Journal of the Formosan Medical Association,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
The
COVID-19
pandemic
has
had
a
profound
impact
globally,
particularly
in
high-risk
populations
such
as
those
with
underlying
health
conditions.
In
response
to
the
evolving
landscape
and
recent
surge
confirmed
cases
Taiwan,
Taiwan
Association
of
Family
Medicine
(TAFM)
established
consensus
on
vaccine
recommendations
for
vulnerable
groups
through
comprehensive
literature
review,
expert
panel
discussions,
practice-oriented
formulation
procedure
develop
evidence-based
guidance.
Its
key
findings
highlight
increased
risk
severe
outcomes
among
individuals
disorders
diabetes,
obesity,
chronic
kidney
disease,
cardiovascular
respiratory
illness.
It
emphasizes
safety
effectiveness
vaccines,
mRNA
these
populations.
underscores
critical
role
family
medicine
physicians
response,
including
routine
screening,
education,
vaccination
delivery,
continuous
research
optimize
strategies.
Ongoing
monitoring,
adaptation,
collaborative
efforts
will
be
essential
ensure
continued
landscape.
conclusion,
TAFM
provide
robust
framework
guide
healthcare
providers
policymakers
tailoring
address
unique
needs
are
an
applicable
template
neighboring
countries.
Abstract
Although
azvudine
has
become
a
priority
in
the
treatment
of
SARS‐CoV‐2,
its
effectiveness
and
safety
among
COVID‐19
patients
who
already
have
chronic
respiratory
diseases
(CRDs)
not
been
sufficiently
validated.
A
retrospective,
multicenter
cohort
study
involving
10
hospitals
Henan
Province
was
performed
to
assess
inpatients
with
CRDs
(Clinical
Trial
Registration
Number:
NCT06349655).
Azvudine
recipients
control
group
were
matched
at
1:1
ratio
using
propensity
scores.
The
clinical
outcomes
(all‐cause
death
composite
disease
progression)
analyzed
Kaplan‒Meier
Cox
regression
analyses,
additional
subgroup
sensitivity
analyses
performed.
Eighteen
features
included
construct
nomogram
for
predicting
survival
CRDs.
Out
37,606
hospitalized
patients,
1462
controls
analysis.
results
multivariate
demonstrated
that
contrast
controls,
use
associated
decreased
risk
all‐cause
pre‐existing
(log‐rank:
p
=
.012;
HR:
0.73;
95%
CI:
0.553‒0.956);
but
significantly
different
terms
progression
.82;
1.15;
0.948‒1.383).
An
analysis
subgroups
three
appraisals
validate
above
outcomes.
number
type
adverse
events
acceptable.
concordance
index
(0.8499,
0.8497)
area
under
curve
(86.1%,
80.4%)
showed
satisfactory
discriminative
ability
training
test
sets.
could
be
effective
reducing
had
few
serious
events.
Immunological Reviews,
Год журнала:
2025,
Номер
330(1)
Опубликована: Фев. 24, 2025
Chronic
lung
diseases
including
asthma
are
characterized
by
an
abnormal
immune
response
and
active
tissue
remodeling.
These
changes
in
the
architecture
of
a
fundamental
part
pathology
across
life
course
patients
suffering
from
asthma.
Current
treatments
aim
at
dampening
system
hyperactivation,
but
effective
drugs
targeting
stromal
or
acellular
structures
still
lacking.
This
is
mainly
due
to
lack
detailed
understanding
composition
large
airways
cellular
interactions
taking
place
this
niche.
We
others
have
revealed
multiple
aspects
spatial
airway
wall
airborne
insults.
In
review,
we
discuss
four
elements
that
believe
should
be
focus
future
research
course,
increase
improve
therapies:
(i)
specialized
niches,
(ii)
3D
epithelium,
(iii)
extracellular
matrix,
(iv)
vasculature.
components
comprise
main
wall,
each
playing
key
role
development
directing
response.
summarize
promising
directions
will
enhance
research,
ultimately
benefiting
with
Animal Models and Experimental Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Abstract
The
World
Health
Organization
has
declared
that
COVID‐19
no
longer
constitutes
a
“public
health
emergency
of
international
concern,”
yet
the
long‐term
impact
SARS‐CoV‐2
infection
on
bone
continues
to
pose
new
challenges
for
global
public
health.
In
recent
years,
numerous
animal
model
and
clinical
studies
have
revealed
severe
acute
respiratory
syndrome
coronavirus
2
(SARS‐CoV‐2)
can
lead
secondary
osteoporosis.
mechanisms
involved
are
related
virus's
direct
effects
tissue,
dysregulation
body's
inflammatory
response,
hypoxia,
noncoding
RNA
imbalance,
metabolic
abnormalities.
