediated
by
essential.
This
review
provides
comprehensive
overview
these
further
outlines
exert
synergistic
effects,
development
creating
positive
feedback
loop
continues
mediate
this
resistance.
close
link
suggests
application
glycolysis-related
drugs
inhibitors
cancer
therapy
may
represent
promising
anticancer
strategy.
Furthermore,
targeted
lactylation,
either
alone
combination
with
other
treatments,
offer
new
avenues
overcoming
