UBR5 in Tumor Biology: Exploring Mechanisms of Immune Regulation and Possible Therapeutic Implications in MPNST
Cancers,
Год журнала:
2025,
Номер
17(2), С. 161 - 161
Опубликована: Янв. 7, 2025
Malignant
peripheral
nerve
sheath
tumor
(MPNST)
is
a
rare
but
aggressive
soft-tissue
sarcoma
characterized
by
poor
response
to
therapy.
The
primary
treatment
remains
surgical
resection
with
negative
margins.
Nonetheless,
in
the
setting
of
neurofibromatosis
type
1
(NF1),
five-year
survival
rate
at
20-50%,
recurrence
occurring
up
50%
individuals.
For
patients
metastatic
and
unresectable
disease,
current
options
include
cytotoxic
chemotherapy,
which
offers
minimal
benefit,
most
die
within
five
years
diagnosis.
Despite
advances
targeted
therapy
focusing
on
inhibiting
Ras
signaling
its
downstream
effectors,
clinical
trials
report
highlighting
need
explore
alternative
pathways
MPNST
pathogenesis.
Here,
we
discuss
role
E3
ubiquitin
ligase,
UBR5,
cancer
progression
immune
modulation
across
various
malignancies,
including
breast,
lung,
ovarian
cancer.
We
focus
mechanisms
UBR5
contributes
tumorigenesis,
influence
microenvironment
modulation.
Additionally,
UBR5's
roles
normal
tissue
function,
DNA
damage
response,
metastasis,
therapeutic
resistance,
illustrating
multifaceted
contribution
biology.
evidence
implicating
evasion
highlight
potential
as
target
enhance
efficacy
checkpoint
blockade
(ICB)
MPNST,
typically
an
cold
microenvironment.
outline
immune-based
strategies
challenges
management,
ongoing
efforts
shift
landscape
ultimately,
suggest
that
targeting
could
be
novel
strategy
potentiate
ICB
therapy-mediated
anti-tumor
outcomes,
particularly
inoperable
or
disease.
Язык: Английский
Emerging roles of checkpoint molecules on B cells
Immunological Medicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 12
Опубликована: Янв. 17, 2025
Immune
checkpoint
molecules,
including
both
co-inhibitory
molecules
and
co-stimulatory
are
known
to
play
critical
roles
in
regulating
T-cell
responses.
During
the
last
decades,
immunotherapies
targeting
these
(such
as
programmed
cell
death
1
(PD-1),
lymphocyte
activation
gene
3
(LAG-3))
have
provided
clinical
benefits
many
cancers.
It
is
becoming
apparent
that
not
only
T
cells,
but
also
B
cells
a
capacity
express
some
molecules.
These
were
originally
thought
be
markers
for
regulatory
which
produce
IL-10,
recent
studies
suggest
(especially
immunoglobulin
mucin
domain
(TIM-1),
immunoreceptor
with
Ig
ITIM
domains
(TIGIT),
PD-1)
can
regulate
intrinsic
B-cell
functions.
Here,
we
focus
on
summarize
their
characteristics,
ligands,
functions
cells.
Язык: Английский
Dynamic roles of tumor-infiltrating B lymphocytes in cancer immunotherapy
Cancer Immunology Immunotherapy,
Год журнала:
2025,
Номер
74(3)
Опубликована: Фев. 1, 2025
The
amazing
diversity
of
B
cells
within
the
tumor
microenvironment
is
basis
for
diverse
development
cell-based
immunotherapies.
Here,
we
focus
on
elucidating
mechanisms
intervention
mediated
by
four
tumor-infiltrating
lymphocytes.
Naive
present
initial
antigen,
germinal
center
cell
subsets
enhance
antibody
affinity,
and
immunoglobulin
subtypes
exert
multiple
immune
effects,
while
regulatory
establish
tolerance.
Together
they
reflect
complexity
changing
dynamics
cancer
immunity.
Additionally,
have
investigated
dynamic
effects
lymphocytes
in
immunotherapy
their
relationship
to
prognosis,
providing
new
insights
into
potential
treatment
strategies
patients.
Язык: Английский
From heterogeneity to prognosis: understanding the complexity of tertiary lymphoid structures in tumors
Molecular Biology Reports,
Год журнала:
2025,
Номер
52(1)
Опубликована: Фев. 4, 2025
Язык: Английский
B cells in non-lymphoid tissues
Nature reviews. Immunology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Язык: Английский
Revealing the role of regulatory b cells in cancer: development, function and treatment significance
Cancer Immunology Immunotherapy,
Год журнала:
2025,
Номер
74(4)
Опубликована: Фев. 25, 2025
B
cells
are
essential
components
of
the
immune
response,
primarily
recognized
for
their
ability
to
produce
antibodies.
