Primary astrocytes as a cellular depot of polystyrene nanoparticles
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 22, 2025
Abstract
The
continuous
increase
in
plastic
production
has
resulted
increased
generation
of
microplastic
particles
(MPs),
and
nanoplastic
(NPs).
Recent
evidence
suggests
that
nanoplastics
may
be
a
potent
neurotoxin
because
they
are
able
to
freely
cross
the
blood–brain
barrier
enter
brain.
Therefore,
cytotoxic
effects
polystyrene
nanoparticles
(PS-NPs)
on
cellular
systems
cerebral
origin
should
thoroughly
investigated.
aim
current
study
is
evaluate
potential
25
nm
PS-NPs
vitro
cultured
cells
such
as
primary
astrocytes,
neurons
their
co-cultures
established
from
cortex
Wistar
pups.
results
show
internalized
both
inducing
time-
concentration-dependent
effects.
However,
quantification
fluorescence
intensity
indicates
cell
type-dependent
differences
efficiency
uptake.
Astrocytes
several
times
more
efficient
at
accumulating
than
neurons,
this
phagocytosis-dependent
process.
Moreover,
high
rate
internalization
during
prolonged
exposure
(72
h)
promotes
astroglial
activation,
assessed
by
analysis
GFAP
expression
immunocytochemical
imaging.
astroglia
act
depot
protect
neurons.
once
critical
threshold
exceeded,
become
overactivated
can
lose
protective
functions.
These
highlight
importance
further
research
mechanisms
underlying
nanoplastic-induced
toxicity,
which
have
implications
for
understanding
broader
impact
pollution
neurological
Язык: Английский
Polystyrene nanoparticles induce DNA damage and apoptosis in HeLa cells
Heliyon,
Год журнала:
2024,
Номер
11(1), С. e41298 - e41298
Опубликована: Дек. 18, 2024
Язык: Английский
Microplastic and Extracellular Vesicle Interactions: Recent Studies on Human Health and Environment Risks
Biophysica,
Год журнала:
2024,
Номер
4(4), С. 724 - 746
Опубликована: Дек. 21, 2024
Microplastics
(MPs)
are
widespread
environmental
pollutants
that
have
drawn
significant
attention
due
to
their
possible
health
risks
humans
and
animals,
as
well
extensive
presence
in
ecosystems.
Recent
growing
evidence
highlights
a
remarkable
relationship
between
MPs
extracellular
vesicles
(EVs),
nanoscale
particles
involved
intercellular
communication.
The
purpose
of
this
review
was
investigate
how
the
relationships
EVs
can
affect
cellular
functions
interaction
could
impact
conditions
leading
broader
ecological
risks.
patterns
bioactivity
both
strongly
influenced
by
biophysical
characteristics
such
hydrophobicity,
surface
charge,
particle
size,
which
received
particular
from
scientific
community.
studies
indicate
EV
distribution
capacity
function
appropriately
biological
systems.
Additionally,
modify
molecular
cargo
EVs,
may
result
alterations
cell
signaling
pathways.
Understanding
interactions
provide
important
opportunities
comprehend
potential
effects
on
human
systems,
especially
when
it
comes
cancer
development,
endocrine,
metabolic,
inflammatory
disorders,
disruptions.
This
emphasizes
necessity
multidisciplinary
research
clarify
mechanisms
regulating
EVs.
Язык: Английский