Interaction of high temperature and NO2 exposure on asthma risk: In vivo experimental evidence of inflammation and oxidative stress

The Science of The Total Environment, Год журнала: 2023, Номер 869, С. 161760 - 161760

Опубликована: Янв. 23, 2023

Язык: Английский

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Melatonin alleviates T-2 toxin-induced oxidative damage, inflammatory response, and apoptosis in piglet spleen and thymus

International Immunopharmacology, Год журнала: 2024, Номер 129, С. 111653 - 111653

Опубликована: Фев. 13, 2024

Язык: Английский

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Low-dose deoxynivalenol exposure inhibits hepatic mitophagy and hesperidin reverses this phenomenon by activating SIRT1

Journal of Hazardous Materials, Год журнала: 2024, Номер 468, С. 133854 - 133854

Опубликована: Фев. 22, 2024

Язык: Английский

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Indoor metabolites and chemicals outperform microbiome in classifying childhood asthma and allergic rhinitis

Eco-Environment & Health, Год журнала: 2023, Номер 2(4), С. 208 - 218

Опубликована: Авг. 22, 2023

Indoor microorganisms impact asthma and allergic rhinitis (AR), but the associated microbial taxa often vary extensively due to climate geographical variations. To provide more consistent environmental assessments, new perspectives on exposure for AR are needed. Home dust from 97 cases (32 alone, 37 28 comorbidity) 52 age- gender-matched controls in Shanghai, China, were analyzed using high-throughput shotgun metagenomic sequencing liquid chromatography-mass spectrometry. Homes of healthy children enriched with microbes, including Paracoccus, Pseudomonas, Psychrobacter, metabolites like keto acids, indoles, pyridines, flavonoids (astragalin, hesperidin) (False Discovery Rate < 0.05). A neural network co-occurrence probability analysis revealed that involved producing these pyridines. Conversely, homes diseased mycotoxins synthetic chemicals, herbicides, insecticides, food/cosmetic additives. Using a random forest model, characteristic Shanghai used classify high low prevalence asthma/AR an independent dataset Malaysian schools (N = 1,290). achieved average accuracy 74.9% 77.1% differentiating AR, respectively, whereas indoor only 51.0% 59.5%, respectively. These results suggest chemicals rather than microbiome potentially superior indicators childhood AR. This study extends traditional risk assessment focusing allergens or air pollutants thereby revealing potential novel intervention strategies diseases.

Язык: Английский

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Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics study

World Allergy Organization Journal, Год журнала: 2025, Номер 18(1), С. 101017 - 101017

Опубликована: Янв. 1, 2025

Язык: Английский

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Indoor Airborne Microbiome and Endotoxin: Meteorological Events and Occupant Characteristics Are Important Determinants

Environmental Science & Technology, Год журнала: 2023, Номер 57(32), С. 11750 - 11766

Опубликована: Июль 31, 2023

Airborne bacteria and endotoxin may affect asthma allergies. However, there is limited understanding of the environmental determinants that influence them. This study investigated airborne microbiomes in homes 1038 participants from five cities Northern Europe: Aarhus, Bergen, Reykjavik, Tartu, Uppsala. dust particles were sampled with electrostatic fall collectors (EDCs) participants' bedrooms. The washed EDCs' clothes was used to extract DNA endotoxin. extracts for quantitative polymerase chain (qPCR) measurement 16S rRNA gene sequencing, while measured using kinetic chromogenic limulus amoebocyte lysate (LAL) assay. results showed households Tartu Aarhus had a higher bacterial load diversity than those Bergen possibly due elevated concentrations outdoor taxa associated low precipitation high wind speeds. Bergen-Tartu highest difference (ANOSIM

Язык: Английский

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Environmental determinants and demographic influences on global urban microbiomes, antimicrobial resistance and pathogenicity

npj Biofilms and Microbiomes, Год журнала: 2023, Номер 9(1)

Опубликована: Дек. 7, 2023

Abstract Urban microbiome plays crucial roles in human health and are related to various diseases. The MetaSUB Consortium has conducted the most comprehensive global survey of urban microbiomes date, profiling microbial taxa/functional genes across 60 cities worldwide. However, influence environmental/demographic factors on remains be elucidated. We collected 35 environmental demographic characteristics examine their effects diversity/composition by PERMANOVA regression models. PM 10 concentration was primary determinant factor positively associated with α-diversity (observed species: p = 0.004, β 1.66, R 2 0.46; Fisher’s alpha: 0.005, 0.68, 0.43), whereas GDP per capita negatively 0.046, −0.70, 0.10; −0.34, 0.22). β-diversity shaped seven characteristics, including Köppen climate type, vegetation greenness fraction, soil 2.5 concentration, annual average precipitation temperature (PERMANOVA, < 0.001, 0.01–0.06), cumulatively accounted for 20.3% community variance. Canonical correspondence analysis (CCA) identified species strongly characteristic variation. Cities East Asia higher showed an increased abundance Corynebacterium metruchotii , America a fraction exhibited casei . prevalence antimicrobial resistance (AMR) were solar radiation ( 0.005). Total pathogens population June 0.05). Our study presents first microbiome. findings indicate that managing air quality is essential regulating diversity composition. Meanwhile, socio-economic considerations, particularly reducing antibiotic usage regions lower GDP, paramount curbing spread environments.

Язык: Английский

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Preconceptional, pregnant, and postnatal exposure to outdoor air pollution and indoor environmental factors: Effects on childhood parasitic infections

The Science of The Total Environment, Год журнала: 2023, Номер 912, С. 169234 - 169234

Опубликована: Дек. 14, 2023

Язык: Английский

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Impact of environmental characteristics on children's gut microbiota – A pilot study in assessing the role of indoor microbiome and metabolites

Environmental Research, Год журнала: 2023, Номер 234, С. 116114 - 116114

Опубликована: Май 18, 2023

Язык: Английский

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The Role of Indoor Microbiome and Metabolites in Shaping Children’s Nasal and Oral Microbiota: A Pilot Multi-Omic Analysis

Metabolites, Год журнала: 2023, Номер 13(10), С. 1040 - 1040

Опубликована: Сен. 27, 2023

Maintaining a diverse and well-balanced nasal oral microbiota is vital for human health. However, the impact of indoor microbiome metabolites on remains largely unknown. Fifty-six children in Shanghai were surveyed to complete questionnaire about their personal environmental characteristics. The from vacuumed dust profiled via shotgun metagenomics untargeted liquid chromatography-mass spectrometry (LC–MS). was characterized using full-length 16S rRNA sequencing PacBio. Associations between personal/environmental characteristics nasal/oral calculated PERMANOVA regression analyses. We identified 6247, 431, 342 microbial species dust, nasal, cavities, respectively. overall composition showed significant associations with tobacco smoke (ETS) exposure during pregnancy early childhood (p = 0.005 0.03, respectively), abundance total flavonoids two mycotoxins (deoxynivalenol nivalenol) 0.01, 0.02, respectively). Notably, several flavonoids, such as baicalein, eupatilin, isoliquiritigenin, tangeritin, hesperidin, positive correlations alpha diversity protective taxa cavities < 0.02), suggesting potential beneficial roles promoting Conversely, high carbohydrate/fat food intake ETS diminished microorganisms while augmenting risky cavities. Further, transfer observed environment cavity (Moraxella catarrhalis, Streptococcus mitis, salivarius), which could potentially increase virulence factors related adherence immune modulation vancomycin resistance genes children. This first study reveal association microbiome/metabolites multi-omic approaches. These findings risk environment.

Язык: Английский

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