Lactobacillus reuteri alleviates diquat induced hepatic impairment and mitochondrial dysfunction via activation of the Nrf2 antioxidant system and suppression of NF-κB inflammatory response DOI Creative Commons

Shenao Zhan,

Lianchi Wu,

Yujie Lv

и другие.

Poultry Science, Год журнала: 2025, Номер 104(5), С. 104997 - 104997

Опубликована: Март 6, 2025

Accumulating evidence has shown that elevated oxidative stress and inflammatory response leads to hepatic impairment dysfunction of hens during the aging process. This study was conducted investigate potential regulatory mechanisms Lactobacillus reuteri (L. reuteri) in alleviating induced by diquat (DQ) exposure. A total 480 48-wk-old Jingbai were randomly assigned 4 groups: control group (Con), L. (L.R), diquat-challenged (DQ), protective (L.R+DQ). The results demonstrated DQ exposure damages lipid metabolism disorders manifested as alanine aminotransferase (ALT) aspartate (AST) activities, triglyceride (TC) contents serum accumulation liver. supplementation alleviated DQ-induced liver injury, reflected repairing morphology decreasing AST ALT activities serum. decreased malonaldehyde (MDA) enhanced antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) through regulating nuclear factor erythroid 2-related 2 (Nrf2) hemeoxygenase-1 (HO-1) mediated system. In addition, curtailed reactive oxygen species (ROS) production mitigated depletion membrane thus recovering mitochondrial function disturbed challenge. Moreover, inhibited toll-like receptor (TLR4)/myeloid differentiation 88 (MyD88)/nuclear factor-kappa B (NF-κB) pathway activation, downregulated pro-inflammatory-response-related gene expressions (IL-1β, TNF-α, IL-6) phosphorylation levels IκBα, p65 reducing apoptosis. Overall, findings indicate provides significant protection against stress, impairment, apoptosis caused laying hens, highlight its a therapeutic probiotic for prolong health poultry.

Язык: Английский

Probiotic Limosilactobacillus reuteri DSM 17938 Alleviates Acute Liver Injury by Activating the AMPK Signaling via Gut Microbiota–Derived Propionate DOI
Yuting Zhao,

Weiqi Xie,

Jingyi Duan

и другие.

Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Язык: Английский

Процитировано

1
Lactiplantibacillus plantarum JM113 alleviates mitochondrial dysfunction induced by deoxynivalenol in the jejunum of broiler chickens DOI Creative Commons

Haonan Tong,

Saisai Liang,

Xinying Lv

и другие.

Poultry Science, Год журнала: 2025, Номер 104(4), С. 104948 - 104948

Опубликована: Фев. 24, 2025

Язык: Английский

Процитировано

1
Lactobacillus reuteri alleviates diquat induced hepatic impairment and mitochondrial dysfunction via activation of the Nrf2 antioxidant system and suppression of NF-κB inflammatory response DOI Creative Commons

Shenao Zhan,

Lianchi Wu,

Yujie Lv

и другие.

Poultry Science, Год журнала: 2025, Номер 104(5), С. 104997 - 104997

Опубликована: Март 6, 2025

Accumulating evidence has shown that elevated oxidative stress and inflammatory response leads to hepatic impairment dysfunction of hens during the aging process. This study was conducted investigate potential regulatory mechanisms Lactobacillus reuteri (L. reuteri) in alleviating induced by diquat (DQ) exposure. A total 480 48-wk-old Jingbai were randomly assigned 4 groups: control group (Con), L. (L.R), diquat-challenged (DQ), protective (L.R+DQ). The results demonstrated DQ exposure damages lipid metabolism disorders manifested as alanine aminotransferase (ALT) aspartate (AST) activities, triglyceride (TC) contents serum accumulation liver. supplementation alleviated DQ-induced liver injury, reflected repairing morphology decreasing AST ALT activities serum. decreased malonaldehyde (MDA) enhanced antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) through regulating nuclear factor erythroid 2-related 2 (Nrf2) hemeoxygenase-1 (HO-1) mediated system. In addition, curtailed reactive oxygen species (ROS) production mitigated depletion membrane thus recovering mitochondrial function disturbed challenge. Moreover, inhibited toll-like receptor (TLR4)/myeloid differentiation 88 (MyD88)/nuclear factor-kappa B (NF-κB) pathway activation, downregulated pro-inflammatory-response-related gene expressions (IL-1β, TNF-α, IL-6) phosphorylation levels IκBα, p65 reducing apoptosis. Overall, findings indicate provides significant protection against stress, impairment, apoptosis caused laying hens, highlight its a therapeutic probiotic for prolong health poultry.

Язык: Английский

Процитировано

1