PPIC-labeled CAFs: Key players in neoadjuvant chemotherapy resistance for gastric cancer DOI Creative Commons

Honghao Yin,

Lili Sun,

Yuan Yuan

и другие.

Translational Oncology, Год журнала: 2024, Номер 48, С. 102080 - 102080

Опубликована: Авг. 7, 2024

Gastric cancer (GC) is the fourth leading cause of deaths, with advanced cases having a median survival less than one year. Neoadjuvant chemotherapy (NCT) vital but faces drug resistance issues, partly due to cancer-associated fibroblasts (CAFs). Yet, specific CAF subpopulations contributing are poorly understood.

Язык: Английский

A novel amino-pyrimidine inhibitor suppresses tumor growth via microtubule destabilization and Bmi-1 down-regulation DOI

Lijie Gao,

Jiawei Liu, Rui Zhang

и другие.

Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116783 - 116783

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Artificial intelligence in tumor drug resistance: Mechanisms and treatment prospects DOI Creative Commons
Jianyou Gu, Junfeng Zhang,

Silüe Zeng

и другие.

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Matrine Attenuates Streptococcus agalactiae Virulence by Suppressing Capsular Polysaccharide Synthesis and Host Adhesion Pathways DOI Creative Commons

Shijiao Guo,

Kaiming Wang, Hua Zhang

и другие.

Microorganisms, Год журнала: 2025, Номер 13(6), С. 1192 - 1192

Опубликована: Май 23, 2025

Streptococcus agalactiae (GBS) is a major pathogen causing mastitis in dairy cows while oxidative stress. Matrine an alkaloid compound extracted from the roots of Sophora flavescens, plant used traditional Chinese medicine. It possesses antioxidant, immunomodulatory, anti-inflammatory, and pro-apoptotic properties. The aim this study was to investigate regulatory effects matrine on virulence ATCC strain (ATCC13813) clinical GBS strains by transcriptome analysis qRT-PCR validation. results showed that ABC transporter, peptidoglycan biosynthesis, quorum-sensing pathways were significantly altered (4 mg/mL) (12 after treatment at MIC concentrations. Additionally, genes related invasion immune escape, including CylE, CAMP, ScpB, CpsA, expression adhesion factors, such as Bac, Lmb, PI2a, PI2b, downregulated (p < 0.05). Overall, these data suggest effectively inhibits GBS, thereby reducing evasion infection decreasing synthesis capsular polysaccharides host cell adhesion.

Язык: Английский

Процитировано

0
PPIC-labeled CAFs: Key players in neoadjuvant chemotherapy resistance for gastric cancer DOI Creative Commons

Honghao Yin,

Lili Sun,

Yuan Yuan

и другие.

Translational Oncology, Год журнала: 2024, Номер 48, С. 102080 - 102080

Опубликована: Авг. 7, 2024

Gastric cancer (GC) is the fourth leading cause of deaths, with advanced cases having a median survival less than one year. Neoadjuvant chemotherapy (NCT) vital but faces drug resistance issues, partly due to cancer-associated fibroblasts (CAFs). Yet, specific CAF subpopulations contributing are poorly understood.

Язык: Английский

Процитировано

0