Angelicae Pubescentis Radix Remitted Intestine Damage in Mice Induced by Escherichia coli via Mediating Antioxidant Defense, Inflammatory Mediators, and Restoring Gut Microbiota DOI Creative Commons

Kejun Deng,

Xu Chang,

Qing He

и другие.

Veterinary Sciences, Год журнала: 2025, Номер 12(4), С. 354 - 354

Опубликована: Апрель 10, 2025

This study aims to explore the therapeutic potential of Angelicae Pubescentis Radix (APR), a traditional Chinese medicine that is widely known for its anti-inflammatory, anti-oxidative, and anti-microbial properties, using mouse model. In this study, 30 mice were selected divided into three groups: control group (CD), infection (ED), treatment (TD). Mice in TD gavaged with APR oil (0.15 mL/kg/day) 20 days, while CD ED received an equal volume normal saline. On 21st day, infected multi-drug-resistant E. coli (1 × 107 CFU/mL) derived from diarrheal yak. Twenty-four hours later, all euthanized, blood, organs, intestinal samples collected analysis. The results sections bacterial load revealed significantly reduced (p < 0.05) both injury. Serum analysis indicated also alleviated inflammation oxidative stress induced by infection. Intestinal microbiota sequencing further showed increased abundance probiotics such as Ligilactobacillus, Paludicola, Blautia_A_1417806 enhancing enrichment functional pathways associated antioxidant defense. conclusion, effectively alleviates diseases caused infection, promotes growth beneficial bacteria, improves capacity animals. Additionally, these findings confirm APR’s role addressing immediate effects rather than chronic adaptations. Future studies should investigate prolonged beyond acute phase.

Язык: Английский

Angelicae Pubescentis Radix Remitted Intestine Damage in Mice Induced by Escherichia coli via Mediating Antioxidant Defense, Inflammatory Mediators, and Restoring Gut Microbiota DOI Creative Commons

Kejun Deng,

Xu Chang,

Qing He

и другие.

Veterinary Sciences, Год журнала: 2025, Номер 12(4), С. 354 - 354

Опубликована: Апрель 10, 2025

This study aims to explore the therapeutic potential of Angelicae Pubescentis Radix (APR), a traditional Chinese medicine that is widely known for its anti-inflammatory, anti-oxidative, and anti-microbial properties, using mouse model. In this study, 30 mice were selected divided into three groups: control group (CD), infection (ED), treatment (TD). Mice in TD gavaged with APR oil (0.15 mL/kg/day) 20 days, while CD ED received an equal volume normal saline. On 21st day, infected multi-drug-resistant E. coli (1 × 107 CFU/mL) derived from diarrheal yak. Twenty-four hours later, all euthanized, blood, organs, intestinal samples collected analysis. The results sections bacterial load revealed significantly reduced (p < 0.05) both injury. Serum analysis indicated also alleviated inflammation oxidative stress induced by infection. Intestinal microbiota sequencing further showed increased abundance probiotics such as Ligilactobacillus, Paludicola, Blautia_A_1417806 enhancing enrichment functional pathways associated antioxidant defense. conclusion, effectively alleviates diseases caused infection, promotes growth beneficial bacteria, improves capacity animals. Additionally, these findings confirm APR’s role addressing immediate effects rather than chronic adaptations. Future studies should investigate prolonged beyond acute phase.

Язык: Английский

Процитировано

0