Neurosurgery Clinics of North America, Год журнала: 2023, Номер 35(1), С. 27 - 48
Опубликована: Сен. 22, 2023
Язык: Английский
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 7, 2025
Abstract Many biological systems display circadian and slow multi‐day rhythms, such as hormonal cardiac cycles. In patients with epilepsy, these cycles also manifest cyclical fluctuations in seizure propensity. However, symptoms are consequences of the complex interactions between underlying physiological, pathophysiological, external causes. Therefore, identifying an accurate model system that governs rhythms allows for a more reliable risk forecast targeted interventions. The primary aim is to develop personalized strategy inferring long‐term trajectories epileptiform activity and, consequently, individual undergoing ECoG sampling via implantable neurostimulation devices. To achieve this goal, Hankel alternative view Koopman (HAVOK) analysis adopted approximate linear representation nonlinear propensity dynamics. HAVOK framework leverages theory delay‐embedding decompose chaotic dynamics into leading delay‐embedded coordinates driven by low‐energy coordinate (i.e., forcing). findings reveal topology attractors cycles, showing seizures tend occur regions manifold strongly Moreover, it demonstrated identified forcings short periods up few days accurately predicts patients' slower which improves forecasting.
Язык: Английский
Процитировано
0
Epilepsy & Behavior, Год журнала: 2023, Номер 151, С. 109609 - 109609
Опубликована: Дек. 30, 2023
Язык: Английский
Процитировано
8
Frontiers in Neuroscience, Год журнала: 2022, Номер 16
Опубликована: Сен. 7, 2022
Epilepsy is a neurological disease characterized by spontaneous, unprovoked seizures. Various insults render the brain hyperexcitable and susceptible to seizure. Despite there being dozens of preventative anti-seizure medications available, these drugs fail control seizures in nearly 1 3 patients with epilepsy. Over last century, large body evidence has demonstrated that internal external rhythms can modify seizure phenotypes. Physiologically relevant shorter periodic rhythms, such as endogenous circadian sleep-state, well longer periodicity, including multidien menses, influence timing through poorly understood mechanisms. The purpose this review discuss findings from both human animal studies consider effect biologically on epilepsy seizure-associated death. Patients medically refractory are at increased risk sudden unexpected death (SUDEP). role some play nocturnal susceptibility SUDEP will also be discussed. While involvement been known for over applying rhythmic nature phenomenon management, particularly mitigating SUDEP, underutilized. As our understanding physiological improves, technology chronic intracranial epileptiform monitoring becomes more widespread, smaller less invasive, novel seizure-prediction technologies time-dependent chronotherapeutic management strategies realized.
Язык: Английский
Процитировано
13
npj Digital Medicine, Год журнала: 2023, Номер 6(1)
Опубликована: Март 23, 2023
The idea that abnormal human activities follow multi-day rhythms is found in ancient beliefs on the moon to modern clinical observations epilepsy and mood disorders. To explore healthy behavior our analysis includes over 300 million smartphone touchscreen interactions logging up 2 years of day-to-day (N401 subjects). At level each individual, we find a complex expression where occur scattered across diverse behaviors. With non-negative matrix factorization, extract reveal periods ranging from 7 52 days - cutting age gender. are likely free-running instead being ubiquitously driven by as they did not show broad population-level synchronization even though sampled population lived northern Europe. We propose common trait, but their consequences uniquely experienced behavior.
Язык: Английский
Процитировано
7
Neurosurgery Clinics of North America, Год журнала: 2023, Номер 35(1), С. 27 - 48
Опубликована: Сен. 22, 2023
Язык: Английский
Процитировано
6