Frontiers in Medicine, Год журнала: 2022, Номер 9
Опубликована: Июнь 20, 2022
Genetic and non-genetic factors are responsible for the high interindividual variability in response to SARS-CoV-2. Although numerous genetic polymorphisms have been identified as risk severe COVID-19, these remain understudied Latin-American populations. This study evaluated association of three polymorphisms:
Язык: Английский
Trends in Neurosciences, Год журнала: 2022, Номер 45(5), С. 358 - 368
Опубликована: Март 3, 2022
Язык: Английский
Процитировано
190
Immunity, Год журнала: 2022, Номер 55(5), С. 749 - 780
Опубликована: Май 1, 2022
Язык: Английский
Процитировано
155
Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 157, С. 113977 - 113977
Опубликована: Ноя. 7, 2022
COVID-19 is a worldwide pandemic caused by SARS-coronavirus-2 (SARS-CoV-2). Less than year after the emergence of Covid-19 pandemic, many vaccines have arrived on market with innovative technologies in field vaccinology. Based use messenger RNA (mRNA) encoding Spike SARS-Cov-2 protein or recombinant adenovirus vectors enabling gene to be introduced into our cells, these strategies make it possible envisage vaccination new light tools that are more scalable vaccine used so far. Faced appearance variants, which will gradually take precedence over strain at origin allow much faster update fight against some may escape neutralization antibodies. However, only policy based rapid and massive population but requiring supply sufficient doses could combat variants. Indeed, greater number infected individuals, virus multiplies, an increased risk variants viruses. This review discuss SARS-CoV-2 pathophysiology evolution approaches altered transmission platforms emphasize different mutations how they influence characteristics. Also, this article summarizes common implication genetic variety biomedical arbitrations.
Язык: Английский
Процитировано
89
Human Molecular Genetics, Год журнала: 2022, Номер 31(23), С. 3945 - 3966
Опубликована: Июль 15, 2022
Abstract Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis host genetic contribution to severe COVID-19 is important improve our understanding underlying mechanisms. Here, we describe an extended genome-wide association meta-analysis well-characterized cohort 3255 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway Germany/Austria, including stratified analyses based on age, sex severity, as well targeted chromosome Y haplotypes, human leukocyte antigen region SARS-CoV-2 peptidome. By inversion imputation, traced reported at 17q21.31 ~0.9-Mb polymorphism that creates two differentiated haplotypes characterized potential effects in detail. Our data, together 5th release summary statistics Host Genetics Initiative non-Caucasian individuals, also identified new locus 19q13.33, NAPSA, gene which expressed primarily alveolar cells responsible for gas exchange lung.
Язык: Английский
Процитировано
71
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Июнь 13, 2023
Abstract Some people remain healthier throughout life than others but the underlying reasons are poorly understood. Here we hypothesize this advantage is attributable in part to optimal immune resilience (IR), defined as capacity preserve and/or rapidly restore functions that promote disease resistance (immunocompetence) and control inflammation infectious diseases well other causes of inflammatory stress. We gauge IR levels with two distinct peripheral blood metrics quantify balance between (i) CD8 + CD4 T-cell (ii) gene expression signatures tracking longevity-associated immunocompetence mortality-associated inflammation. Profiles ~48,500 individuals collectively indicate some persons resist degradation both during aging when challenged varied stressors. With resistance, preservation tracked a lower risk HIV acquisition, AIDS development, symptomatic influenza infection, recurrent skin cancer; survival COVID-19 sepsis; (iii) longevity. potentially reversible by decreasing Overall, show trait observed across age spectrum, more common females, aligned specific immunocompetence-inflammation linked favorable immunity-dependent health outcomes. mechanisms have utility biomarkers for measuring improving
Язык: Английский
Процитировано
54
Viruses, Год журнала: 2022, Номер 14(6), С. 1297 - 1297
Опубликована: Июнь 14, 2022
This retrospective multi-center matched cohort study assessed the risk for severe COVID-19 (combination of severity indicators), intensive care unit (ICU) admission, and in-hospital mortality in hospitalized patients when infected with Omicron variant compared to Delta variant. The is based on a causal framework using individually-linked data from national registries. population consisted 954 (of which, 445 were Omicron) above 18 years old admitted Belgian hospital during autumn winter season 2021–2022, available viral genomic data. Patients hospital, whereas other possible confounders (demographics, comorbidities, vaccination status, socio-economic ICU occupancy) adjusted by multivariable logistic regression analysis. estimated standardized admission was significantly lower (RR = 0.63; 95% CI (0.30; 0.97) RR 0.56; (0.14; 0.99), respectively) variant, not different according SARS-CoV-2 0.78, (0.28–1.29)). demonstrates added value integrated clinical surveillance recognize multifactorial nature pathogenesis.
