Cleveland Clinic Journal of Medicine, Год журнала: 2023, Номер 90(12), С. 729 - 734
Опубликована: Дек. 1, 2023
Язык: Английский
JAMA Network Open, Год журнала: 2024, Номер 7(7), С. e2423555 - e2423555
Опубликована: Июль 24, 2024
Importance Chronic symptoms reported following an infection with SARS-CoV-2, such as cognitive problems, overlap included in the definition of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Objective To evaluate prevalence ME/CFS-like illness subsequent to acute SARS-CoV-2 infection, changes ME/CFS through 12 months follow-up, and association test results at infection–like index illness. Design, Setting, Participants This prospective, multisite, longitudinal cohort study (Innovative Support for Patients Infections Registry [INSPIRE]) enrolled participants from December 11, 2020, August 29, 2022. were adults aged 18 64 years suggestive who received a US Food Drug Administration–approved time did not die or withdraw by 3 months. Follow-up surveys collected February 28, 2023. Exposure COVID-19 status (positive vs negative) enrollment. Main Outcome Measures The main outcome was weighted proportion based on 2015 Institute Medicine clinical case using self-reported symptoms. Results A total 4378 study. Most female (3226 [68.1%]). Mean (SD) age 37.8 (11.8) years. survey completion rates ranged 38.7% (3613 4738 participants) 76.3% (1835 4738) decreased over time. identified change significantly follow-up similar COVID-19–positive (range, 2.8%-3.7%) COVID-19–negative 3.1%-4.5%) groups. Adjusted analyses revealed no significant difference odds any point between individuals (marginal ratio range, 0.84 [95% CI, 0.42-1.67] 1.18 0.55-2.51]). Conclusions Relevance In this prospective study, there evidence that differed those infected without up after infection. 3% 4% would impose high societal burden given millions persons SARS-CoV-2.
Язык: Английский
Процитировано
5
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Март 28, 2025
Many studies have investigated symptoms, comorbidities, demographic factors, and vaccine effects in relation to long COVID (LC-19) across global populations. However, a number of these shortcomings, such as inadequate LC-19 categorisation, lack sex disaggregation, or narrow focus on certain risk factors like symptoms comorbidities alone. We address gaps by investigating the present during acute phase primary COVID-19 infection among patients with comparing them typical non-Long patients. Additionally, we assess impact vaccination Drawing data from Regional Health System Region Murcia southeastern Spain, our analysis includes comprehensive information clinical hospitalisation records, details over 675126 10 hospitals. calculated age sex-adjusted odds ratios (AOR) identify protective for LC-19. Our findings reveal distinct symptomatology, comorbidity patterns, characteristics versus those COVID-19. Factors age, female (AOR = 1.39, adjusted p < 0.001), chest pain > 1.55, 0.001) hyposmia 1.5, significantly increase developing demonstrates strong effect, vaccinated individuals having markedly lower 0.10, highlighting importance reducing susceptibility. Interestingly, show no significant differences when disaggregated type patient. Vaccination before is most important factor notably decreases likelihood COVID. Particularly, mRNA vaccines offer more protection against than viral vector-based 0.48). developed model predict that incorporates all studied achieving balanced accuracy 73% ROC-AUC 0.80. This available free online calculator, accessible at ( Calculator ).
Язык: Английский
Процитировано
0
Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Июль 5, 2024
Background The neurological symptoms of Long COVID (LC) and the impact neuropsychological manifestations on people’s daily lives have been extensively described. Although a large body literature describes symptoms, validating this with objective measures is important. This study aims to identify describe effects cognition, balance, retinal fundus, determine whether duration influences cognitive impairment. Methods cross-sectional involved LC volunteers complaint from public health centers in northern Barcelona who participated between January 2022 March 2023. collected sociodemographic characteristics, information substance use, comorbidities, clinical data related COVID-19. We measured five domains using battery tests. Balance was assessed through posturography vascular involvement by retinography. Results A total 166 people complaints participated, 80.72% were women mean age 49.28 ± 8.39 years. most common self-reported concentration memory deficit (98.80%), brain fog (82.53%) insomnia (71.17%). 68.67% presented at least one domain, executive functions being frequent (43.98%). 51.52% participants exhibited dysfunctional pattern 9.2% showed some alteration retina. There no statistically significant differences impairment symptom duration. Conclusion Our findings contribute more comprehensive understanding pathology associated COVID. They highlight diversity presence abnormal balance patterns, These underscore necessity addressing management condition primary care follow-up pursuit multidisciplinary treatment.
Язык: Английский
Процитировано
4
Critical Care, Год журнала: 2024, Номер 28(1)
Опубликована: Авг. 29, 2024
Long-Covid (LC), Post-Sepsis-Syndrome (PSS) and Post-Intensive-Care-Syndrome (PICS) show remarkable overlaps in their clinical presentation. Nevertheless, it is unclear if they are distinct syndromes, which may co-occur the same patient, or three different labels to describe similar symptoms, assigned on basis patient history professional perspective of treating physician. Therefore, we reviewed current literature relation between LC, PSS PICS. To date, syndromes cannot reliably be distinguished due similarities presentation as share cognitive, psychological physical impairments with only probabilities occurrence a heterogeneity individual expression. The diagnosis furthermore hindered by lack specific diagnostic tools. It can concluded that survivors after COVID-19 sepsis likely have more frequent severe consequences than patients milder courses, some COVID-19-specific sequelae, e.g. an increased risk for venous thromboembolism 30 days acute disease, occur less often other causes. Patients profit from leveraging synergies PICS, LC treatment well experiences gained infection-associated chronic conditions general. Disentangling molecular pathomechanisms enable future targeted therapies go beyond symptomatic treatment.
