Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19

Viruses, Год журнала: 2025, Номер 17(1), С. 98 - 98

Опубликована: Янв. 14, 2025

Post-acute sequelae of COVID-19 (PASC) are a diverse set symptoms and syndromes driven by dysfunction multiple organ systems that can persist for years negatively impact the quality life millions individuals. We currently lack specific therapeutics patients with PASC, due in part to an incomplete understanding its pathogenesis, especially non-pulmonary sequelae. Here, we discuss three animal models have been utilized investigate PASC: non-human primates (NHPs), hamsters, mice. focus on neurological, gastrointestinal, cardiovascular PASC highlight advances mechanistic insight made using these models, as well discussing warrant continued intensive research.

Язык: Английский

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Alterations in non-REM sleep and EEG spectra precede REM-sleep deficits in a model of synucleinopathy

Journal of Parkinson s Disease, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Background Sleep disturbances often precede motor symptoms in neurodegenerative diseases like Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Neuroinflammation is implicated PD pathophysiology may contribute to non-motor such as sleep disturbances. The Thy1-αSyn mouse model, overexpressing human alpha-synuclein (αSyn), mimics key aspects of DLB, making it valuable for studying related neuroinflammatory changes. Objective To investigate early-stage alterations architecture, electroencephalographic (EEG) patterns, neuroinflammation mice. Methods We used telemetric EEG/electromyography (EMG) video surveillance compare patterns EEG spectral power between 2.5- 4.5-month-old male transgenic mice wild-type littermates. was assessed by examining microglial (Iba1) astrocytic (GFAP) activation sleep-regulating brain regions. Results showed decreased resting wake time increased non-REM sleep, altered bout frequency length, indicating significant architecture Spectral analysis revealed a shift from higher lower bands, suggesting early neural circuitry disruptions due αSyn overexpression. Significant observed at 3 months, astrogliosis progressing 5 months regions, that the Conclusions Early-stage exhibit changes, shifts, alterations. These findings suggest play role initial pathophysiological changes synucleinopathies. Sleep, EEG, could serve biomarkers these diseases.

Язык: Английский

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Infections in the Etiology of Parkinson’s Disease and Synucleinopathies: A Renewed Perspective, Mechanistic Insights, and Therapeutic Implications

Journal of Parkinson s Disease, Год журнала: 2024, Номер unknown, С. 1 - 29

Опубликована: Сен. 25, 2024

Increasing evidence suggests a potential role for infectious pathogens in the etiology of synucleinopathies, group age-related neurodegenerative disorders including Parkinson’s disease (PD), multiple system atrophy and dementia with Lewy bodies. In this review, we discuss link between infections synucleinopathies from historical perspective, present emerging that supports link, address current research challenges focus on neuroinflammation. Infectious can elicit neuroinflammatory response modulate genetic risk PD related synucleinopathies. The mechanisms how might be linked as well overlap immune cellular pathways affected by virulent disease-related factors are discussed. Here, an important α-synuclein against is emerging. Critical methodological knowledge gaps addressed, provide new future perspectives to these gaps. Understanding neuroinflammation influence will essential development early diagnostic tools novel therapies.

Язык: Английский

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SARS-CoV-2 Infection and Alpha-Synucleinopathies: Potential Links and Underlying Mechanisms

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12079 - 12079

Опубликована: Ноя. 10, 2024

Alpha-synuclein (α-syn) is a 140-amino-acid, intrinsically disordered, soluble protein that abundantly present in the brain. It plays crucial role maintaining cellular structures and organelle functions, particularly supporting synaptic plasticity regulating neurotransmitter turnover. However, for reasons not yet fully understood, α-syn can lose its physiological begin to aggregate. This altered disrupts dopaminergic transmission causes both presynaptic postsynaptic dysfunction, ultimately leading cell death. A group of neurodegenerative diseases known as α-synucleinopathies characterized by intracellular accumulation deposits specific neuronal glial cells within certain brain regions. In addition Parkinson's disease (PD), these conditions include dementia with Lewy bodies (DLBs), multiple system atrophy (MSA), pure autonomic failure (PAF), REM sleep behavior disorder (RBD). Given disorders are associated α-syn-related neuroinflammation-and considering SARS-CoV-2 infection has been shown affect nervous system, COVID-19 patients experiencing neurological symptoms-it proposed may contribute neurodegeneration PD other promoting misfolding aggregation. this review, we focus on whether could act an environmental trigger facilitates onset or progression α-synucleinopathies. Specifically, new evidence potential modulating function discuss causal relationship between development parkinsonism-like symptoms.

Язык: Английский

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Alpha-synuclein pathology enhances peripheral and CNS immune responses to bacterial endotoxins

Neurobiology of Disease, Год журнала: 2024, Номер 205, С. 106773 - 106773

Опубликована: Дек. 20, 2024

Язык: Английский

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Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, Olea europaea L., in Long COVID and Other Conditions Involving Cognitive Impairment

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11040 - 11040

Опубликована: Окт. 14, 2024

The European olive tree, Olea europaea L., and its polyphenols hold great therapeutic potential to treat neuroinflammation cognitive impairment. This review examines the evidence for anti-inflammatory neuroprotective actions of their in treatment long COVID neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS). Key findings suggest that exhibit antioxidant, anti-inflammatory, neuroprotective, antiviral properties, making them promising candidates intervention, especially when formulated unique combinations. Recommendations future research directions include elucidating molecular pathways through mechanistic studies, exploring implications polyphenol supplementation, conducting clinical trials assess efficacy safety. Investigating synergistic effects with other agents addressing different targets is suggested further exploration. reviewed strengthens translational value conditions involving dysfunction emphasizes novelty new formulations.

Язык: Английский

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Sars-Cov-2 variants mediated tissue-specific metabolomic reprogramming determines the disease pathophysiology in a hamster model

Brain Behavior and Immunity, Год журнала: 2024, Номер 123, С. 914 - 927

Опубликована: Окт. 30, 2024

Язык: Английский

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