Опубликована: Ноя. 14, 2024
Язык: Английский
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
We have developed self-assembled nanoparticles (BODIPY 4 -PEG NPs) that exhibit excellent imaging performance and photothermal conversion efficiency.
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 19, 2024
Over the years, oral and maxillofacial injuries, mainly caries, pulpitis, bone defects, cancer, often involve a variety of organs tissues, resulting in structural dysfunction, adverse effects on facial appearance, not only affecting people's chewing, swallowing other physiological functions, but also to physical mental health burden. As type carbon-based nanomaterial, carbon dots (CDs) have been widely used diagnosis treatment diseases due its excellent optical properties, good biocompatibility low toxicity. In addition, surface functionalization or passivation CDs can change properties CDs, such as water solubility chemiluminescence, broaden biomedical potential CDs. this review, latest research progress modified hard tissue regeneration, tumor treatment, antibacterial activity, dentin pulp complex teeth whitening, wound healing, drug release, fluorescence tracer bioimaging were reviewed. we discussed problems future direction development.
Язык: Английский
Процитировано
2
Materials Horizons, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Alzheimer's disease (AD) is a chronic, progressive neurodegenerative disorder marked by permanent impairment of brain function across the whole brain. This condition results in deterioration cognitive patients and frequently associated with psychological symptoms such as agitation anxiety, imposing significant burden on both their families. Nanomaterials possess numerous distinctive physical chemical features that render them extensively utilized. In biomedical domain, nanomaterials can be utilized for prevention therapy, including medication delivery systems, biosensors, tissue engineering. article explores etiology potential molecular processes AD, well application carbon-based diagnosis treatment AD. Some are carbon quantum dots, nanotubes, graphene, among others. These materials physicochemical highly promising applications biosensing, drug delivery, neuroprotection, photothermal treatment. addition, this review explored various therapeutic approaches AD terms reducing inflammation, preventing oxidative damage, inhibiting Aβ aggregation. The advent nanotechnology has facilitated development novel disease. strategies provide early diagnosis, effective intervention neuroprotection
Язык: Английский
Процитировано
2
BMC Chemistry, Год журнала: 2024, Номер 18(1)
Опубликована: Окт. 24, 2024
Abstract New Series of N -Manniche bases 3,4 (a-c) and 5,6 (a-b) were synthesized through the reaction benzaldehyde amine with 3-methyl-4-(aryldiazenyl)-1H-pyrazol-5-ol derivatives 2(a-c), they fully characterized by FT-IR, ( 1 H, 13 C) NMR data in addition to their mass spectra. The Structural Activity Relationship target compounds examined for cytotoxicity. Some newly showed promising antiproliferation properties when tested against HepG2 cancer cells. Compounds 4a, 5a, 6b potent cytotoxicity IC 50 values 4.4, 3.46 2.52 µM compared Sorafenib (IC = 2.051 µM) Roscovitine 4.18 µM). Furthermore, safe THLE2 cells higher values. Compound exhibited dual VEGFR2/CDK-2 inhibition activities; it had an value 0.2 μM VEGFR2 93.2%, 0.458 CDK-2 88.7%. In comparison untreated control group (0.95%), 5a (38.32%) (42.9%) considerably increased cell population total apoptosis. addition, arrested at G0-G1 S phases, respectively. Molecular docking experiments confirmed virtual binding mechanism most active drugs, which found have good affinities both receptor sites.
Язык: Английский
Процитировано
0
Farabi Tıp Dergisi, Год журнала: 2024, Номер unknown
Опубликована: Дек. 10, 2024
Photodynamic therapy (PDT) is known as a method in which photosensitizers produce reactive oxygen species the presence of light and oxygen, leading to cell death. In this paper, DNA interaction properties bis[4-({8)-[3-(trimethylamino)phenoxy]octyl}oxy)] substituted silicon (IV) phthalocyanine (GsB-SiPc) were examined using UV-Vis spectrophometer agarose gel electrophoresis techniques. Afterwards, cytotoxic/phototoxic effects GsB-SiPc 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays on A549 cells. The results showed that bound ct-DNA via groove binding mode. nuclease/photonuclease experiments, had low nuclease activity dark but it high photonuclease light, depending compound concentration dose. addition, demonstrated remarkable phototoxicity toward human lung adenocarcinoma (A549) line at 50 100 µM light. vitro data revealed potential photodynamic agent for treatment cancer. These findings need be supported by further studies.
Язык: Английский
Процитировано
0
Опубликована: Ноя. 14, 2024
Язык: Английский
Процитировано
0