Язык: Английский
Процитировано
4
Exploration of Musculoskeletal Diseases, Год журнала: 2025, Номер unknown
Опубликована: Янв. 22, 2025
Chronic pain is a common problem in rheumatology. A distinction made between nociceptive and nociplastic pain. Nociceptive is, for example, mechanistically explained by persistent inflammation. Neuropathic caused nerve damage of various possible causes. In contrast, not due to tissue or lesion the somatosensory nervous system—at least with currently available techniques. Nociplastic based on an altered perception through modulation stimulus processing. The concept central sensitization, together other neurobiological psychosocial mechanisms, considered be best explanation such conditions. syndrome fibromyalgia (FM), plays major role rheumatology—both terms differential diagnosis because management inflammatory rheumatic diseases can more difficult simultaneous presence FM. During coronavirus pandemic, syndromes similarities FM were described following COVID-19 infection. There growing scientific controversy as whether so-called long COVID (LCS) separate entity just variant
Язык: Английский
Процитировано
0
Immunity Inflammation and Disease, Год журнала: 2025, Номер 13(1)
Опубликована: Янв. 1, 2025
ABSTRACT Background Long COVID, a heterogeneous condition characterized by range of physical and neuropsychiatric presentations, can be presented with proportion COVID‐19‐infected individuals. Methods Transcriptomic data sets those within gene expression profiles COVID‐19, long healthy controls were retrieved from the GEO database. Differentially expressed genes (DEGs) falling under COVID‐19 COVID identified R packages, contemporaneously conducted module detection was performed Modular Pharmacology Platform ( http://112.86.129.72:48081/ ). The integration both DEGs differentially module‐genes (DEMGs) regarding intersected following Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), Set Enrichment Analysis (GSEA). Results There 11 62 modules, 1837 179 DEGs, as well 103 508 DEMGs acquiring for notably enriched in immune‐correlated signaling pathways. immune infiltrating cells comparatively respectively assessed via CIBERSORT, ssGSEA, xCell algorithms. Subsequently, screening hub involved employing SVM‐RFE, RF, XGBoost algorithms, logistic regression analysis. Among 67 candidate processed machine learning algorithms regression, subgroup consisting CEP55, CDCA2, MELK, DEPDC1B, at last potential biomarkers predicting risk progression into after infections. performance quantified ROC value 0.8762542, which proved combination provided highest performance. Conclusions In summary, we infection, could partly elucidation associated molecular mechanisms COVID.
Язык: Английский
Процитировано
0
Zeitschrift für Rheumatologie, Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
Язык: Английский
Процитировано
0
COVID, Год журнала: 2025, Номер 5(3), С. 41 - 41
Опубликована: Март 12, 2025
On 11 March 2020, the World Health Organization (WHO) declared a pandemic caused by SARS-CoV-2, raising global health concerns. Reports of persistent and new symptoms following acute phase infection highlighted complexities recovery prompted investigation what is now termed long COVID. Officially recognized WHO in October 2021, COVID presents various implications, though terminology—such as post-COVID syndrome post-acute sequelae COVID-19 (PASC)—remains inconsistent, complicating diagnostic standardization. Long affects an estimated 10% to 30% SARS-CoV-2-infected individuals, with common including fatigue, dyspnea, cognitive dysfunction, joint pain, all which significantly impair quality life. Public perception influenced factors like education history, while misinformation stigma hinder accurate diagnosis treatment. The absence biomarkers overlap other post-viral syndromes further complicate clinical recognition. Experts emphasize need for refined criteria integrated strategies combining biomedical research, public policy, educational initiatives improve management, address healthcare inequalities, mitigate impacts This review unveils state art knowledge gaps encourage discussion, aim achieving better decision-making awareness related
Язык: Английский
Процитировано
0
Annals of the Rheumatic Diseases, Год журнала: 2024, Номер 83(7), С. e16 - e16
Опубликована: Янв. 3, 2024
Язык: Английский
Процитировано
2
American Journal of Epidemiology, Год журнала: 2024, Номер 193(7), С. 1059 - 1060
Опубликована: Март 15, 2024
Journal Article Corrected proof Re: "Postacute symptoms 4 months after SARS-CoV-2 infection during the Omicron period: a nationwide Danish questionnaire study" Get access Bronner P Gonçalves Corresponding author: P. Gonçalves, Faculty of Health and Medical Sciences, University Surrey, Surrey Research Park, 30 Priestly Road, Guildford GU2 7YH, United Kingdom ([email protected]) Search for other works by this author on: Oxford Academic PubMed Google Scholar American Epidemiology, kwae021, https://doi.org/10.1093/aje/kwae021 Published: 15 March 2024 history Received: 17 December 2023 Revision received: 27 February Accepted: 12 typeset: 10 May
Язык: Английский
Процитировано
2