Although
these
unveiled
connection
between
osteoporosis,
current
research
is
not
comprehensive
in
depth.
Future
needed
evaluate
density
metabolism,
elucidate
specific
pathogenesis,
explore
potential
interventions.
This
review
aims
collate
existing
literature
infection‐induced
summarize
underlying
mechanisms,
provide
direction
future
research.
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
Abstract
As
COVID-19
primarily
affects
the
respiratory
system,
it
may
have
impacted
utilization
patterns
of
drugs
used
in
obstructive
airway
diseases
(DOADs).
We
examined
nationwide
DOAD
trends
before,
during,
and
after
pandemic
measures.
collected
data
on
DOADs
(ATC-Code:
R03)
between
01.01.2017–28.02.2023
from
IQVIA-Turkey.
National
outpatient
sales
prescription
projections
were
converted
into
consumption
data,
expressed
as
defined
daily
dose
per
1,000
inhabitants
(DID).
compared
mean
monthly
consumption,
costs,
quarterly
use
across
"before
restrictions"
(BfR),
"during
(DuR),
"after
(AfR)
periods.
identified
433.5
million
units
consumed,
costing
€3.3
billion;
inhaled-DOADs
accounted
for
73.1%.
Mean
remained
stable
(BfR:
67.8
±
3.1
DID;
DuR:
74.2
12.5
AfR:
14.6
p
>
0.05).
Inhaled-DOADs
exhibited
a
similar
pattern,
except
anticholinergics
with
significant
increase
DuR
(19.4
3.3
DID)
to
BfR
(16.1
2.3
DID,
<
0.001).
Also
inhaled-corticosteroid
monotherapy
rose
significantly
(4.1
0.9
AfR
(5.3
1.3
Montelukast,
constituting
76.6%
systemic-DOADs,
had
higher
(15.0
2.8
than
(11.7
2.2
0.001)
(12.9
2.4
Overall
prescriptions
declined
trended
upward
but
didn’t
reach
pre-pandemic
levels,
new
users
montelukast
long-acting
beta
agonists.
Our
study
showed
increased
inhaled
anticholinergics,
glucocorticoid
monotherapy,
within
generally
overall
utilization.
This
reflect
varied
responses
bronchodilation
anti-inflammatory
treatment
needs
during
beyond.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Окт. 18, 2024
In
this
mini
review,
we
explore
the
complex
network
of
inflammatory
reactions
incited
by
SARS-CoV-2
infection,
which
extends
its
reach
well
beyond
respiratory
domain
to
influence
various
organ
systems.
Synthesizing
existing
literature,
it
elucidates
how
hyperinflammation
observed
in
COVID-19
patients
affects
multiple
systems
leading
physiological
impairments
that
can
persist
over
long
after
resolution
infection.
By
exploring
systemic
manifestations
cascade,
from
acute
distress
syndrome
(ARDS)
renal
impairment
and
neurological
sequelae,
review
highlights
profound
interplay
between
inflammation
dysfunction.
synthesizing
recent
research
clinical
observations,
aims
provide
an
overview
interactions
complications
associated
with
COVID-19,
underscoring
need
for
integrated
approach
treatment
management.
Understanding
these
effects
is
crucial
improving
patient
outcomes
preparing
future
public
health
challenges.
The
persistence
of
symptoms
following
COVID-19
infection
represents
a
significant
challenge
in
healthcare
management.
During
the
outbreak,
tele-rehabilitation
emerged
as
new
tool
to
support
structures
providing
rehabilitation
services.
This
study
assessed
effectiveness
and
feasibility
3-week
home-based
motor
respiratory
program
for
long
individuals
after
traditional
rehabilitation.
Twenty-three
patients
completed
underwent
functional
tests
at
different
time
points
(i.e.
baseline,
hospital
discharge,
tele-rehabilitation).
Motor
function
was
evaluated
using
instrumented
Six-Minutes
Walking
Test
(i6MWT),
with
monitored
heart
rate
oxygen
saturation.
Conversely,
measured
via
forced
vital
capacity
(FVC)
maximal
voluntary
ventilation
(MVV)
tests.
Significant
improvements
(p
&lt;
0.05)
were
observed
throughout
intervention,
including
an
18.3%
increase
walked
distance
from
baseline.
findings
suggest
that
can
enhance
post-COVID
patients.
Despite
limitations
such
sample
size
lack
control
group,
positive
outcomes
seem
proposed
managing
COVID
promoting
recovery.
Further
research
is
needed
validate
these
explore
tele-rehabilitation’s
potential
broader
patient
populations.
