Simultaneous Detection of Hydrogen Sulfide and Peroxynitrite Dysregulation with a Sequentially Activated Fluorescent Probe in Ulcerative Colitis Disease DOI
Yiliang Chen,

Jiawei Bao,

Qi Wang

и другие.

Analytical Chemistry, Год журнала: 2024, Номер 97(1), С. 721 - 730

Опубликована: Дек. 30, 2024

Ulcerative colitis (UC), often referred to as "green cancer", is a chronic inflammatory bowel disease with an unclear etiology, closely associated the imbalance of hydrogen sulfide (H2S) and peroxynitrite (ONOO-). H2S exhibits anti-inflammatory effects at physiological levels, but excessive concentrations can compromise intestinal barrier, while ONOO- aggravates inflammation. To facilitate molecular-level monitoring these compounds in UC, we developed novel fluorescent probe, BCH, capable simultaneously detecting via distinct channels cascade mode. BCH features rapid response times (H2S: 6 min; ONOO-: 5 min) well-separated emission peaks (120 nm), minimizing spectral overlap. The probe demonstrates high selectivity good detection linearity for (0-500 μM) (0-100 μM), limits 1.6 μM 0.05 ONOO-. has been successfully applied imaging living cells zebrafish, enabling sensitive their fluctuations UC mouse model. These findings indicate that highly promising studying roles assessing biological functions.

Язык: Английский

Hydrogen Sulfide detection: Recent advancement and future perspectives towards Fluorescence as a Versatile Biophysical Method DOI
Vivek Pandey, Tejasvi Pandey

Nitric Oxide, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
A novel liver-targeted and highly selective fluorescent probe for hepatic hydrogen sulfide detection in the diagnosis of drug-induced liver injury DOI
Yalin Li, Bing Liao, Qunyou Tan

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117640 - 117640

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Recent advances in photoelectrochemical detection of hydrogen sulfide DOI Creative Commons
Fang Chen, Xiuhua Wei, Yuanqiang Hao

и другие.

International Journal of Electrochemical Science, Год журнала: 2025, Номер unknown, С. 101046 - 101046

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Simultaneous Detection of Hydrogen Sulfide and Peroxynitrite Dysregulation with a Sequentially Activated Fluorescent Probe in Ulcerative Colitis Disease DOI
Yiliang Chen,

Jiawei Bao,

Qi Wang

и другие.

Analytical Chemistry, Год журнала: 2024, Номер 97(1), С. 721 - 730

Опубликована: Дек. 30, 2024

Ulcerative colitis (UC), often referred to as "green cancer", is a chronic inflammatory bowel disease with an unclear etiology, closely associated the imbalance of hydrogen sulfide (H2S) and peroxynitrite (ONOO-). H2S exhibits anti-inflammatory effects at physiological levels, but excessive concentrations can compromise intestinal barrier, while ONOO- aggravates inflammation. To facilitate molecular-level monitoring these compounds in UC, we developed novel fluorescent probe, BCH, capable simultaneously detecting via distinct channels cascade mode. BCH features rapid response times (H2S: 6 min; ONOO-: 5 min) well-separated emission peaks (120 nm), minimizing spectral overlap. The probe demonstrates high selectivity good detection linearity for (0-500 μM) (0-100 μM), limits 1.6 μM 0.05 ONOO-. has been successfully applied imaging living cells zebrafish, enabling sensitive their fluctuations UC mouse model. These findings indicate that highly promising studying roles assessing biological functions.

Язык: Английский

Процитировано

0