Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 295, С. 118129 - 118129
Опубликована: Апрель 1, 2025
Exposure to benzo[a]pyrene (BaP) could lead the development of lung cancer, but potential mechanisms are complex and remain largely unclear. Plasma tRNA-derived small RNA (tsRNA), a new type epigenetic biomarker might link environment exposure with cancer. Based on this case-control study 272 participants recruited from China, we aim reveal plasma tsRNA signature cancer their mediation effects BaP-induced We sequenced profiles detected adducts Benzo[a]pyrene diol epoxide-albumin (BPDE-Alb) in samples. applied linear regression models estimate associations between BPDE-Alb, normalized risk used analysis explore roles tsRNAs BaP-associated identified 104 significantly related (Bonferroni adjusted P < 0.05). Among these tsRNAs, 17 were expressed at different concentrations before after surgery groups |fold change| > 2 Bonferroni 0.05. In addition, BPDE-Alb associated 5'-M-tRNA-Glu-CTC-1-1-L36, i-M-tRNA-Met-CAT-1-1-L24_pos29 i-M-tRNA-Ala-AGC-2-2-L16_pos16, which mediate separate 40.8 %, 39.1 % 36.8 association BaP Our potentially mediating development, revealed as promising biomarkers
Язык: Английский
Процитировано
0
Energy & Fuels, Год журнала: 2024, Номер 38(22), С. 21735 - 21792
Опубликована: Ноя. 1, 2024
Polycyclic aromatic hydrocarbons (PAHs) are formed invariably through oxidative and pyrolytic degradation of organic materials fuels. Understanding the highly complex reaction mechanisms that dictate their synthesis in thermal systems has been given a great deal focus. Such interest stems from two broad perspectives, namely, enhancing efficiency combustion system, energy recovery fuels protecting environment. Health environmental effects widely vary among PAHs where certain compounds exhibit carcinogenic tendencies. This critical review mainly aims to provide general mechanistic view commonly discussed formation pathways PAHs. The attained knowledge often incorporates experimental measurements kinetic modelings, as well mapped out by quantum chemical calculations. A sampling species is typically conducted via molecular beam (MB)–mass spectroscopy (MS) technique connected reactor (flow reactor, jet-stirred or shock tube). Generally, PAH precursors encompass four categories (radicals molecules): acetylenic compounds, alkyl radicals, phenyl resonance-stabilized cyclic radicals. Overall, relevance mechanism depends on consistency between proposed model pathways, profiles products at investigated conditions (i.e., temperatures, pressures, distance burners). effect seeding common precursors, with other explored surveying pertinent studies. Growth higher PAHs, including toxic pyrene, most likely involves hydrogen abstraction acetylene addition (HACA)-like starting anthracene bimolecular reactions involve benzyl radicals indene molecules. synergistic collaboration different suggested account for observed fast growth rate As experimentally shown, sequential mass 15 u, 24 26 74 indicate routes MAC, HACA, HAVA*, PAC routes, respectively. Whether physical process initial step conversion into soot (the inception step) still debated literature. Recent evidence underscores commence creating dimers clustering under real flame 400–1200 K). Formation synthetic natural polymers ensues condensation fragments structural arrangements polymeric entities, prior fragmentation. surveyed presented this will be useful readers who aim comprehend chemistry underlying systems.
Язык: Английский
Процитировано
3
American Journal of Men s Health, Год журнала: 2024, Номер 18(3)
Опубликована: Май 1, 2024
The aim of this study was to investigate the potential mechanism through which Yishen Tongluo decoction (YSTL) repairs DNA damage caused by benzo(a)pyrene diol epoxide (BPDE) in mouse spermatocytes (GC-2). GC-2 cells were divided randomly into control group, BPDE and low-, medium-, high-dose YSTL groups decoction. A comet assay used detect fragment index (DFI) each group. Based on DFI results, whole transcriptome sequencing conducted, followed trend analysis, gene ontology (GO) enrichment kyoto encyclopedia genes genomes (KEGG) ceRNA network analysis. Compared with group reported a significant increase fragmentation (
Язык: Английский
Процитировано
1
American Journal of Cancer Research, Год журнала: 2024, Номер 14(8), С. 3789 - 3799
Опубликована: Янв. 1, 2024
This study investigated the role of urinary exosomal miR-664a-5p as a potential therapeutic target in prostate cancer (PCa). Small RNA sequencing exosomes from PCa patients with different responses to PARP inhibitors revealed that was significantly upregulated responsive patients. Overexpression enhanced sensitivity cells by directly targeting FOXM1, transcription factor involved DNA damage repair, leading downregulation response genes. Combined treatment and olaparib synergistically inhibited tumor growth PC-3 xenograft mouse model. These findings suggest is biomarker for inhibitor patients, FOXM1 via represents promising strategy enhancing efficacy treatment.
Язык: Английский
Процитировано
1
Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0