Rhamnolipid-Modified PHB–Ectoine Nanoparticles for Multifunctional Skin Protection Against UVB, Irritation, and Bacteria DOI Creative Commons
Alma Tyara Simbara, Fera Faridatul Habibah, Rukman Hertadi

и другие.

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Rhamnolipid, poly(R)-3-hydroxybutyrate (PHB), and ectoine are sustainable compounds produced by specific bacteria known for their protective benefits, including promoting skin health in applications, such as facial wash, sunscreens, moisturizers. These have been extensively studied due to unique physicochemical properties biocompatibility. Leveraging these beneficial properties, this study aimed create a multifunctional formulation synthesizing nanoparticles from PHB ectoine, which acknowledged anti-ultraviolet B (UVB) anti-irritation properties. The covalent bonding of was achieved using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), the were through centrifugation. synthesized nanoparticle (PHB–ectoine NPs) physicochemically characterized tested anti-UVB vitro. characterization revealed homogeneous spherical shape with distinct layered structure, primarily composed carbon oxygen. PHB–ectoine NPs measured 527 ± 228 nm size, had zeta potential −61.47 0.64 mV, exhibited notably higher anti-irritant activities compared alone, over 10 4 times, respectively. Furthermore, addition rhamnolipid solution dispersant provided nanofluid antibacterial againstStaphylococcus aureus. results indicate that rhamnolipid–PHB–ectoine nanoformulation shows significant agent anti-irritation, anti-UVB, capabilities.

Язык: Английский

Rhamnolipid-Modified PHB–Ectoine Nanoparticles for Multifunctional Skin Protection Against UVB, Irritation, and Bacteria DOI Creative Commons
Alma Tyara Simbara, Fera Faridatul Habibah, Rukman Hertadi

и другие.

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Rhamnolipid, poly(R)-3-hydroxybutyrate (PHB), and ectoine are sustainable compounds produced by specific bacteria known for their protective benefits, including promoting skin health in applications, such as facial wash, sunscreens, moisturizers. These have been extensively studied due to unique physicochemical properties biocompatibility. Leveraging these beneficial properties, this study aimed create a multifunctional formulation synthesizing nanoparticles from PHB ectoine, which acknowledged anti-ultraviolet B (UVB) anti-irritation properties. The covalent bonding of was achieved using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), the were through centrifugation. synthesized nanoparticle (PHB–ectoine NPs) physicochemically characterized tested anti-UVB vitro. characterization revealed homogeneous spherical shape with distinct layered structure, primarily composed carbon oxygen. PHB–ectoine NPs measured 527 ± 228 nm size, had zeta potential −61.47 0.64 mV, exhibited notably higher anti-irritant activities compared alone, over 10 4 times, respectively. Furthermore, addition rhamnolipid solution dispersant provided nanofluid antibacterial againstStaphylococcus aureus. results indicate that rhamnolipid–PHB–ectoine nanoformulation shows significant agent anti-irritation, anti-UVB, capabilities.

Язык: Английский

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