Artificial intelligence in tumor drug resistance: Mechanisms and treatment prospects
Опубликована: Фев. 1, 2025
Язык: Английский
PARP inhibition elicits NK cell-associated immune evasion via potentiating HLA-G expression in tumor
Drug Resistance Updates,
Год журнала:
2025,
Номер
unknown, С. 101247 - 101247
Опубликована: Апрель 1, 2025
Язык: Английский
Mobocertinib antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells: in vitro and in vivo studies
Cancer Letters,
Год журнала:
2024,
Номер
unknown, С. 217309 - 217309
Опубликована: Окт. 1, 2024
Язык: Английский
Multidrug resistance transporters P-gp and BCRP limit the efficacy of ATR inhibitor ceralasertib in cancer cells
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 2, 2024
The
therapeutic
effect
of
chemotherapy
and
targeted
therapy
are
known
to
be
limited
by
drug
resistance.
Substantial
evidence
has
shown
that
ATP-binding
cassette
(ABC)
transporters
P-gp
BCRP
significant
contributors
multidrug
resistance
(MDR)
in
cancer
cells.
In
this
study,
we
demonstrated
a
clinical-staged
ATR
inhibitor
ceralasertib
is
susceptible
BCRP-mediated
MDR.
resistant
cells
were
less
sensitive
compared
the
parental
Moreover,
can
reversed
inhibiting
efflux
activity
BCRP.
Interestingly,
was
able
downregulate
level
but
not
BCRP,
suggesting
potential
regulation
between
signaling
expression.
Furthermore,
computational
docking
analysis
predicted
high
affinities
drug-binding
sites
summary,
overexpression
sufficient
confer
ceralasertib,
underscoring
their
role
as
biomarkers
for
efficacy.
Язык: Английский
CYP1B1 Promotes PARPi-Resistance via Histone H1.4 Interaction and Increased Chromatin Accessibility in Ovarian Cancer
Drug Resistance Updates,
Год журнала:
2024,
Номер
77, С. 101151 - 101151
Опубликована: Сен. 12, 2024
Язык: Английский
Role of solute carrier transporters in ovarian cancer (Review)
International Journal of Molecular Medicine,
Год журнала:
2024,
Номер
55(2)
Опубликована: Ноя. 27, 2024
Solute
carrier
(SLC)
transporters
are
involved
in
various
biological
processes
associated
with
metabolic
reprogramming
and
cancer,
supporting
the
increased
requirement
of
nutrients
energy.
Over
past
decade,
there
have
been
significant
advancements
understanding
expression
function
SLCs
ovarian
cancer
(OC).
This
gynecological
condition
has
a
high
mortality
rate
limited
treatment
options;
thus,
early
diagnosis
remains
target
clinically.
OC
exhibits
complexity
heterogeneity,
resulting
different
clinical
characteristics,
resistance
to
chemotherapy
drugs
poor
prognosis.
Additionally,
pattern
between
healthy
tumor
tissue,
consequently,
their
inhibition
or
activation
could
modify
signaling
pathways
growth
process,
such
as
cell
proliferation,
apoptosis
drug
accumulation.
The
present
review
aims
consolidate
current
data
provide
comprehensive
potential
importance
OC.
it
seeks
offer
guidance
for
further
research
on
utilizing
prognostic
biomarkers
therapeutic
targets.
Язык: Английский
Editorial: ABC transporters and drug resistance
Drug Resistance Updates,
Год журнала:
2024,
Номер
77, С. 101135 - 101135
Опубликована: Авг. 10, 2024
Язык: Английский
ABCG2 Gene Expression in Non-Small Cell Lung Cancer
Biomedicines,
Год журнала:
2024,
Номер
12(10), С. 2394 - 2394
Опубликована: Окт. 19, 2024
Background/Objectives:
ATP-binding
cassette
subfamily
G
member
2
[ABCG2/breast
cancer
resistance
protein
(BCRP)]
contributes
to
mechanisms
of
multidrug
(MDR)
and
is
a
marker
side
population
(SP)
cells
in
human
cancers.
The
primary
objective
this
study
was
investigate
the
impact
ABCG2
gene
expression
on
non-small
cell
lung
(NSCLC)
development,
course
disease,
patient
prognosis
using
publicly
available
data.
Obtained
results
were
supplemented
with
assessment
blood
NSCLC
patients.
Methods:
dataset
analyzed
utilizing
TIMER
2.0,
UALCAN,
TNMplot,
MEXPRESS,
cBioPortal,
MethSurv,
KM
Plotter,
STRING,
ShinyGO
0.80
databases.
Blood
samples
from
50
patients
assessed
real-time
PCR
method.
Results:
expressed
at
low
level
NSCLC,
did
not
correlate
clinical
aggressiveness
cancer.
Higher
improved
overall
survival,
but
only
LUAD.
In
addition,
CpG
sites
located
island
affecting
patient’s
indicated.
case
our
own
laboratory
results,
reveal
any
changes
levels
collected
different
time
points
during
diagnostic–therapeutic
procedure.
silico
analysis,
most
interactors
associated
development
drug
resistance.
Conclusions:
appears
have
particularly
significant
survival
effect
immunotherapy
related
immune
infiltration.
Presented
findings
may
support
personalized
medicine
strategies
based
bioinformatics
findings.
Язык: Английский