However,
emerging
research
reveals
important
roles
in
regulating
responses
and
influencing
tumor
development,
independent
The
connection
between
progression
alterations
microenvironment
is
well-established,
as
infiltrating
can
enhance
survival
by
modifying
surroundings.
Despite
this,
majority
studies
have
focused
on
T
macrophages,
creating
a
gap
our
understanding
cells.
Regulatory
(Bregs)
represent
crucial
subpopulation
that
plays
significant
role
maintaining
balance.
They
may
substantial
impact
immunity
negatively
tumor-infiltrating
This
paper
reviews
existing
literature
Bregs,
examining
phenotypes,
functions,
mechanisms
through
which
they
exert
regulatory
effects.
Furthermore,
we
highlight
potential
interventional
prognostic
significance
cancer
therapy.
By
addressing
current
gaps
knowledge
regarding
Bregs
within
tumors,
hope
inspire
further
could
lead
innovative
treatments
improved
outcomes
patients.
Язык: Английский
Single-cell and spatial transcriptomic analysis reveals tumor cell heterogeneity and underlying molecular program in colorectal cancer
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 12, 2025
Background
Colorectal
cancer
(CRC)
is
a
highly
heterogeneous
tumor,
with
significant
variation
in
malignant
cells,
posing
challenges
for
treatment
and
prognosis.
However,
this
heterogeneity
offers
opportunities
personalized
therapy.
Methods
The
consensus
non-negative
matrix
factorization
algorithm
was
employed
to
analyze
single-cell
transcriptomic
data
from
CRC,
which
helped
identify
cell
expression
programs
(MCEPs).
Subsequently,
crosstalk
network
linking
MCEPs
immune/stromal
trajectory
development
constructed
using
Monocle3
NicheNet.
Additionally,
bulk
RNA-seq
were
utilized
systematically
explore
the
relationships
between
MCEPs,
clinical
features,
genetic
mutations.
A
prognostic
model
then
established
through
Lasso
Cox
regression
analyses,
integrating
into
nomogram
risk
prediction.
Furthermore,
key
genes
associated
their
potential
therapeutic
targets
identified
protein-protein
interaction
networks,
followed
by
molecular
docking
predict
drug-binding
affinity.
Results
We
classified
CRC
transcriptional
states
eight
distinct
successfully
networks
these
immune
or
stromal
cells.
containing
15
developed,
demonstrating
an
AUC
greater
than
0.8
evaluation
over
1
10
years
when
combined
features.
drug
target
gene
TIMP1
identified,
several
targeted
drugs
discovered.
Conclusion
This
study
demonstrated
that
characterization
of
could
effectively
reveal
biological
features
tumors
like
exhibit
tumor
prognosis
assessment.
Our
research
provides
new
theoretical
practical
directions
Язык: Английский
Decoding YOD1: Insights into tumour regulation and translational opportunities
Biochemical Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 116889 - 116889
Опубликована: Март 1, 2025
Язык: Английский
Pancreatic ductal adenocarcinoma microenvironment: Soluble factors and cancer associated fibroblasts as modulators of NK cell functions
Immunology Letters,
Год журнала:
2024,
Номер
269, С. 106898 - 106898
Опубликована: Июль 15, 2024
Pancreatic
Ductal
Adenocarcinoma
(PDAC)
is
the
most
frequent
pancreatic
cancer
and
represents
one
of
aggressive
human
neoplasms.
Typically
identified
at
advance
stage
disease,
PDAC
tumors
are
unresectable
resistant
to
standard
therapies.
The
immunosuppressive
microenvironment
in
impedes
tumor
control
but
a
greater
understanding
complex
stromal
interactions
within
(TME)
development
strategies
capable
restoring
antitumor
effector
immune
responses
could
be
crucial
fight
this
its
spread.
Natural
Killer
(NK)
cells
play
role
immunosurveillance
represent
an
attractive
target
for
immunotherapies,
both
as
cell
therapy
pharmaceutical
target.
This
review
describes
some
components
TME
(collagens,
soluble
factors
fibroblasts)
that
can
influence
presence,
phenotype
function
NK
patients
tissue.
focused
overview
highlights
therapeutic
relevance
dissecting
composition
define
new
cell-based
immunotherapies
improve
treatment
PDAC.
Язык: Английский