Exploring the Meandering Pathways of Random Walk: From Finance to Physics, Biology, and Beyond

Highlights in Science Engineering and Technology, Год журнала: 2024, Номер 88, С. 162 - 168

Опубликована: Март 29, 2024

As a matter of fact, the random walk has been implemented in various applications among different fields recent years. With this mind, study explores concept and its modern application three specific fields, i.e., finance, physics biology. Based on an analysis key articles studies, exploration identifies main themes, including efficient market hypothesis, Brownian Motion as well genetic drift patterns. According to analysis, also highlights gaps literature, suggesting need for further empirical research these areas. Understanding intricacies theory is essential science, technology, decision-making, provides valuable insights into evolution current status. Overall, results shed light guiding corresponding subjects.

Язык: Английский

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Glycyrrhiza glabra L. Extracts and Other Therapeutics against SARS-CoV-2 in Central Eurasia: Available but Overlooked

Molecules, Год журнала: 2023, Номер 28(16), С. 6142 - 6142

Опубликована: Авг. 19, 2023

In Central Eurasia, the availability of drugs that are inhibitors SARS-CoV-2 virus and have proven clinical efficacy is still limited. The aim this study was to evaluate activity were available in Kazakhstan during acute phase epidemic against SARS-CoV-2. Antiviral reported for Favipiravir, Tilorone, Cridanimod, which registered used treatment respiratory viral infections Kazakhstan. A licorice (Glycyrrhiza glabra) extract also incorporated into because it offered an opportunity develop plant-derived antivirals. Favipiravir drug, had been advertised local markets as anti-COVID cure, showed no cell cultures. On contrary, Cridanimod impressive high (median inhibitory concentration 66 μg/mL) SARS-CoV-2, justifying further studies trials. despite being same pharmacological group stimulated replication inhibited cultures, with a median effective 16.86 mg/mL. Conclusions: synthetic, low-molecular-weight compound suppresses at notably low concentrations, drug not toxic cells therapeutic concentrations. contrast its role inducer interferons, active genetic defect interferon production, suggesting different mechanism action. attractive inclusion trials and, presumably, other coronaviruses. from shows At time, doses 2 g/kg plant show little or toxicity animal studies; reason, products can be considered development safe, orally administered adjunctive therapy.

Язык: Английский

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Impact of pre-pandemic travel mobility patterns on the spatial diffusion of COVID-19 in South Korea

Journal of Transport & Health, Год журнала: 2022, Номер 26, С. 101479 - 101479

Опубликована: Июль 18, 2022

Язык: Английский

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The illusion of personal health decisions for infectious disease management: disease spread in social contact networks

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Янв. 3, 2023

Abstract Close contacts between individuals provide opportunities for the transmission of diseases, including COVID-19. Individuals take part in many different types interactions, those with classmates, co-workers, and household members; conglomeration all these interactions produces a complex social contact network interconnecting across population. Thus, while an individual might decide their own risk tolerance response to threat infection, consequences such decisions are rarely so confined, propagating far beyond any one person. We asses effect population-level risk-tolerance regimes, population structure form age household-size distributions, on epidemic spread plausible human networks gain insight into how affects pathogen through In particular, we find that changes behaviour vulnerable isolation is insufficient reduce individuals’ infection risk, can have varied counter-acting effects outcomes, that, general, among co-workers greater contribution disease than do children at school. Taken together, results promote nuanced understanding networks, implications public health strategies.

Язык: Английский

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Serological Survey in a university community after the fourth wave of COVID-19 in Senegal

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 30, 2024

Abstract Cross-sectional survey was conducted to assess the true extent of COVID-19 exposure among students and staff Polytechnic High School (PHS). Random cluster sampling carried out between May 19 August 18, 2022, after fourth wave transmission. IgM IgG SARS-CoV-2 antibodies were screened using WANTAI ELISA assays. Seroprevalence descriptive statistics calculated. Moreover, associations seropositivity different factors (age, gender, preventive, etc.) determined logistic regression. A total 637 participants recruited, including 563 students, followed by 52 TAS officers, 22 professors. The median age 21 years [18–63]. 62.0% female, 36.89% male, with a male-to-female ratio = 0.59. overall seroprevalence 92% 6.91% respectively. We found higher in men than women (9.4% vs. 5.6%) lower (18-25) group compared (55-65) years. Low compliance preventive measures significant depending on non-respect social distancing (p 0.008). associated Body Mass Indice (BMI) categorized (O.R. 0.238, p 0.043), ethnic 0.723, 0.046) marital status 2.399, 0.021). vaccination 4.741, < 0.001). Our study revealed that majority have already been exposed SARS-CoV-2, which confirms circulation PHS at time survey. results underline importance seroepidemiological surveys estimate real impact pandemic community monitor disparities antibody response population.

