Frontiers in Medicine, Год журнала: 2022, Номер 9
Опубликована: Июнь 20, 2022
Genetic and non-genetic factors are responsible for the high interindividual variability in response to SARS-CoV-2. Although numerous genetic polymorphisms have been identified as risk severe COVID-19, these remain understudied Latin-American populations. This study evaluated association of three polymorphisms:
Язык: Английский
Scientific Reports, Год журнала: 2022, Номер 12(1)
Опубликована: Фев. 10, 2022
Abstract Chronic kidney disease (CKD) has been recognized as a highly prevalent risk factor for both the severity of coronavirus 2019 (COVID-19) and COVID-19 associated adverse outcomes. In this multicenter observational cohort study, we aim to determine mortality readmission rates patients hospitalized across varying CKD stages. We performed study among included in Dutch COVIDPredict cohort. The consists from March 2020 until July 2021 with PCR-confirmed SARS-CoV-2 infection or suspected CT scan-based CORADS score ≥ 4. A total 4151 were who 389 had history before admission. After adjusting all confounding covariables, stage 3a, 3b, 4 KTX (kidney transplantation), odds ratios death compared without ranged 1.96 8.94. demonstrate an evident increased 12-week rate chronic disease. Besides justified concerns transplant patients, clinicians should also be aware more severe outcomes vulnerability patients.
Язык: Английский
Процитировано
24
mBio, Год журнала: 2022, Номер 13(4)
Опубликована: Июль 12, 2022
Infectious diseases have shaped the human population genetic structure, and variation influences susceptibility to many viral diseases. However, a variety of challenges made implementation traditional Genome-wide Association Studies (GWAS) approaches study these infectious outcomes challenging. In contrast, mouse models provide an experimental control precision, which facilitates analyses mechanistic studies role on infection. Here we use mapping cross between two distinct Collaborative Cross strains with respect severe acute respiratory syndrome coronavirus (SARS-CoV) disease outcomes. We find several loci differential outcome for traits in context SARS-CoV Importantly, identify locus chromosome 9 that shows conserved synteny GWAS SARS-CoV-2 disease. follow-up confirm this locus, candidate genes, CCR9 CXCR6, both play key regulating severity SARS-CoV, SARS-CoV-2, distantly related bat sarbecovirus As such template using crosses characterize multitrait regulate pathogenic across species. IMPORTANCE Host is important determinant predicts following setting highly infections determinants underlying host mortality remain unclear. To elucidate pathogenesis outcomes, utilized (CC) reference as model alleles infections. Our findings reveal found regulator mice. Within identified validated CXCR6 regulators Specifically, are protective against SARS-related HKU3 virus This may be help genes humans.
Язык: Английский
Процитировано
23
BMC Medical Genomics, Год журнала: 2024, Номер 17(1)
Опубликована: Май 23, 2024
Abstract The symptoms of SARS-CoV-2 infection vary widely, ranging from asymptomatic cases to severe forms marked by acute respiratory distress syndrome, multi-organ damage, and fatalities. Studies indicate a correlation between specific genes susceptibility disease severity, particularly involving variants in linked inflammation immune responses. objective this study is investigate the association rs1800795 (− 174 G > C) rs1800797 597 A G) interleukin-6 (IL-6) promoter region infection. Additionally, we aim explore their with COVID-19 severity Moroccan population. In case-control study, enrolled 270 unvaccinated patients, consisting 132 138 asymptomatic-moderate COVID-19. included 339 SARS-CoV-2-negative group. Genotyping polymorphisms IL-6 gene was performed using predesigned TaqMan SNP genotyping. median age controls 50 years, while exhibited 61 years. individuals moderate had 36 We observed significant difference mild patients ( p < 0.0001), an noted gender = 0.011). allele genotype frequencies − 597G 174G C did not show associations 0.05). However, further analysis revealed that linkage disequilibrium indicated GC* haplotype (OR 0.04, 95% CI 0.01–0.30, 0.001) AG* 0.11, 0.03–0.46, 0.002) were significantly associated protection against Moreover, overdominant model, G/C found be protective development compared those G/G-C/C genotypes 0.03; OR 0.41, 0.18–0.96). correlations complete blood count markers, hematological D-dimer, C-reactive protein, ferritin levels according showed no differences (all Our findings provide valuable insights into pathogenesis COVID-19, suggesting genetic variations at may contribute within
Язык: Английский
Процитировано
5
ESMO Open, Год журнала: 2022, Номер 7(3), С. 100499 - 100499
Опубликована: Май 8, 2022
ESMO COVID-19 and CAncer REgistry (ESMO-CoCARE) is an international collaborative registry-based, cohort study gathering real-world data from Europe, Asia/Oceania Africa on the natural history, management outcomes of patients with cancer infected severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Язык: Английский
Процитировано
22
Frontiers in Medicine, Год журнала: 2022, Номер 9
Опубликована: Июнь 20, 2022
Genetic and non-genetic factors are responsible for the high interindividual variability in response to SARS-CoV-2. Although numerous genetic polymorphisms have been identified as risk severe COVID-19, these remain understudied Latin-American populations. This study evaluated association of three polymorphisms:
Язык: Английский
Процитировано
22