Journal of Cancer Prevention,
Год журнала:
2023,
Номер
28(4), С. 143 - 149
Опубликована: Дек. 30, 2023
Cyclic
GMP-AMP
(cGAMP),
synthesized
by
cGAMP
synthase
(cGAS),
serves
as
a
secondary
messenger
that
modulates
various
cellular
processes,
including
cell
proliferation,
death,
immune
response,
and
inflammation.cGAS
is
activated
upon
detecting
cytoplasmic
DNA,
which
may
originate
from
damaged
genomic
mitochondrial
DNA
or
viral
bacterial
infections.The
presence
of
in
the
cytoplasm
can
trigger
substantial
inflammatory
reaction
cytokine
production
via
cGAS-STING
signaling
pathway.Consequently,
specific
inhibitors
targeting
this
pathway
hold
significant
potential
chemopreventive
agents.In
review,
we
explore
effectiveness
modulating
cGAS
activity.We
discuss
role
cGAMP,
mechanism
action
for
distinguishing
between
self
foreign
possible
functions
within
nucleus.
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 13, 2024
This
chapter
reviews
the
basic
principles
of
signal
transduction
and
highlights
its
critical
role
in
drug
discovery
development.
The
begins
by
explaining
concept
cellular
signaling
variety
pathways
that
regulate
processes.
It
examines
key
components
pathways,
including
receptors,
ligands,
intercellular
messengers,
effectors,
emphasizes
their
complex
interplay.
In
addition,
as
targets
for
interventions.
different
classes
such
G
protein-coupled
nuclear
tyrosine
kinase
discusses
activation
downstream
events.
various
mechanisms
action,
agonists,
antagonists,
modulators,
are
also
studied
context
transduction.
importance
pathway
specificity
crosstalk
development
challenges
opportunities
associated
with
pharmacological
modulation
pathways.
addresses
impact
dysregulated
disease,
how
targeted
use
these
can
lead
to
innovative
therapeutic
strategies.
Finally,
studying
both
preclinical
clinical
settings,
emphasizing
need
robust
reliable
tests
assess
efficacy
safety
effective
therapeutics.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12506 - 12506
Опубликована: Ноя. 21, 2024
Radiotherapy
(RT)
has
been
shown
to
be
a
cornerstone
of
both
palliative
and
curative
tumor
care.
RT
generally
reported
sharply
limited
by
ionizing
radiation
(IR)-induced
toxicity,
thereby
constraining
the
control
effect
on
growth.
FLASH-RT
is
delivery
ultra-high
dose
rate
(UHDR)
several
orders
magnitude
higher
than
what
presently
used
in
conventional
(CONV-RT).
The
clinical
trials
have
designed
examine
UHDR
deliverability,
effectiveness
control,
tolerance
normal
tissue,
reproducibility
treatment
effects
across
institutions.
Although
it
still
its
infancy,
potential
rival
current
terms
safety.
Several
studies
suggested
that
adoption
very
limited,
incorporation
this
new
technique
into
routine
will
require
use
accurate
dosimetry
methods
reproducible
equipment
enable
reliable
robust
measurements
doses
rates.
purpose
review
highlight
advantages
technology,
mechanisms
underpinning
effect,
major
challenges
need
tackled
transfer
FLASH-RT.
Journal of Cancer Prevention,
Год журнала:
2023,
Номер
28(4), С. 143 - 149
Опубликована: Дек. 30, 2023
Cyclic
GMP-AMP
(cGAMP),
synthesized
by
cGAMP
synthase
(cGAS),
serves
as
a
secondary
messenger
that
modulates
various
cellular
processes,
including
cell
proliferation,
death,
immune
response,
and
inflammation.cGAS
is
activated
upon
detecting
cytoplasmic
DNA,
which
may
originate
from
damaged
genomic
mitochondrial
DNA
or
viral
bacterial
infections.The
presence
of
in
the
cytoplasm
can
trigger
substantial
inflammatory
reaction
cytokine
production
via
cGAS-STING
signaling
pathway.Consequently,
specific
inhibitors
targeting
this
pathway
hold
significant
potential
chemopreventive
agents.In
review,
we
explore
effectiveness
modulating
cGAS
activity.We
discuss
role
cGAMP,
mechanism
action
for
distinguishing
between
self
foreign
possible
functions
within
nucleus.