Язык: Английский

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Easing anxiety symptoms through leisure activities during social isolation: Findings from nationally representative samples

PLoS ONE, Год журнала: 2024, Номер 19(6), С. e0303585 - e0303585

Опубликована: Июнь 10, 2024

Public health interventions implemented during the COVID-19 pandemic may exacerbate anxiety symptoms for many. We conducted this study to better understand role of leisure activity in promoting mental wellness times social isolation and reduced access recreation facilities support services. analyzed nationally representative survey data collected by Statistics Canada as part Canadian Perspectives Survey Series (CPSS) May 4–10 (CPSS 2) July 20 26, 2020 4). Data related measured a score more than 10 on General Anxiety Disorder scale were examined using descriptive log-binomial regression analyses. sampling weights applied all analyses, results adjusted sociodemographic characteristics. Exercise communication with friends loved ones most frequently reported activity. Prevalence moderate severe participants was lower CPSS 4 compared 2. Results analyses revealed prevalence those who engaged exercise communication, while meditated exhibited higher prevalence. In conclusion, activities, such ones, can promote wellness. Future research should clarify meditation promotion periods isolation.

Язык: Английский

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Social anxiety disorder and COVID-19: Treatment with cognitive behavioral therapy

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 533 - 543

Опубликована: Янв. 1, 2024

Язык: Английский

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From Node to Network: Weaving A Global Perspective on Efficacy and Costs of Non-Pharmaceutical Interventions

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 31, 2024

Non-pharmaceutical intervention (NPI) policies, ranging from mild to total isolation, were implemented during the COVID-19 pandemic across globe. We adopt a systematic approach guide policymakers in deployment of NPI policies mitigate pandemic's effects while maintaining proper balance on their social and economic impacts. The optimal timings enact end policy depend both strictness transmissibility virus. Our results show that strict is not always most effective disease, other modest NPIs can function better especially when virus highly transmissible. If an only be applied for limited period due constraints, it suboptimal implement at onset.

Язык: Английский

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Serological survey in a university community after the fourth wave of COVID-19 in Senegal

PLoS ONE, Год журнала: 2024, Номер 19(11), С. e0298509 - e0298509

Опубликована: Ноя. 21, 2024

A cross-sectional survey was conducted at Polytechnic High School (PHS) to assess the spread of COVID-19 infection among students and staff. random cluster sampling between May 19 August 18, 2022, after fourth wave in Senegal. IgM IgG SARS-CoV-2 antibodies were screened using WANTAI ELISA assays. Seroprevalence descriptive statistics calculated, associations seropositivity different factors determined logistic regression. total 637 participants recruited median age 21 years [18–63]. 62.0% female, 36.89% male, with a male-to-female ratio = 0.59. The overall seroprevalence 92% 6.91% respectively. Among those who tested positive for IgM, 6.75% also IgG, 0.15% negative IgG. Interestingly, 6.90% both We found higher men than women (9.4% vs. 5.6%) lower (18–25) group compared (55–65) years. revealed significant difference according declared fatigue symptoms [92.06% (95% CI: 89.96–94.16)] did not [80.39% 77.31–83.47)], p 0.0027. be associated Body Mass Index (BMI) categories (O.R. 0.238, 0.043), ethnic 0.723, 0.046), marital status 2.399, 0.021). Additionally, linked vaccination 4.741, < 0.001). Our study that most staff PHS exposed SARS-CoV-2, confirming virus’s circulation time survey. identified differences individual susceptibility need further clarification. results highlight importance seroepidemiological surveys true impact pandemic community monitor variations antibody response.

Язык: Английский

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The illusion of personal health decisions for infectious disease management: disease spread in social contact networks

Royal Society Open Science, Год журнала: 2023, Номер 10(3)

Опубликована: Март 1, 2023

Close contacts between individuals provide opportunities for the transmission of diseases, including COVID-19. While take part in many different types interactions, those with classmates, co-workers and household members, it is conglomeration all these interactions that produces complex social contact network interconnecting across population. Thus, while an individual might decide their own risk tolerance response to a threat infection, consequences such decisions are rarely so confined, propagating far beyond any one person. We assess effect population-level risk-tolerance regimes, population structure form age household-size distributions, interaction on epidemic spread plausible human networks gain insight into how affects pathogen through In particular, we find behavioural changes by vulnerable isolation insufficient reduce individuals’ infection can have varied counteracting effects outcomes. The relative impact each type was contingent assumptions underlying construction, stressing importance empirical validation. Taken together, results promote nuanced understanding disease networks, implications public health strategies.

Язык: Английский

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