Environmental Science & Technology,
Год журнала:
2024,
Номер
58(47), С. 20873 - 20882
Опубликована: Ноя. 15, 2024
There
is
increasing
evidence
that
particulate
matter
(PM)
pollution
may
adversely
impact
cognition.
Considering
sleep
critical
for
cognitive
health
and
occupies
about
one-third
of
human
life,
understanding
the
effects
indoor
PM
exposure
during
potential
benefits
reducing
such
crucial,
yet
currently
unknown.
This
randomized,
double-blind
crossover
intervention
trial
was
conducted
among
80
college
students
with
real
sham
filtration
in
their
dormitories.
Real-time
levels
nocturnal
parameters
were
monitored,
followed
by
quantification
serum
neurotransmitter
metabolites
assessments
mornings.
We
found
sleep,
particularly
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Март 6, 2024
This
paper
delves
into
the
increasingly
recognized
yet
complex
relationship
between
air
pollution
and
Neurological
Diseases.
Although
detrimental
effects
of
on
respiratory
cardiovascular
health
are
well-documented,
its
impact
neurological
cognitive
disorders
is
an
emerging
area
concern.
In
this
mini
review,
we
explore
intricate
mechanisms
by
which
various
pollutants,
such
as
particulate
matter,
nitrogen
oxides,
polycyclic
aromatic
hydrocarbons,
contribute
to
pathologies.
The
focus
lies
role
oxidative
stress
inflammation
in
exacerbating
conditions
like
Alzheimer's
disease
Parkinson's
disease.
By
unraveling
these
connections,
sheds
light
broader
implications
environmental
factors
underscores
urgent
need
for
policy
interventions
mitigate
pollution's
nervous
system.
Abstract
This
study
presents
a
comprehensive
analysis
of
atmospheric
parameters
in
Nigeria,
utilizing
Sentinel-5P
and
3A/B
offline
datasets
from
April
2018
to
December
2022.
The
research
evaluates
the
concentrations
pollutants
such
as
Nitrogen
Dioxide
(NO
2
),
Sulphur
(SO
Ozone
(O
3
Formaldehyde
(HCHO),
Methane
(CH
4
Carbon
Monoxide
(CO),
Aerosol
Indices
(AI)
across
different
periods.
data
employs
multivariate
techniques,
including
Factor
Analysis,
Pearson
Correlation
Coefficient,
Scatter
Plots,
Dendrogram
Clustering,
providing
insights
into
interrelationships
potential
sources
pollution.
Additionally,
examines
monthly
trends,
temperature
variations,
their
impacts
on
human
health
climate.
findings
reveal
stable
levels
NO
,
SO
O
HCHO
with
minimal
fluctuations,
while
CH
CO
exhibit
slight
possibly
influenced
by
emission
reductions
or
changes.
optical
indices
consistently
indicate
aerosol
presence,
local
emissions
processes.
Multivariate
analyses
highlight
shared
patterns
among
constituents,
shedding
light
common
chemical
relationships.
correlation
coefficients
illustrate
strength
direction
linear
relationships,
offering
valuable
information
pollution
dynamics.
study's
visualizations,
scatter
plots
dendrogram
clustering,
enhance
understanding
complex
interactions.
Overall,
underscores
significance
continuous
monitoring
efforts
for
informed
decision-making
environmental
management
Nigeria.
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Май 24, 2024
Attention
deficit
hyperactivity
disorder
(ADHD),
a
prevalent
neurodevelopmental
in
children,
originates
from
multifaceted
interplay
of
genetic,
neurological,
and
environmental
factors.
Recent
studies
have
increasingly
concentrated
on
determinants,
notably
air
pollution,
their
impact
the
risk
developing
ADHD.
Additionally,
previous
research
has
often
conflated
clinically
diagnosed
ADHD
cases
with
instances
mere
ADHD-like
symptoms,
methodology
that
can
introduce
bias
obscure
true
relationship
between
factors
To
address
this
oversight,
our
systematic
review
meticulously
investigates
both
prenatal
postnatal
exposures
to
particular
pollutants
strictly
Our
comprehensive
encompassed
801
PubMed,
Cochrane
Library,
Web
Science,
Embase
databases,
out
which
eight
met
rigorous
inclusion
criteria.
The
Newcastle-Ottawa
Scale
(NOS)
was
utilized
gauge
quality
bias.
found
substantiated
connection
exposure
PM
2.5
NO
x
heightened
ADHD,
while
10
during
stage
not
associated
These
findings
hint
at
varied
health
impacts
different
particulate
matters
prospect
gender-specific
susceptibilities
such
exposures.