Язык: Английский
Процитировано
64
Translational Neurodegeneration, Год журнала: 2022, Номер 11(1)
Опубликована: Сен. 11, 2022
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a life-threatening disease, especially in elderly individuals and those with comorbidities. The predominant clinical manifestation of COVID-19 dysfunction, while neurological presentations are increasingly being recognized. SARS-CoV-2 invades host cells primarily via attachment the spike protein to angiotensin-converting enzyme (ACE2) receptor expressed on cell membranes. Patients Alzheimer's (AD) more susceptible infection prone outcomes. Recent studies have revealed some common risk factors for AD COVID-19. An understanding association between potential related mechanisms may lead development novel approaches treating both diseases. In present review, we first summarize central nervous system (CNS) then discuss associations shared key AD, focus ACE2 receptor, apolipoprotein E (APOE) genotype, age, neuroinflammation.
Язык: Английский
Процитировано
45
Proceedings of the National Academy of Sciences, Год журнала: 2022, Номер 119(21)
Опубликована: Май 20, 2022
Significance Middle East respiratory syndrome coronavirus (MERS-CoV) causes highly lethal disease. MERS-CoV encodes innate immune antagonists, including accessory proteins NS4a and NS4b, unique to the merbeco lineage of betacoronaviruses, nsp15 protein endoribonuclease (EndoU), conserved among all coronaviruses. While mutation each antagonist alone has little effect on immunity, infections with recombinant MERS-CoVs mutations EndoU in combination either or NS4b activate signaling pathways are attenuated for replication. Our data indicate that together suppress immunity during infection, optimize viral This is contrast SARS-CoV-2 which activates these thus more vulnerable host responses.
Язык: Английский
Процитировано
39
PLoS ONE, Год журнала: 2023, Номер 18(2), С. e0281750 - e0281750
Опубликована: Фев. 16, 2023
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been responsible for the recent pandemic since early 2020. Due to wide range of clinical symptoms this disease, from asymptomatic severe and critical forms, it seems that genetic differences among patients, along with other factors (such as gender, age, underlying diseases), can explain part variation in disease symptoms. The TMPRSS2 enzyme plays a vital role stages interaction SARS-CoV-2 host cells by facilitating viral entry. There is polymorphism gene, called rs12329760(C T) missense variant, which causes replacement valine methionine protein at position 160. present study investigated association between genotype severity 2019 (COVID-19) Iranian patients. 251 COVID-19 patients (151 mild 100 symptoms) was detected on genomic DNA extracted patients’ peripheral blood via ARMS-PCR method. Our results showed significant minor T allele ( P-value = 0.043) under dominant additive inheritance model. In conclusion, rs12329760 gene risk form contrast most previous studies variant European ancestry populations suggested protective allele. reiterate ethnic-specific alleles hidden unknown complexity behind susceptibility. However, further are needed address complex mechanisms determining severity.
Язык: Английский
Процитировано
30
Human Genomics, Год журнала: 2023, Номер 17(1)
Опубликована: Июль 24, 2023
Abstract Three and a half years after the pandemic outbreak, now that WHO has formally declared emergency is over, COVID-19 still significant global issue. Here, we focus on recent developments in genetic genomic research COVID-19, give an outlook state-of-the-art therapeutical approaches, as gradually transitioning to endemic situation. The sequencing characterization of rare alleles different populations made it possible identify numerous genes affect either susceptibility or severity disease. These findings provide beginning new avenues pan-ethnic therapeutic well potential screening protocols. causative virus, SARS-CoV-2, spotlight, but novel threatening virus could appear anywhere at any time. Therefore, continued vigilance further warranted. We also note emphatically prevent future pandemics other world-wide health crises, imperative capitalize what have learnt from COVID-19: specifically, regarding its origins, world’s response, insufficient preparedness. This requires unprecedented international collaboration timely data sharing for coordination effective response rapid implementation containment measures.
Язык: Английский
Процитировано
28