Protein serine/threonine phosphatases in tumor microenvironment: a vital player and a promising therapeutic target DOI Creative Commons
Yiyang Liu, Xia Feng, Chang Zhu

и другие.

Theranostics, Год журнала: 2024, Номер 15(3), С. 1164 - 1184

Опубликована: Дек. 31, 2024

The tumor microenvironment (TME) is involved in cancer initiation and progression. With advances the TME field, numerous therapeutic approaches, such as antiangiogenic treatment immune checkpoint inhibitors, have been inspired developed. Nevertheless, sophisticated regulatory effects on biological balance of remain unclear. Decoding pathological features urgently needed to understand ecosystem develop novel antitumor treatments. Protein serine/threonine phosphatases (PSPs) are responsible for inverse protein phosphorylation processes. Aberrant expression dysfunction PSPs disturb cellular homeostasis, reprogram metabolic processes reshape landscape, thereby contributing Some implications, use targets, drawn attention researchers clinicians. To date, PSP inhibitors less satisfactory real-world practice. breakthroughs sequencing technologies, scientists can decipher investigations via multiomics higher resolution. These benefits provide an opportunity explore a more comprehensive manner inspire findings concerning TME. current review starts by introducing canonical knowledge PSPs, including their members, structures posttranslational modifications activities. We then summarize functions regulating homeostasis. In particular, we specified up-to-date roles modulating microenvironment, adopting hypoxia, reprogramming processes, responding extracellular matrix remodeling. Finally, introduce preclinical with translational value conclude clinical trials treatment.

Язык: Английский

Artificial intelligence in tumor drug resistance: Mechanisms and treatment prospects DOI Creative Commons
Jianyou Gu, Junfeng Zhang,

Silüe Zeng

и другие.

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
RNAa: Mechanisms, Therapeutic Potential, and Clinical Progress DOI Creative Commons

Yukang Qian,

Cody Liu,

Xuhui Zeng

и другие.

Molecular Therapy — Nucleic Acids, Год журнала: 2025, Номер 36(2), С. 102494 - 102494

Опубликована: Фев. 21, 2025

RNA activation (RNAa), a gene regulatory mechanism mediated by small activating RNAs (saRNAs) and microRNAs (miRNAs), has significant implications for therapeutic applications. Unlike interfering (siRNA), which is known silencing in interference (RNAi), synthetic saRNAs can stably upregulate target expression at the transcriptional level through assembly of RNA-induced (RITA) complex. Moreover, dual functionality endogenous miRNAs RNAa (hereafter referred to as mi-RNAa) reveals their complex role cellular processes disease pathology. Emerging studies suggest saRNAs' potential novel modality diseases such metabolic disorders, hearing loss, tumors, Alzheimer's. Notably, MTL-CEBPA, first saRNA drug candidate, shows promise hepatocellular carcinoma treatment, while RAG-01 being explored non-muscle-invasive bladder cancer, highlighting clinical advancements RNAa. This review synthesizes our current understanding mechanisms highlights recent study mi-RNAa development saRNAs.

Язык: Английский

Процитировано

1
Extracellular vesicles as nature's nano carriers in cancer therapy: insights toward preclinical studies and clinical applications DOI Creative Commons
Xiaotong Wu,

Yuhua Meng,

Zhimeng Yao

и другие.

Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107751 - 107751

Опубликована: Май 1, 2025

Extracellular vesicles (EVs), which are secreted by various cell types, hold significant potential for cancer therapy. However, there several challenges and difficulties that limit their application in clinical settings. This review, integrates the work of our team recent advancements this research field, discusses EV-based treatment strategies to guide application. The following discussed: 1) leveraging inherent properties EVs development treatments; 2) modifying using EV engineering methods improve drug loading delivery; 3) targeting key molecules tumor-derived (TDE) synthesis inhibit production; 4) clearing TDEs from tumor microenvironment. Additionally, on basis into vaccines bispecific antibodies, review elaborates enhance antitumor immunity via modifications can ability stability progress AI technology targeted delivery drugs. Although limited enhancing abilities, provides an in-depth discussion prior studies. Finally, summarizes use therapy highlights need be addressed.

Язык: Английский

Процитировано

1
Acquired resistance to tyrosine kinase targeted therapy: mechanism and tackling strategies DOI Creative Commons

Defa Wu,

Qian Sun, Hongjun Tang

и другие.

Drug Resistance Updates, Год журнала: 2024, Номер 78, С. 101176 - 101176

Опубликована: Ноя. 28, 2024

Язык: Английский

Процитировано

1
Protein serine/threonine phosphatases in tumor microenvironment: a vital player and a promising therapeutic target DOI Creative Commons
Yiyang Liu, Xia Feng, Chang Zhu

и другие.

Theranostics, Год журнала: 2024, Номер 15(3), С. 1164 - 1184

Опубликована: Дек. 31, 2024

The tumor microenvironment (TME) is involved in cancer initiation and progression. With advances the TME field, numerous therapeutic approaches, such as antiangiogenic treatment immune checkpoint inhibitors, have been inspired developed. Nevertheless, sophisticated regulatory effects on biological balance of remain unclear. Decoding pathological features urgently needed to understand ecosystem develop novel antitumor treatments. Protein serine/threonine phosphatases (PSPs) are responsible for inverse protein phosphorylation processes. Aberrant expression dysfunction PSPs disturb cellular homeostasis, reprogram metabolic processes reshape landscape, thereby contributing Some implications, use targets, drawn attention researchers clinicians. To date, PSP inhibitors less satisfactory real-world practice. breakthroughs sequencing technologies, scientists can decipher investigations via multiomics higher resolution. These benefits provide an opportunity explore a more comprehensive manner inspire findings concerning TME. current review starts by introducing canonical knowledge PSPs, including their members, structures posttranslational modifications activities. We then summarize functions regulating homeostasis. In particular, we specified up-to-date roles modulating microenvironment, adopting hypoxia, reprogramming processes, responding extracellular matrix remodeling. Finally, introduce preclinical with translational value conclude clinical trials treatment.

Язык: Английский

Процитировано

0