Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 290, С. 117549 - 117549
Опубликована: Дек. 18, 2024
Язык: Английский
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(7), С. 3314 - 3324
Опубликована: Фев. 8, 2024
Fusarium species produce a secondary metabolite known as T-2 toxin, which is the primary and most harmful toxin found in type A trichothecenes. widely food grain-based animal feed endangers health of both humans animals. exposure animals occurs primarily through administration; therefore, first organ that targets gut. In this overview, research progress, toxicity mechanism, detoxification were reviewed, future directions proposed. damages intestinal mucosa destroys structure barrier function; furthermore, disrupts microbiota, causes flora disorders, affects normal metabolic function, kills epidermal cells by inducing oxidative stress, inflammatory responses, apoptosis. The mechanism intestine stress. Currently, selenium plant extracts are mainly used to exert antioxidant effects alleviate enterotoxicity toxin. studies, use genomic techniques find upstream signaling molecules associated with enterotoxin will provide new ideas for prevention toxicity. purpose paper review progress on propose treatment
Язык: Английский
Процитировано
18
Journal of Nutrition, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 25, 2025
Citrinin (CTN) is commonly found in animal feed and stored grains poses a serious threat to human health. Formation of the IP3R1–GRP75–VDAC1 complex has been shown play key role intestinal defense against harmful stimuli, but mechanism its action CTN-exposure-induced enterotoxicity not clear. Therefore, aim this study was investigate IPEC-J2 monolayer cell damage mice. It that CTN exposure triggered pyroptosis increased formation as well mitochondrial levels calcium ions reactive oxygen species (mtROS). And mtROS considered be factor cellular pyroptosis. removal by using Mito-Tempo attenuate failed ion overload. However, silencing GRP75 alleviated increases level mtROS, ions, subsequent confirms induces juxtaposition tissues points out oxidative stress mediated which triggers
Язык: Английский
Процитировано
0
Antioxidants, Год журнала: 2024, Номер 13(1), С. 121 - 121
Опубликована: Янв. 18, 2024
Deoxynivalenol (DON) is the one of most common mycotoxins, widely detected in various original foods and processed foods. Tanshinone IIA (Tan IIA) a fat-soluble diterpene quinone extracted from Salvia miltiorrhiza Bunge, which has multi-biological functions pharmacological effects. However, whether Tan protective effect against DON-induced intestinal toxicity unknown. In this study, results showed treatment could attenuate IPEC-J2 cell death. DON increased oxidation product accumulation, decreased antioxidant ability disrupted barrier function, while reversed function impairment oxidative stress. Furthermore, dramatically improved mitochondrial via quality control. upregulate biogenesis fusion as well downregulate fission unfolded protein response. addition, significantly attenuated mitophagy caused by DON. Collectively, presented potential underlying mechanisms were involved control–mediated mitophagy.
Язык: Английский
Процитировано
3
Veterinary Sciences, Год журнала: 2024, Номер 11(7), С. 291 - 291
Опубликована: Июнь 28, 2024
Mycotoxins are secondary metabolites produced by several fungi and moulds that exert toxicological effects on animals including immunotoxicity, genotoxicity, hepatotoxicity, teratogenicity, neurotoxicity. However, the mechanisms of mycotoxins complex unclear. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin containing 3 (NLRP3) inflammasome is a multimeric cytosolic protein composed NLRP3 sensor, ASC adapter protein, caspase-1 effector. Activation plays crucial role in innate immune defence homeostatic maintenance. Recent studies have revealed activation linked to tissue damage inflammation induced mycotoxin exposure. Thus, this review summarises latest advancements research roles pathogenesis exposure multiple mycotoxins, deoxynivalenol, aflatoxin B1, zearalenone, T-2 toxin, ochratoxin A, fumonisim pyroptosis-related factors inflammation-related vitro vivo pharmacological inhibition specific nonspecific inhibitors summarized examined. This comprehensive contributes better understanding toxicity provides novel insights for pharmacologically targeting as anti-inflammatory agent against
Язык: Английский
Процитировано
2
Опубликована: Янв. 1, 2024
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Язык: Английский
Процитировано
0
Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 279, С. 116483 - 116483
Опубликована: Май 23, 2024
Oxidative stress and inflammation play a fundamental role in the beginning advancement of silicosis. Hence, questing active phytocompounds (APCs) with anti-oxidative anti-inflammatory properties such as diosgenin (DG) emodin (ED) can be therapeutic intervention targeting silica-induced pulmonary fibrosis. Hydrophobicity low bioavailability are barriers that restrict efficacy DG ED against defects. Encapsulating these APCs polymeric nanoparticles overcome this limitation. The present study has thus explored anti-fibrotic effects polylactic-co-glycolic acid (PLGA) (NPs) individually loaded (DGn) or (EDn) combine DG+ED [(DG+ED)n] respirable silica dust (RSD)-induced fibrosis silicosis rat model. Our found individual combined NPs revealed physiochemical characteristics appropriate for IV administration sustained-drug release purposes. Physiological evaluations RSD-induced rats suggested no treatment could improve body weight. Still, they reduced lung coefficient by maintaining moisture. Only (DG+ED)n significantly cleared free silica. All interventions were to attribute increased per cent cell viability BALF, reduce cytotoxicity via minimizing LDH levels, balance oxidant-antioxidant status silicotic rats. expression inflammatory cytokines (TNF-α, IL-1β, IL-6, MCP-1, TGF-β1) efficiently down-regulated compared pure (DG+ED) treatment. drug treatments declined, 8-HdG HYP productions indicate oxidative DNA damage collagen deposition successfully repaired. Moreover, histopathological investigations proposed drugs decrease alveolitis grades However, inhibited In conclusion, RSD induce rats, producing reactive oxygen species (ROS)-mediated cells leading development. NP suppressed formation effectively interrupting fibrosis-silicosis progression. These results may attributed improved through their nano-encapsulation-mediated targeted delivery.
Язык: Английский
Процитировано
0
Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 290, С. 117530 - 117530
Опубликована: Дек. 13, 2024
Язык: Английский
Процитировано
0
Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 290, С. 117549 - 117549
Опубликована: Дек. 18, 2024
Язык: Английский
Процитировано
0