Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Abstract
Natural
remedies
are
gaining
attention
as
promising
approaches
to
alleviating
inflammation,
yet
their
full
potential
is
often
limited
by
challenges
such
poor
bioavailability
and
suboptimal
therapeutic
effects.
To
overcome
these
limitations,
we
have
developed
a
novel
nano-antioxidant
(EK)
based
on
epigallocatechin
gallate
(EGCG)
aimed
at
enhancing
the
oral
systemic
bioavailability,
well
anti-inflammatory
efficacy,
of
curcumin
(Cur)
in
conditions
acute
colon
kidney
inflammation.
EK
synthesized
using
straightforward
Mannich
reaction
between
EGCG
L-lysine
(K),
resulting
formation
oligomers.
These
oligomers
spontaneously
self-assemble
into
nanoparticles
with
spherical
morphology
an
average
diameter
approximately
160
nm.
In
vitro
studies
reveal
that
exhibit
remarkable
radical-scavenging
capabilities
effectively
regulate
redox
processes
within
macrophages,
key
component
body’s
inflammatory
response.
By
efficiently
encapsulating
nanoparticles,
create
Cur@EK,
formulation
demonstrates
synergistic
effect.
Specifically,
Cur@EK
significantly
reduces
levels
pro-inflammatory
cytokines
TNF-α
IL-6
while
increasing
cytokine
IL-10
lipopolysaccharide-stimulated
highlighting
its
potent
properties.
When
administered
either
orally
or
intravenously,
shows
superior
compared
free
exhibits
pronounced
effects
mouse
models
ulcerative
colitis
injury.
findings
suggest
platform
not
only
enhances
but
also
amplifies
impact,
offering
new
avenue
for
treatment
management
inflammation
both
contexts.
Future Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown, С. 1 - 10
Опубликована: Фев. 14, 2025
Background
Upregulation
of
Cyclooxygenase-2
(COX-2)
in
a
variety
cancer
cell
lines,
key
enzyme
prostaglandin
biosynthesis,
relative
to
surrounding
normal
tissues
results
the
use
COX-2
protein
as
an
attractive
molecular
target
for
many
anticancer
therapeutics.
This
could
have
significant
implication
selective
destruction
cells
via
photodynamic
therapy
effects,
leaving
tissue
intact.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
Strategically
targeting
lymph
nodes
(LNs)
to
orchestrate
the
initiation
and
regulation
of
adaptive
immune
responses
is
one
most
pressing
challenges
in
context
vaccination.
Herein,
a
series
polymer-TLR
agonist
conjugates
(PTACs)
developed
investigate
impact
dendritic-topological
characteristics
on
their
LN
activity
vivo,
molecular
weight
(MW)
pharmacokinetics
support
homing.
Notably,
dendritic
6-arm
PTAC
with
MW
60
kDa
(6A-PTAC-60k)
rapidly
delivered
cargo
draining
LNs
after
administration
peripheral
tissues.
Specifically,
this
topologic
structure
ameliorated
behavior
within
lymphatic
vessels
LNs,
including
an
elevated
amount
TLR7/8
improved
distribution
pattern
among
barrier
cells
cells,
increased
permeability,
prolonged
retention.
Furthermore,
6A-PTAC-60k
formulation
induced
broad
antibody
T
cell
responses,
enhancing
vaccine
immunogenicity
suppressing
tumor
growth.
The
results
revealed
that
both
topology
polymers
are
crucial
factors
for
immunoadjuvant
functional
which,
turn,
enhanced
formulation.
This
study
may
provide
chemical
structural
basis
optimizing
design
delivery
systems.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 23, 2025
Abstract
Co‐assembled
nanodrugs
provide
significant
advantages
in
cancer
treatment
and
drug
delivery,
yet
effective
screening
methods
to
identify
molecular
combinations
for
co‐assembly
are
lacking.
This
study
presents
a
strategy
integrating
ligand‐based
virtual
(LBVS)
density
functional
theory
(DFT)
calculations
explore
new
with
capabilities.
The
accuracy
of
this
was
validated
by
synthesizing
various
co‐assembled
under
mild
conditions.
Vinpocetine
(Vin)
lenvatinib
(Len)
representative
that
can
directly
co‐assemble
into
nanoparticles
(NPs)
through
hydrogen
bonding,
van
der
Waals
forces,
π‐π
interactions.
These
NPs
were
further
functionalized
polyethylene
glycol
(PEG),
resulting
PEG‐L/V
exhibited
enhanced
stability
biocompatibility.
In
addition,
respond
acidic
conditions
release
Vin
Len,
working
synergistically
induce
cell
cycle
arrest
apoptosis
tumor
cells
vitro
while
also
inhibiting
xenograft
growth
vivo.
RNA
sequencing
(RNA‐seq)
analysis
revealed
the
mechanisms
distinct
from
those
single
drugs.
demonstrates
feasibility
utilizing
computational
approach
combining
LBVS
DFT
small
molecules
capabilities,
leading
innovative
anticancer
strategies.
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Positive
surgical
margins
following
radical
prostatectomy
significantly
contribute
to
tumor
recurrence.
While
systemic
chemotherapy
demonstrates
limited
efficacy
in
this
context,
local
drug
delivery
systems
based
on
nanomaterials
offer
promising
strategies
address
issue
by
modifying
release
kinetics
and
distribution,
thereby
enhancing
antitumor
effects
while
minimizing
the
toxicities
associated
with
chemotherapy.
In
study,
we
utilized
electrospun
nanofibrous
mats
loaded
docetaxel
for
sustained
delivery.
vitro
experiments
demonstrated
that
these
implantable
drug-loaded
effectively
inhibited
prostate
cancer
cell
growth,
induced
cycle
arrest,
promoted
apoptosis.
animal
models,
exhibited
prominent
therapeutic
positive
postoperatively.
Importantly,
docetaxel-loaded
modulated
immune
microenvironment
suppressing
M2-like
macrophages,
increasing
ratio
between
M1-
CD8+
T-cell
infiltration.
Local
administration
reduced
toxicity
compared
summary,
developed
an
mat
localized
delivery,
which
offers
a
prospective
strategy
managing
after
surgery.
