Microplastics and Nanoplastics Increase Major Adverse Cardiac Events in Patients with Myocardial Infarction
Journal of Hazardous Materials,
Год журнала:
2025,
Номер
489, С. 137624 - 137624
Опубликована: Фев. 19, 2025
Microplastics
and
nanoplastics
(MNPs)
have
implicated
in
cardiovascular
disease
preclinical
studies.
Our
objective
is
to
investigate
the
relationship
between
MNPs
coronary
arteries
major
adverse
cardiac
events
(MACE)
patients
with
myocardial
infarction
(MI).We
conducted
a
prospective
observational
study
involving
undergoing
angiography
for
MI.
Coronary
blood
samples
were
analyzed
presence
of
using
pyrolysis-gas
chromatography-mass
spectrometry.
A
total
142
enrolled,
110
completing
31.5-month
follow-up.
Among
them,
48
(43.6
%)
had
detectable
polystyrene,
79
(71.8
polyethylene,
105
(95.4
polyvinyl
chloride
(PVC),
68
(61.8
polyamide
66
their
blood.
PVC
concentration
was
higher
who
experienced
MACE.
Furthermore,
levels
positively
associated
proinflammatory
factors
(IL-1β,
IL-6,
IL-18,
TNF-α),
odds
MACE
(OR:
1.090,
95
%CI:
1.032-1.1523,
P
=
0.002).
Notably,
each
10-unit
increase
PVC,
there
1.374-fold
risk
(OR=2.374,
1.366-4.128,
Additionally,
we
collected
thrombus
from
an
additional
21
MI
patients,
finding
that
thrombi
correlated
inflammatory
markers
monocyte/macrophage
infiltration.
Язык: Английский
The links between soil and water pollution and cardiovascular disease
Atherosclerosis,
Год журнала:
2025,
Номер
unknown, С. 119160 - 119160
Опубликована: Март 1, 2025
Soil
and
water
pollution
represent
significant
threats
to
global
health,
ecosystems,
biodiversity.
Healthy
soils
underpin
terrestrial
supporting
food
production,
biodiversity,
retention,
carbon
sequestration.
However,
soil
degradation
jeopardizes
the
health
of
3.2
billion
people,
while
over
2
live
in
water-stressed
regions.
Pollution
soil,
air,
is
a
leading
environmental
cause
disease,
contributing
9
million
premature
deaths
annually.
contamination
stems
from
heavy
metals,
synthetic
chemicals,
pesticides,
plastics,
driven
by
industrial
activity,
agriculture,
waste
mismanagement.
These
pollutants
induce
oxidative
stress,
inflammation,
hormonal
disruption,
significantly
increasing
risks
for
non-communicable
diseases
(NCDs)
such
as
cardiovascular
disease
(CVD).
Emerging
contaminants
like
micro-
nanoplastics
amplify
through
cellular
damage,
dysfunction.
Urbanization
climate
change
exacerbate
deforestation,
overfertilization,
pollution,
further
threatening
ecosystem
sustainability
human
health.
Mitigation
efforts,
reducing
chemical
exposure,
adopting
sustainable
land-use
practices,
advancing
urban
planning,
have
shown
promise
lowering
pollution-related
impacts.
Public
initiatives,
stricter
controls,
lifestyle
interventions,
including
antioxidant-rich
diets,
can
also
mitigate
risks.
remains
preventable,
demonstrated
high-income
nations
implementing
cost-effective
solutions.
Policies
European
Commission's
Zero-Pollution
Vision
aim
reduce
safe
levels
2050,
promoting
ecosystems
public
Addressing
critical
combating
burden
NCDs,
particularly
CVDs,
fostering
healthier
environment
future
generations.
Язык: Английский
Polystyrene bead ingestion promotes atherosclerosis plaque progression via BMP signaling in mice
Food and Chemical Toxicology,
Год журнала:
2025,
Номер
unknown, С. 115455 - 115455
Опубликована: Май 1, 2025
Язык: Английский
Behavioral and molecular effects of micro and nanoplastics across three plastic types in fish: weathered microfibers induce a similar response to nanosized particles
Frontiers in Toxicology,
Год журнала:
2024,
Номер
6
Опубликована: Ноя. 26, 2024
Micro
and
nanoplastics
(MNPs)
are
ubiquitous
in
the
environment
have
been
detected
most
ecosystems,
including
remote
regions.
The
class
of
contaminants
under
MNP
umbrella
is
quite
broad
encompasses
variable
polymer
types,
shapes,
sizes.
Fibers
frequently
environment,
followed
by
fragments,
but
still
represent
only
a
small
fraction
laboratory
studies.
Many
toxicity
studies
done
using
polystyrene
microbeads
which
neither
nor
shape
present
environment.
Additionally,
these
virgin
particles
when
majority
pollution
from
secondary
microplastics
weathered
broken
down
over
time.
To
address
data
gaps,
we
exposed
model
fish
Inland
Silverside,
Язык: Английский