Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications
Molecular Cancer,
Год журнала:
2025,
Номер
24(1)
Опубликована: Март 8, 2025
Epigenomic
modifications—such
as
DNA
methylation,
histone
acetylation,
and
methylation—and
their
implications
in
tumorigenesis,
progression,
treatment
have
emerged
a
pivotal
field
cancer
research.
Tumors
undergo
metabolic
reprogramming
to
sustain
proliferation
metastasis
nutrient-deficient
conditions,
while
suppressing
anti-tumor
immunity
the
tumor
microenvironment
(TME).
Concurrently,
immune
cells
within
immunosuppressive
TME
adaptations,
leading
alterations
function.
The
complicated
interplay
between
metabolites
epigenomic
modulation
has
spotlighted
significance
of
regulation
immunometabolism.
In
this
review,
characteristics
modification
associated
with
tumors
are
systematically
summarized
alongside
regulatory
roles
Classical
emerging
approaches
delineated
broaden
boundaries
research
on
crosstalk
immunometabolism
epigenomics.
Furthermore,
we
discuss
potential
therapeutic
strategies
that
target
modulate
modifications,
highlighting
burgeoning
synergy
therapies
immunotherapy
promising
avenue
for
treatment.
Язык: Английский
LncRNA MIR17HG drives cisplatin resistance partially via miR-138-5p/AKAP9 axis in cholangiocarcinoma
Scandinavian Journal of Gastroenterology,
Год журнала:
2025,
Номер
unknown, С. 1 - 13
Опубликована: Янв. 8, 2025
Objectives
This
study
aims
to
discover
the
role
of
lncRNA
MIR17HG,
referred
as
in
cisplatin
resistance
for
cholangiocarcinoma
(CCA).
Язык: Английский
Artificial intelligence in tumor drug resistance: Mechanisms and treatment prospects
Опубликована: Фев. 1, 2025
Язык: Английский
NAD+/SIRT1 pathway regulates glycolysis to promote oxaliplatin resistance in colorectal cancer
World Journal of Gastroenterology,
Год журнала:
2025,
Номер
31(11)
Опубликована: Март 12, 2025
BACKGROUND
Glycolysis
provides
growth
advantages
and
leads
to
drug
resistance
in
colorectal
cancer
(CRC)
cells.
SIRT1,
an
NAD+-dependent
deacetylase,
regulates
various
cellular
processes,
its
upregulation
results
antitumor
effects.
This
study
investigated
the
role
of
SIRT1
metabolic
reprogramming
oxaliplatin
CRC
AIM
To
investigate
overcoming
METHODS
We
performed
transcriptome
sequencing
human
parental
cells
oxaliplatin-resistant
identify
differentially
expressed
genes.
Key
regulators
were
identified
via
LINCS
database.
NAD+
levels
measured
by
flow
cytometry,
effects
on
sensitivity
assessed
MTS
assays,
colony
formation
xenograft
models.
Glycolytic
function
was
using
Western
blot
Seahorse
assays.
RESULTS
Salermide,
a
inhibitor,
as
candidate
compound
that
enhances
resistance.
In
cells,
downregulated,
whereas
γH2AX
PARP
upregulated.
activation
led
depletion
inhibition,
which
reversed
inhibitor
treatment.
The
increase
expression
overcame
resistance,
while
inhibition
increased
glycolysis,
inhibited
glycolysis
resistant
characterized
reduced
glycolytic
enzymes
PKM2
LDHA,
well
decreased
extracellular
acidification
rate.
shikonin
induced
inhibition.
CONCLUSION
is
due
activation,
turn
increases
glycolysis.
Restoring
reverses
offering
promising
therapeutic
strategy
overcome
Язык: Английский
FADS2 inhibits colorectal cancer cell proliferation by regulating ferroptosis through SLC7A11/GPX4
Molecular Biology Reports,
Год журнала:
2025,
Номер
52(1)
Опубликована: Апрель 15, 2025
Язык: Английский
A Novel Platinum(IV) Prodrug, Gramine-Pt(IV) Enhances Chemoimmunotherapy by activating cGAS-STING and modulating TGF-β-MHC-I axis
Drug Resistance Updates,
Год журнала:
2025,
Номер
81, С. 101252 - 101252
Опубликована: Май 11, 2025
Язык: Английский
A platinum(iv)–crocetin nanoplatform with intracellular morphological transformation for enhanced colorectal cancer therapy
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Pt(
iv
)–Cro
NPs
demonstrate
concentration-dependent
self-assembly
and
intracellular
transformation,
enhancing
cisplatin's
antitumor
efficacy
against
colorectal
cancer
through
boosted
cytotoxicity,
mitochondrial
damage,
ROS
generation.
Язык: Английский
Synergistic chemotherapy and immunomodulatory effects of Quercetin in cancer: a review
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Май 26, 2025
Cancer
is
a
significant
public
health
problem
worldwide,
and
its
morbidity
mortality
are
challenging
to
improve,
which
an
important
obstacle
prolonging
life
expectancy.
Cytotoxic
drugs
have
been
used
in
anti-cancer
therapy
since
the
1940s.
They
play
role
tumor
therapy.
However,
drug
resistance
systemic
toxicity
often
limit
application.
Combination
or
synergistic
chemotherapy
can
promote
therapeutic
effects
reduce
toxicity.
Quercetin
(QUE)
natural
flavonoid
widely
found
fruits
vegetables.
It
has
anti-cancer,
anti-inflammatory,
antioxidant,
neuroprotective
properties.
An
increasing
number
of
studies
that
combination
QUE
chemosensitization
effect.
To
certain
extent,
it
inhibit
side
chemotherapeutic
drugs,
such
as
nephrotoxicity,
cardiotoxicity,
reproductive
toxicity,
neurotoxicity,
attracted
great
attention.
The
immune
system
plays
development.
Notably,
several
revealed
immunomodulatory
by
promoting
differentiation
cells
inhibiting
checkpoint
expression.
In
conclusion,
current
emphasized
potential
chemosensitization,
reduction
toxic
effects,
enhancement
response.
more
preclinical
clinical
cohort
needed
determine
QUE’s
efficacy,
mechanism,
optimal
formulation,
long-term
effects.
Язык: Английский
Emerging role of small RNAs in inflammatory bowel disease and associated colorectal cancer (Review)
International Journal of Molecular Medicine,
Год журнала:
2024,
Номер
55(2)
Опубликована: Дек. 18, 2024
Inflammatory
bowel
diseases
(IBDs),
which
encompasses
Crohn's
disease
and
ulcerative
colitis,
is
a
chronic
inflammatory
condition
associated
with
an
increased
risk
of
colorectal
cancer
(CRC).
Small
RNAs
have
been
linked
to
various
illnesses,
including
IBD
CRC.
These
small
also
serve
as
potential
biomarkers
for
these
diseases,
offering
cutting‑edge
approach
investigating
possible
treatments.
To
date,
treatments
involving
oral
nucleic
acid
usage
are
still
unachievable
due
the
instability
medications
in
gastrointestinal
tract
(GIT),
their
lack
ability
effectively
target
tissues
notable
adverse
effects.
However,
nanoparticle
or
exosome
delivery
systems
by
overcoming
GIT,
resulting
effective
outcome.
In
present
review,
biogenesis
(tRNA‑derived
RNA,
microRNA,
nucleolar
RNA
p‑element‑induced
wimpy
testis‑interacting
RNA),
roles
pathogenesis
CRC
well
application
diagnostic
prognostic
discussed.
Язык: Английский