Tailoring traditional Chinese medicine in cancer therapy

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 21, 2025

Язык: Английский

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Interleukin-6 (IL-6)-associated tumor microenvironment remodelling and cancer immunotherapy

Cytokine & Growth Factor Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Traditional Chinese medicine for the treatment of cancers of hepatobiliary system: from clinical evidence to drug discovery

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Окт. 1, 2024

Язык: Английский

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Cancer therapy resistance mediated by cancer-associated fibroblast-derived extracellular vesicles: biological mechanisms to clinical significance and implications

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Сен. 7, 2024

Cancer-associated fibroblasts (CAFs) are a diverse stromal cell population within the tumour microenvironment, where they play fundamental roles in cancer progression and patient prognosis. Multiple lines of evidence have identified that CAFs critically involved shaping structure function microenvironment with numerous functions regulating behaviours, such as metastasis, invasion, epithelial-mesenchymal transition (EMT). can interact extensively cells by producing extracellular vesicles (EVs), multiple secreted factors, metabolites. Notably, CAF-derived EVs been critical mediators therapy resistance, constitute novel targets biomarkers management. This review aimed to summarize biological detailed molecular mechanisms mediating resistance chemotherapy, targeted agents, radiotherapy, immunotherapy. We also discussed therapeutic potential clinical management, thereby providing strategy for enhancing efficacy improving

Язык: Английский

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Targeting ferroptosis in gastrointestinal tumors: Interplay of iron-dependent cell death and autophagy

Molecular and Cellular Probes, Год журнала: 2025, Номер 79, С. 102013 - 102013

Опубликована: Янв. 24, 2025

Язык: Английский

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Investigating autophagy and intricate cellular mechanisms in hepatocellular carcinoma: Emphasis on cell death mechanism crosstalk

Cancer Letters, Год журнала: 2024, Номер 588, С. 216744 - 216744

Опубликована: Март 1, 2024

Hepatocellular carcinoma (HCC) stands as a formidable global health challenge due to its prevalence, marked by high mortality and morbidity rates. This cancer type exhibits multifaceted etiology, prominently linked viral infections, non-alcoholic fatty liver disease, genomic mutations. The inherent heterogeneity of HCC, coupled with proclivity for developing drug resistance, presents obstacles effective therapeutic interventions. Autophagy, fundamental catabolic process, plays pivotal role in maintaining cellular homeostasis, responding stressors such nutrient deprivation. In the context tumor cells exploit autophagy, either augmenting or impeding activity, thereby influencing tumorigenesis. comprehensive review underscores dualistic autophagy acting both pro-survival pro-death mechanism, impacting trajectory anti-carcinogenic potential is evident ability enhance apoptosis ferroptosis HCC cells. Pertinently, dysregulated fosters resistance carcinogenic context. Both epigenetic factors can regulate progression. Recognizing paramount importance progression, this introduces pharmacological compounds capable modulating autophagy—either inducing inhibiting it, promising avenues therapy.

Язык: Английский

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Multifunctional and stimuli-responsive liposomes in hepatocellular carcinoma diagnosis and therapy

Translational Oncology, Год журнала: 2024, Номер 45, С. 101975 - 101975

Опубликована: Апрель 30, 2024

Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer, mainly occurring in Asian countries with an increased incidence rate globally. Currently, several kinds therapies have been deployed for HCC therapy including surgical resection, chemotherapy, radiotherapy and immunotherapy. However, this tumor still incurable, requiring novel strategies its treatment. The nanomedicine has provided new insights regarding treatment cancer that liposomes as lipid-based nanoparticles, widely applied due to their biocompaitiblity, high drug loading ease synthesis modification. current review evaluates application therapy. drugs genes lack targeting ability into tissues cells. Therefore, or on can increase accumulation site suppression. Moreover, stimuli-responsive pH-, redox- light-sensitive are able deliver microenvironment improve therapeutic index. Since a number receptors upregulate cells, functionalization lactoferrin peptides promote towards phototherapy be induced by through phtoosensitizers stimulate photothermal- photodynamic-driven ablation Overall, findings line fact promising nanocarriers HCC.

Язык: Английский

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Plant-Derived Molecules Modulate Multidrug Resistance in Gastrointestinal Cancers: A Comprehensive Review

Applied Sciences, Год журнала: 2025, Номер 15(3), С. 1125 - 1125

Опубликована: Янв. 23, 2025

Multidrug resistance (MDR) development against cytotoxic drugs by tumor cells is one of the main causes treatment failure in gastrointestinal cancers, a group cancers great relevance due to their prevalence and/or mortality. This phenomenon mediated diverse mechanisms, including overexpression members superfamily membrane transporters ATP-binding cassette (ABC). Most these molecules, P-glycoprotein (P-gp or MDR1/ABCB), MDR-associated protein 1 (MRP1/ABCC1), MRP2, and breast cancer (BCRP/ABCG2), are integrated cell membrane, acting as drug efflux pumps. Despite use various MDR modulators adjuvants improve chemotherapy response, results have not been satisfactory. Natural products from plants, such flavonoids, alkaloids, terpenoids, coumarins, capable modifying resistance, suggesting an improvement antitumoral effect current treatments without generating side effects. review aims provide overview most recent studies relation plant-derived molecules extracts that modulate antitumor could be applied future clinical practice patients with cancer.

Язык: Английский

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Flavonoids as modulators of miRNA expression in pancreatic cancer: Pathways, Mechanisms, And Therapeutic Potential

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117347 - 117347

Опубликована: Сен. 5, 2024

Язык: Английский

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Bufalin CaCO₃ Nanoparticles Triggered Pyroptosis through Calcium Overload via Na⁺/Ca²⁺ Exchanger Reverse for Cancer Immunotherapy

Nano Letters, Год журнала: 2024, Номер unknown

Опубликована: Сен. 30, 2024

Bufalin is a promising active ingredient in traditional Chinese medicine but has shown limited anticancer applications due to its toxicity. Here, we report BCNPs@gel, bufalin-containing CaCO

Язык: Английский

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