Hypervirulent Klebsiella pneumoniae (hvKp): Overview, Epidemiology, and Laboratory Detection
Pathogens and Immunity,
Год журнала:
2025,
Номер
10(1), С. 80 - 119
Опубликована: Янв. 24, 2025
Klebsiella
pneumoniae
(Kp)
is
a
Gram-negative
pathogen
responsible
for
both
hospital-
and
community-acquired
infections.
Kp
classified
into
2
distinct
pathotypes:
classical
K.
(cKp)
hypervirulent
(hvKp).
First
described
in
Taiwan
1986,
hvKp
are
highly
pathogenic
characterized
by
unique
phenotypic
genotypic
traits.
The
hypermucoviscous
(hmv)
phenotype,
generally
marked
overproduction
of
the
capsule,
often
associated
with
hvKp,
although
recent
studies
show
that
some
cKp
strains
may
also
have
this
characteristic.
Furthermore,
can
cause
severe
infections
healthy
people
been
metastatic
such
as
liver
abscess,
meningitis,
endophthalmitis.
HvKp
increasingly
being
reported
hospital-acquired
settings,
complicating
treatment
strategies.
In
particular,
while
historically
antibiotic-susceptible,
multidrug-resistant
(MDR)
emerged
pose
significant
public
health
threat.
combination
high
virulence
limited
antibiotic
options
demands
further
research
mechanisms
rapid
identification
methods.
This
review
discusses
epidemiology
their
factors,
highlighting
importance
non-phenotypic
tests,
including
next-generation
molecular
diagnostics,
early
detection
hvKp.
Язык: Английский
Prevalence of hypervirulent Klebsiella pneumoniae strains in COVID-19 patients with bacterial co-infections
Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 17, 2025
A
recent
alarming
report
from
the
World
Health
Organization
highlighted
rapid
global
spread
of
a
hypervirulent,
carbapenem-resistant
strain
Klebsiella
pneumoniae.
The
COVID-19
pandemic
frequently
led
to
bacterial
co-infections,
with
K.
pneumoniae
being
common
and
highly
pathogenic
agent.
This
study
aimed
assess
KP
characteristics
via
whole-genome
sequencing
clarify
its
molecular
epidemiology
guide
standardized
clinical
treatment.
Our
retrospective
analysis
data
patients
admitted
our
hospital
between
7
December
2022,
2
January
2023-following
China's
policies
changes,
which
significant
influx
patients-identified
17
isolates
sputum
samples
co-infections.
These
underwent
for
ST
typing,
virulence
gene
annotation,
plasmid
profiling,
antimicrobial
susceptibility
testing.
Of
isolates,
52.9%
were
hypermucoviscous.
Whole
genome
identified
eight
sequence
types
(STs),
ST23/KL1
most
prevalent
at
35.3%.
Virulence
genes
present
in
94.1%
strains,
including
Yersiniabactin
(70.6%),
Aerobactin
(82.3%),
Salmochelin
(88.2%).
Plasmid
revealed
IncHI1B/FIBk
or
IncFIBk
types.
All
sensitive
antibiotics,
except
blaSHV
resistance.
had
median
age
71
years
comorbidities,
such
as
hypertension
(64.7%)
diabetes
(41.2%).
profiles
indicate
that
strains
co-infecting
are
common,
high-virulence
Asia-Pacific
region.
findings
suggest
may
contribute
hypervirulent
potentially
informing
ongoing
WHO
epidemic
alert.
Язык: Английский
Genomically defined hypervirulent Klebsiella pneumoniae contributed to early-onset increased mortality
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 1, 2025
The
presence
of
all
five
the
virulence-associated
genes
iucA,
iroB,
peg-344,
rmpA,
and
rmpA2
is
presently
most
accurate
genomic
means
for
predicting
hypervirulent
Klebsiella
pneumoniae
(hvKp-p).
With
this
longitudinal
cohort
study,
we
firstly
provide
novel
insights
into
clinical
characteristics
hvKp-p
in
high-risk
regions.
Through
propensity
score
matching,
show
that
less
likely
to
acquire
antimicrobial
resistance
but
develops
more
severe
disease
result
increased
mortality.
HvKp-p
are
predominantly
isolated
from
hospital
settings
caused
pneumonia
majority
cases.
ST23
KL1
common
types
cohort.
Community-acquired
healthcare-associated
infections
also
identified
as
independent
risk
factors
hvKp-p.
This
definition,
albeit
imperfect,
offers
a
practical
efficient
alternative
murine
models,
allowing
early
identification
timely
intervention
settings.
Using
an
biomarker
signature
identify
(hvKp-p),
authors
perform
study
insight
Язык: Английский
Prediction of fatal outcome in patients with pneumonia caused by carbapenem-resistant Klebsiella pneumoniae
Medical and Biological Problems of Life Activity,
Год журнала:
2025,
Номер
1, С. 89 - 94
Опубликована: Апрель 27, 2025
Pneumonia
caused
by
carbapenem-resistant
K.
pneumoniae
often
has
a
severe
course
and
significant
risk
of
unfavorable
outcome.
Various
scales
indices
have
been
proposed
for
timely
assessment
the
patient's
condition
detection
high
For
attending
physician,
ease
use
prognostic
accuracy
index
used
in
are
important.
The
aim
study
was
to
evaluate
diagnostic
significance
clinical
laboratory
parameters
predicting
fatal
outcome
patients
with
pneumonia
pneumoniae.
A
total
71
cases
multiple
extreme
drug
resistance
were
retrospectively
analyzed.
Two
groups
formed
depending
on
outcome:
group
1
–
41
discharged
from
hospital
upon
completion
treatment;
2
30
structure
concomitant
diseases,
body
mass
(BMI),
blood
saturation
(SpO
),
hemogram
parameters,
C-reactive
protein
(CRP)
It
found
that
characterized
higher
leukocyte
counts,
neutrophils
hemogram,
neutrophil/lymphocyte
ratio
(NLR),
CRP,
BMI;
lower
lymphocyte
SpO2.
most
indicators
an
lymphocytes,
neutrophils,
NLR,
BMI.
To
predict
death,
we
(BMI*NLR)/SpO
.
ROC
analysis
performed:
AUC
0,99
(0,93–1,00),
test
sensitivity
100,0
%,
specificity
97,6
%
at
cutoff
point
>
1,53,
Youden
0,98.
Diagnostic
value
(at
threshold
1,53):
is
95,1
positive
predictive
93,8
negative
97,2
%.
level
1,53)
may
be
preferable
pneumoniae,
due
its
(100
%)
(97,6
%),
as
well
use.
Язык: Английский
Overexpression of bla SHV-12 caused by tandem amplification contributed to ceftazidime/avibactam resistance in hypervirulent and carbapenem-resistant Klebsiella pneumoniae
Emerging Microbes & Infections,
Год журнала:
2024,
Номер
13(1)
Опубликована: Ноя. 5, 2024
We
identified
a
novel
ceftazidime/avibactam
(CAZ/AVI)
resistance
mechanism
in
endemic
sequence
type
11
hypervirulent
and
carbapenem-resistant
Klebsiella
pneumoniae
isolated
from
patient
who
had
not
been
exposed
CAZ/AVI.
Overexpression
of
blaSHV-12
caused
by
tandem
gene
amplification
contributed
to
CAZ/AVI
instead
the
carriage
blaKPC-2.
Enhanced
genomic
surveillance
is
essential
identify
emerging
variants.
Язык: Английский