Long COVID, the Brain, Nerves, and Cognitive Function

Neurology International, Год журнала: 2023, Номер 15(3), С. 821 - 841

Опубликована: Июль 6, 2023

SARS-CoV-2, a single-stranded RNA coronavirus, causes an illness known as coronavirus disease 2019 (COVID-19). Long-term complications are increasing issue in patients who have been infected with COVID-19 and may be result of viral-associated systemic central nervous system inflammation or arise from virus-induced hypercoagulable state. incite changes brain function wide range lingering symptoms. Patients often experience fatigue note fog, sensorimotor symptoms, sleep disturbances. Prolonged neurological neuropsychiatric symptoms prevalent can interfere substantially everyday life, leading to massive public health concern. The mechanistic pathways by which SARS-CoV-2 infection sequelae important subject ongoing research. Inflammation- induced blood-brain barrier permeability viral neuro-invasion direct nerve damage involved. Though the mechanisms uncertain, resulting documented numerous patient reports studies. This review examines constellation spectrum seen long COVID incorporates information on prevalence these contributing factors, typical course. Although treatment options generally lacking, potential therapeutic approaches for alleviating improving quality life explored.

Язык: Английский

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Vascular Endothelial Growth Factor as Potential Biomarker for COVID-19 Severity

Journal of Intensive Care Medicine, Год журнала: 2023, Номер 38(12), С. 1165 - 1173

Опубликована: Июль 13, 2023

Introduction COVID-19 is characterized by immunological responses to viral replication and coherent with endothelitis, microvascular disturbance of lung vasculature coagulopathy. Vascular Endothelial Growth Factor (VEGF) a proangiogenic mediator regulating endothelial changes. It induced proinflammatory signaling hypoxia. We sought determine whether VEGF levels differ between SARS-CoV-2-positive patients different disease severity might be useful in risk stratification. Methods After retrospective screening all treated Unfallkrankenhaus Berlin 2020, we included those documented measurement. extracted laboratory values clinical parameters. An exploratory data analysis was performed detect possible relations level features. Results 167 which 139 suffered from COVID-19. Seventy-one the had intensive care unit (ICU), exhibited higher than being admitted normal wards (535 vs 279 pg/L, P < .001). APACHE-2 (Acute Physiology And Chronic Health Evaluation Score) correlated mortality high showed concentrations on admission (456 875 p = 0.006). Receiver operating characteristic analytic revealed that occurrence organ dysfunctions like acute respiratory distress syndrome (ARDS), shock, or kidney injury could predicted VEGF. significantly who later died compared survivors (637 389 pg/mL, 0.041) same accuracy as established markers. In our cohort, association above 277 pg/L ARDS confirmed logistic regression adjusting for confounding factors (odds ratio 3.1, 95% confidence interval: 1.34-7.7). Discussion Even though there are several limitations this study it can contribute prediction necessity ICU, ARDS, shock. Its use stratification potential pathogenetic involvement should further investigated.

Язык: Английский

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Post-COVID cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction: national prospective study

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Янв. 5, 2024

The spectrum, pathophysiology, and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention treatment strategies. We report the one-year cognitive, serum biomarker, neuroimaging findings from a prospective, national longitudinal study cognition in 351 COVID-19 patients who had required hospitalisation, compared 2,927 normative matched controls. Cognitive were global associated with elevated brain injury markers reduced anterior cingulate cortex volume one year after admission. severity initial infective insult, post-acute psychiatric symptoms, history encephalopathy greatest deficits. There was strong concordance between subjective objective Treatment corticosteroids during acute phase appeared protective against Together, these support hypothesis that moderate severe is immune-mediated, should guide development therapeutic

Язык: Английский

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Effect of the new coronavirus infection COVID-19 on the course and prognosis of tuberculous meningoencephalitis in HIV-infected patients

S S Korsakov Journal of Neurology and Psychiatry, Год журнала: 2025, Номер 125(3), С. 33 - 33

Опубликована: Апрель 8, 2025

Objective. To study the effect of new coronavirus infection COVID-19 on course and prognosis tuberculous meningoencephalitis in HIV-infected patients. Material methods. The main group included 46 patients with human immunodeficiency virus (HIV) who were infected a infection. comparison 52 HIV had no history All underwent laboratory tests for infectious diseases (including analysis cerebrospinal fluid (CSF)), parameters hemostasis system, CT lungs brain as part an inpatient examination. Results. obtained data showed that aggravates meningoencephalitis, increases mortality, affects mechanisms thanatogenesis, significantly increasing frequency multi-organ failure compared to group. In infection, according results computed tomography brain, hydrocephalus was recorded more often, mycobacterium DNA reliably detected CSF using polymerase chain reaction, syndrome impaired consciousness at presentation common, period from admission death reduced. Conclusion. New obtained, suggesting correlations between combination manifestations HIV, acute toxic-infectious encephalopathy syndrome, well role DIC which is common this category

Язык: Английский

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Neuropsychiatric Manifestations of Long COVID-19: A Narrative Review of Clinical Aspects and Therapeutic Approaches

