Biomaterials, Год журнала: 2024, Номер 316, С. 123028 - 123028
Опубликована: Дек. 15, 2024
Язык: Английский
Biomarker Research, Год журнала: 2025, Номер 13(1)
Опубликована: Март 12, 2025
Abstract The cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) signaling pathway plays a crucial role in activating innate and specific immunity anti-tumor immunotherapy. As the major infiltrating cells tumor microenvironment (TME), tumor-associated macrophages (TAMs) could be polarized into either M1 or pro-tumor M2 types based on various stimuli. Accordingly, targeted reprogramming TAMs to restore immune balance shows promise as an effective strategy. In this review, we aim target cGAS-STING for enhance We investigated double-edged sword effects of regulating TME. regulative roles its impact TME were further revealed. More importantly, several strategies targeting designed enhancing Taken together, might promising strategy
Язык: Английский
Процитировано
1
Oncogene, Год журнала: 2024, Номер 43(36), С. 2737 - 2749
Опубликована: Авг. 7, 2024
Язык: Английский
Процитировано
6
Nanoscale, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy characterized by limited treatment options and poor prognosis. Nanoparticle-based drug delivery systems have emerged as a promising strategy to enhance cancer therapy efficacy improving targeting, reducing toxicity, enabling multifunctional applications. This review highlights some key types of nanoparticles, including liposomes, polymeric metallic dendrimers, quantum dots, which could effectively improve the various drugs used in chemotherapy, radiotherapy, immunotherapy, offering more precise effective options. With ability stability overcome biological barriers, nanoparticle-based represent transformative for ESCC treatment. Despite challenges, such biocompatibility scalability, future holds great promise, particularly development personalized nanomedicine novel therapeutic approaches targeting tumor microenvironment. ongoing advancements, hold immense potential revolutionize patient outcomes.
Язык: Английский
Процитировано
0
Frontiers in Oncology, Год журнала: 2025, Номер 15
Опубликована: Март 11, 2025
Esophageal carcinoma (ESCA) is a highly malignant tumor with the highest incidence in Eastern Asia. Although treatment modalities for ESCA have advanced recent years, overall prognosis remains poor, as most patients are diagnosed at an stage of disease. There urgent need to promote early screening increase survival rates and improve patient outcomes. The development closely linked complex microenvironment (TME), where chemokines their receptors play pivotal roles. Chemokines class small-molecule, secreted proteins constitute largest family cytokines. They not only directly regulate growth proliferation but also influence cell migration localization through specific receptor interactions. Consequently, affect invasion metastatic spread. Furthermore, immune cells, including macrophages regulatory T within TME. recruitment these cells further leads immunosuppression, creating favorable conditions metastasis. This review examines impact ESCA-associated on ESCA, emphasizing critical involvement
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2025, Номер 13(4), С. 890 - 890
Опубликована: Апрель 7, 2025
Background: Chemoresistance is an existing challenge faced in the treatment of hairy cell leukemia variant (HCL-v). Classical (HCL-c) very sensitive to standard care with purine nucleoside analogs (PNAs) cladribine (cDa) and pentostatin. However, almost half these patients eventually become less chemotherapy relapse. HCL-variant (HCL-v) a biologically distinct entity from HCL-c that not frontline PNA therapy, this recommended for patients. To address challenges, we investigated role B-cell activating factor (BAFF) promoting HCL-v chemoresistance. Methods: Flow cytometry quantitative PCR were used measure levels BAFF its receptors. determine activated pathways HCL-v, Bonna-12 line or patient-derived cancer cells stimulated recombinat activation common BAFF-activated pathways, including nonclassical nuclear kappa B (NF-κB) pathway, Extracellular Signal-Regulated Kinase (Erk) phosphatidylinositol-3 (PI-3) kinase (PI3K)/AKT serine/threonine (AKT) measured by western blotting. test whether signaling promotes chemoresistance performed RNA sequencing. Lastly, confirm functional implications treated exogenous before cladribine. Results: We found express receptors at varying degrees relatively lower membrane-bound ligand expression. stimulation resulted substantial NF-κB which known promote anti-apoptotic pro-survival effects cancers. Conversely, line, observed constitutive pathway. Through sequencing, upregulates myriad genes are various cancers, IL1, CXCL1/2, CXCL5, CXCL8, TRAF3, PTGS2. protects cladribine-induced death vitro. Conclusions: conclude provides chemo-protection signaling, results upregulation multiple genes. Our highlight important resistance suggest blockade may enhance chemosensitivity PNAs drug-resistant
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 24, 2025
Abstract As an emerging technology for modeling cancer tissue in vitro, 3D bioprinting facilitates precise spatial manipulation of cells and biomaterials, allowing the replication complex architectures accurate recapitulation tumor microenvironment (TME) features. This review initially elucidates mechanisms underlying tumorigenesis associated TME complexity, with a particular focus on roles stromal cell populations characteristics extracellular matrix (ECM) progression. Moreover, this work summarizes recent advances bioprinted models, emphasizing their application studying cell‐ECM interactions, stromal‐tumor crosstalk, vasculature formation investigating occurrence metastasis, as well utility high‐throughput drug screening therapeutic development. Finally, discusses advantages challenges creating biomimetic while providing insights into future development trajectories potential translational applications research personalized medicine. By focusing these critical dimensions, aims to highlight transformative role advancing vitro models ultimate goal improving treatment, prevention, patient outcomes.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Сен. 2, 2024
Tumor-associated macrophages (TAMs), fundamental constituents of the tumor microenvironment (TME), significantly influence cancer development, primarily by promoting epithelial-mesenchymal transition (EMT). EMT endows cells with increased motility, invasiveness, and resistance to therapies, marking a pivotal juncture in progression. The review begins detailed exposition on origins TAMs their functional heterogeneity, providing foundational understanding TAM characteristics. Next, it delves into specific molecular mechanisms through which induce EMT, including cytokines, chemokines stromal cross-talking. Following this, explores TAM-induced features select types notable characteristics, highlighting recent insights impact Finally, concludes discussion potential therapeutic targets strategies aimed at mitigating infiltration disrupting signaling network, thereby underscoring emerging treatments combat TAM-mediated cancer. This comprehensive analysis reaffirms necessity for continued exploration TAMs’ regulatory roles within biology refine approaches improve patient outcomes.
Язык: Английский
Процитировано
3
Biomaterials, Год журнала: 2024, Номер 316, С. 123028 - 123028
Опубликована: Дек. 15, 2024
Язык: Английский
Процитировано
0