We
also
identified
an
association
,
2
increased
risk,
underlining
potential
harms
early
these
pollutants.
relationships,
seemingly
intricate
potentially
dose-dependent,
underscore
need
for
more
detailed
scrutiny.
unique
value
is
its
exploration
specific
pollution
offer
much-needed
clarity
complex
domain
emphasize
importance
future
standardize
outcome
metrics,
probe
mechanisms,
reduce
heterogeneity.
Abstract
Previous
studies
have
indicated
increased
dementia
risk
associated
with
fine
particulate
matter
(PM
2.5
)
exposure;
however,
the
findings
are
inconsistent.
In
this
systematic
review,
we
assessed
association
between
long-term
PM
exposure
and
outcomes
using
Burden
of
Proof
meta-analytic
framework,
which
relaxes
log-linear
assumptions
to
better
characterize
relative
functions
quantify
unexplained
between-study
heterogeneity
(PROSPERO,
ID
CRD42023421869).
Here
report
a
meta-analysis
28
longitudinal
cohort
published
up
June
2023
that
investigated
outcomes.
We
derived
risk–outcome
scores
(ROSs),
highly
conservative
measures
effect
size
evidence
strength,
mapped
onto
1–5-star
rating
from
‘weak
and/or
inconsistent
evidence’
‘very
strong
consistent
evidence’.
identified
significant
nonlinear
relationship
dementia,
minimum
14%
averaged
across
levels
4.5
26.9
µg
m
−3
(the
15th
85th
percentile
range
included
studies),
reference
2.0
(
n
=
49,
ROS
0.13,
two
stars).
found
Alzheimer’s
disease
12,
0.32,
three
stars)
but
not
vascular
dementia.
Our
highlight
potential
impact
air
pollution
on
brain
aging.
Cities & Health,
Год журнала:
2024,
Номер
8(6), С. 1153 - 1175
Опубликована: Апрель 15, 2024
Global
urbanisation
has
occurred
in
tandem
with
population
ageing,
having
implications
on
human
cognitive
health.
Urban
environmental
factors
such
as
air
pollution
are
known
risk
of
impairment
and
neurodegenerative
disease.
However,
due
to
the
sparse
evidence
base,
biological
pathways
by
which
urban
operate
not
well
understood.
The
aim
this
review
is
explain
how
exploring
epigenome
(i.e.
chemical
modifications
genome
do
change
underlying
gene
sequence)
can
further
our
understanding
these
pathways.
influenced
for
Utilising
complex
epigenetic
analytical
techniques
including
clocks,
Mendelian
randomization
multi-omic
approaches,
it
possible
identify
consequences
biology.
Through
better
modifications,
be
inherited
or
dynamically
response
exposures,
impact
outcomes,
we
work
encourage
development
public
health
policies,
planning
design
policies
reduce
burden
disease
healthier
ageing
older
adult
population.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 6116 - 6116
Опубликована: Июнь 1, 2024
Urban
air
pollution,
a
significant
environmental
hazard,
is
linked
to
adverse
health
outcomes
and
increased
mortality
across
various
diseases.
This
study
investigates
the
neurotoxic
effects
of
particulate
matter
(PM),
specifically
PM2.5
PM10,
by
examining
their
role
in
inducing
oxidative
stress
subsequent
neuronal
cell
death.
We
highlight
novel
finding
that
PM
increases
mitochondrial
ROS
production
via
stimulating
NOX4
activity,
not
through
its
expression
level
Neuro-2A
cells.
Additionally,
PMs
provoke
increasing
activity
NOX2
SH-SY5Y
human
neuroblastoma
cells,
implying
differential
regulation
NOX
proteins.
increase
triggers
opening
permeability
transition
pore
(mPTP),
leading
apoptosis
key
mediators,
including
caspase3,
BAX,
Bcl2.
Notably,
voltage-dependent
anion-selective
channel
1
(VDAC1)
at
µg/mL
PM2.5,
while
PM10
an
from
10
µg/mL.
At
same
concentration
(100
µg/mL),
causes
1.4
times
higher
2.4
than
PM10.
The
cytotoxic
induced
were
alleviated
inhibitors
GKT137831
Apocynin.
In
both
types
levels,
death,
which
Apocynin
rescues.
Variability
NADPH
oxidase
sources
underscores
complexity
PM-induced
neurotoxicity.
Our
findings
NOX4-driven
dysfunction,
suggesting
potential
therapeutic
approach
for
mitigating