Life, Год журнала: 2025, Номер 15(3), С. 439 - 439

Опубликована: Март 11, 2025

The COVID-19 (C-19) pandemic has highlighted the significance of understanding long-term effects this disease on quality life those infected. Long (L-C19) presents as persistent symptoms that continue beyond main illness period, usually lasting weeks to years. One lesser-known but significant aspects L-C19 is its impact neuropsychiatric manifestations, which can have a profound effect an individual’s life. Research shows creates issues such mental fog, emotional problems, and brain symptoms, along with sleep changes, extreme fatigue, severe head pain, tremors seizures, pain in nerves. People cognitive problems plus fatigue mood disorders experience great difficulty handling everyday activities, personal hygiene, social interactions. Neuropsychiatric make people withdraw from activity hurt relationships, thus causing feelings loneliness. unpredictable state generates heavy psychological pressure through suffering, including depression anxiety. changes impairment, swings it hard for work or study effectively, decreases their output at school lowers job contentment. purpose narrative review summarize clinical data present literature regarding manifestations L-C19, identify current methods diagnosis treatment lead correct management condition, highlight these patients’

Язык: Английский

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Characteristics of suicidal emergency room patients before and during the COVID‐19 pandemic in Japan

Neuropsychopharmacology Reports, Год журнала: 2023, Номер 43(2), С. 255 - 263

Опубликована: Апрель 25, 2023

Owing to the stress caused by behavioral restrictions and lifestyle changes during COVID-19 pandemic, suicide rates have increased in Japan, especially among young people. This study aimed identify differences characteristics of patients hospitalized for attempts emergency room, requiring inpatient care before pandemic over 2 years.

Язык: Английский

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Discovery of Delirium Biomarkers through Minimally Invasive Serum Molecular Fingerprinting

Metabolites, Год журнала: 2024, Номер 14(6), С. 301 - 301

Опубликована: Май 26, 2024

Delirium presents a significant clinical challenge, primarily due to its profound impact on patient outcomes and the limitations of current diagnostic methods, which are largely subjective. During COVID-19 pandemic, this challenge was intensified as frequency delirium assessments decreased in Intensive Care Units (ICUs), even prevalence among critically ill patients increased. The present study evaluated how serum molecular fingerprint, acquired by Fourier-Transform InfraRed (FTIR) spectroscopy, can enable development predictive models for delirium. A preliminary univariate analysis FTIR spectra indicated significantly different bands between 26 ICU with without, all whom were admitted COVID-19. However, these resulted poorly performing Naïve-Bayes model. Considering use Fast-Correlation-Based Filter feature selection, it possible define new set spectral wider coverage functional groups. These ensured an excellent model, AUC, sensitivity, specificity exceeding 0.92. bands, through minimally invasive obtained rapidly, economically, high-throughput mode, therefore offer potential managing patients.

Язык: Английский

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COVID-19-associated encephalopathy: connection between neuroinflammation and microbiota-gut-brain axis

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Май 28, 2024

While neurological complications of COVID-19, such as encephalopathy, are relatively rare, their potential significant impact on long-term morbidity is substantial, especially given the large number infected patients. Two proposed hypotheses for pathogenesis this condition hypoxia and uncontrolled release proinflammatory cytokines. The gut microbiota plays an important role in regulating immune homeostasis overall health, including its effects brain health through various pathways collectively termed gut–brain axis. Recent studies have shown that COVID-19 patients exhibit dysbiosis, but how dysbiosis can affect inflammation central nervous system (CNS) remains unclear. In context, we discuss could contribute to neuroinflammation provide recent data features

Язык: Английский

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COVID-19: Unveiling the Neuropsychiatric Maze—From Acute to Long-Term Manifestations

Biomedicines, Год журнала: 2024, Номер 12(6), С. 1147 - 1147

Опубликована: Май 22, 2024

The SARS-CoV-2 virus has spread rapidly despite implementing strategies to reduce its transmission. disease caused by this been associated with a diverse range of symptoms, including common neurological manifestations such as dysgeusia, anosmia, and myalgias. Additionally, numerous cases severe complications have reported, encephalitis, stroke, seizures, Guillain–Barré syndrome, among others. Given the high prevalence in disease, objective review is analyze mechanisms which can affect nervous system, from direct invasion aberrant activation immune system other involved neuropsychiatric manifestations, gain better understanding thus facilitate search for effective therapeutic strategies.

Язык: Английский

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Exploring the Association between Delirium and Malnutrition in COVID-19 Survivors: A Geriatric Perspective

Nutrients, Год журнала: 2023, Номер 15(22), С. 4727 - 4727

Опубликована: Ноя. 9, 2023

Older individuals face an elevated risk of developing geriatric syndromes when confronted with acute stressors like COVID-19. We assessed the connection between in-hospital delirium, malnutrition, and frailty in a cohort COVID-19 survivors. Patients aged ≥65, hospitalized tertiary hospital Milan for SARS-CoV-2 pneumonia, were enrolled screened delirium 4 ‘A’s Test (4AT) performed twice daily (morning evening) during stay. Malnutrition was malnutrition universal screening tool (MUST) at admission mini-nutritional assessment short-form (MNA-SF) one month after discharge. Frailty computed index Fifty patients (median age 78.5, 56% male) enrolled. At admission, 10% malnourished. The 13 (26%) who developed frailer (7 vs. 4), experienced higher mortality (5 3), more malnourished discharge (3 6 28 without presented follow up). 4AT scores correlated MNA-SF (r = −0.55, p 0.006) 0.35, 0.001). also MUST 0.3, 0.04), −0.42, 0.02), hospitalization length 0.44, Delirium, are Screening these should be incorporated routine clinical practice.

Язык: Английский

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