Medical Oncology, Год журнала: 2024, Номер 42(1)
Опубликована: Дек. 13, 2024
Язык: Английский
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 25, 2025
Язык: Английский
Процитировано
1
Antioxidants, Год журнала: 2025, Номер 14(1), С. 115 - 115
Опубликована: Янв. 20, 2025
The role of mitochondria as the electric engine cells is well established. Over past two decades, accumulating evidence has pointed out that, despite presence a highly active glycolytic pathway (Warburg effect), functional and even upregulated mitochondrial respiration occurs in cancer to meet need high energy biosynthetic demand sustain their anabolic growth. Mitochondria are also primary source intracellular ROS. Cancer maintain moderate levels ROS promote tumorigenesis, metastasis, drug resistance; indeed, once cytotoxicity threshold exceeded, trigger oxidative damage, ultimately leading cell death. Based on this, metabolic functions generation considered attractive targets synthetic natural anticancer compounds. Tocotrienols (TTs), specifically δ- γ-TT isoforms, vitamin E-derived biomolecules widely shown possess striking properties since they regulate several molecular pathways. Herein, we provide for first time an overview reprogramming redox homeostasis perturbation occurring cells, highlighting involvement TTs. This sheds light use these compounds promising preventive or therapeutic approach novel strategies.
Язык: Английский
Процитировано
0
Pathology - Research and Practice, Год журнала: 2025, Номер 267, С. 155837 - 155837
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Фев. 18, 2025
Gastric cancer (GC) is a prevalent malignant tumor that originates from the epithelial cells of gastric mucosa, predominantly in form adenocarcinoma. Extensive research has confirmed significant role autophagy initiation, progression, and chemoresistance GC. The potential traditional Chinese medicine (TCM) to exert anti-tumor effects by modulating been demonstrated, particularly context GC prevention treatment. Natural products (NPs) have great therapeutic treatment targeting autophagy-related genes signaling pathways intervene biological behaviors such as proliferation, metastasis, invasion death. This article describes molecular mechanisms key markers autophagy, involved GC-associated (PI3K/AKT/mTOR, AMPK, MAPK, p53), summarizes mechanism Helicobacter pylori infection GC, how interacts with apoptotic iron-death processes wide-ranging influences these factors play process. Finally, this paper systematically natural compounds terpenoids, polyphenols, alkaloids, saponins, polysaccharides modulate targets for evaluates toxic NPs, providing more compelling rationale direction therapy.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141235 - 141235
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
0
Journal of Hematology & Oncology, Год журнала: 2025, Номер 18(1)
Опубликована: Март 18, 2025
In the domain of addressing cancer resistance, challenges such as limited effectiveness and treatment resistance remain persistent. Hypoxia is a key feature solid tumors strongly associated with poor prognosis in patients. Another significant portion development acquired drug attributed to tumor stemness. Cancer stem cells (CSCs), small cell subset self-renewal proliferative abilities, are crucial for initiation, metastasis, intra-tumoral heterogeneity. Studies have shown association between hypoxia CSCs context resistance. Recent studies reveal strong link stemness, which together promote survival progression during treatment. This review elucidates interplay CSCs, well their correlation therapeutic drugs. Targeting pivotal genes stemness holds promise novel therapeutics combat
Язык: Английский
Процитировано
0
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Март 19, 2025
The immunotherapy targeting tumor immune escape mechanisms has become a critical strategy in anticancer treatment; however, the challenge of resistance remains significant. Autophagy, cellular response to various stressors, involves degradation damaged proteins and organelles via lysosomal pathways, maintaining homeostasis. This process not only supports cell survival but also profoundly impacts efficacy cancer immunotherapies. modulation autophagy cells or exerts dual effects on immunotherapy. However, mechanistic details how influences system therapy remain inadequately understood. Given this complexity, deeper understanding role tumor-immune landscape could reveal novel therapeutic avenues. By manipulating appropriately, it may be possible overcome enhance effectiveness immunotherapeutic strategies. article summarizes immunity, its relationship with immunotherapy, potential benefits strengthen antitumor responses optimize outcomes
Язык: Английский
Процитировано
0
Pathology - Research and Practice, Год журнала: 2025, Номер unknown, С. 155928 - 155928
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Pathology - Research and Practice, Год журнала: 2025, Номер unknown, С. 155934 - 155934
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Cell Death Discovery, Год журнала: 2025, Номер 11(1)
Опубликована: Апрель 5, 2025
Abstract Gastric cancer, marked by its high incidence and poor prognosis, demands the urgent development of novel effective treatment strategies, especially for patients ineligible surgery or those who have had limited success with chemotherapy, radiotherapy targeted therapies. Recently, antibody-drug conjugates (ADCs) become a key area investigation due to their specificity potent antitumor effects. These therapies combine monoclonal antibodies, designed bind tumor-specific antigens, cytotoxic agents that selectively target destroy malignant cells. ADCs generated significant interest in clinical trials as promising approach improve both efficacy patient outcomes gastric cancer. However, application is not without challenges limitations must be addressed. This review discusses recent progress use cancer treatment.
Язык: Английский
Процитировано
0