Reverse engineering the Gut-Brain Axis and microbiome-metabolomics for symbiotic/pathogenic balance in neurodegenerative diseases
Gut Microbes,
Год журнала:
2024,
Номер
16(1)
Опубликована: Ноя. 10, 2024
Deciphering
the
molecular
communications
along
gut-brain
axis
can
help
in
understanding
pathophysiology
of
neurodegenerative
diseases
and
exploiting
gut
microbiome
for
therapeutics.
However,
microbes
their
metabolites
have
a
multifaceted
role
mediating
both
brain
physiology
pathology.
There
is
lack
how
when
this
tipped
what
are
those
contributing
factors,
at
local
(gut)
distal
(neuronal)
levels,
that
drive
imbalance.
Here
we
reviewed
its
context
summarized
different
factors
such
as
gut-microbial
diversity,
metabolites,
native
immune
system
integrity
epithelial
blood-brain
barriers
interconnected
collectively
define
involvement
gut-microbiome
pathologies.
It
also
underlines
need
multidisciplinary
tools
animal
models
to
simultaneously
reflect
on
many
these
better
correlate
with
clinical
observations
data
obtained
from
human
biopsies
fecal
samples.
Harnessing
will
herald
paradigm
shift
medicine
aging,
emphasizing
significance
broader
spectrum
health
disease.
Язык: Английский
Exercise-induced adaptations in the kynurenine pathway: implications for health and disease management
Frontiers in Sports and Active Living,
Год журнала:
2025,
Номер
7
Опубликована: Март 6, 2025
Background
Tryptophan
(TRP)
metabolism
through
the
kynurenine
(KYN)
pathway
is
influenced
by
inflammatory
mediators,
generating
metabolites
that
regulate
immune
and
responses.
Exercise
has
been
proposed
as
a
modulator
of
this
pathway,
but
its
role
in
health
benefits
chronic
disease
management
remains
unclear.
Objective
This
systematic
review
examines
exercise-induced
adaptations
KYN
their
potential
implications
for
management.
Additionally,
we
identify
key
methodological
considerations
future
research.
Methods
A
structured
search
PubMed/Medline,
Web
Science,
Scopus
was
conducted
up
to
October
2024
clinical
trials
investigating
effects
exercise
training
on
pathway.
Results
Of
2,795
articles
initially
found,
13
involving
592
participants
met
inclusion
criteria.
Most
studies
reported
particularly
cancer
survivors.
These
appeared
be
intensity
duration.
However,
several
limitations
were
noted,
no
included
patients
with
metabolic
or
cardiovascular
diseases.
Conclusions
Here,
show
modulates
both
healthy
diseased
populations,
highlighting
prevention
further
randomized-controlled
are
needed
clarify
mechanisms
applications,
Systematic
Review
Registration
https://www.crd.york.ac.uk/PROSPERO/view/CRD42022351481
,
PROSPERO
(CRD42022351481).
Язык: Английский
Unraveling lipopolysaccharide-induced behavioral and molecular effects in Lymnaea stagnalis, an emerging model organism for translational neuroscience
International Immunopharmacology,
Год журнала:
2025,
Номер
152, С. 114418 - 114418
Опубликована: Март 15, 2025
Язык: Английский
Physiological and pathophysiological effects of L-tryptophan’s metabolites on the brain and immunity – a challenge for drug development
Pharmacia,
Год журнала:
2025,
Номер
72, С. 1 - 7
Опубликована: Март 19, 2025
The
dysregulation
of
the
kynurenine
branch
from
tryptophan
(TRP)
metabolism
can
cause
an
imbalance
between
neuroprotective
kynurenic
acid
and
neurotoxic
metabolites
in
some
psychiatric
neurodegenerative
disorders.
Therefore,
modulation
TRP
may
contribute
to
novel
therapeutic
strategies
for
several
neuropsychiatric
diseases.
Targeting
L-TRP-kynurenine
pathway
enzymes,
particularly
involving
indoleamine
2,3-dioxygenase-1,
2,3-dioxygenase,
3-monooxygenase,
aminotransferase
II,
is
a
promising
approach.
future
development
potent
selective
inhibitors
these
enzymes
with
good
safety
profile
would
be
potential
new
avenue
treatment
many
essential
amino
L-Tryptophan,
together
its
metabolites,
plays
key
role
diverse
physiological
pathophysiological
processes
brain,
especially
disorders
autoimmunity.
Also,
vital
biochemical
precursor
functional
neuroactive
molecules,
including
serotonin
melatonin,
which
are
great
importance
memory
learning,
emotional
regulation,
circadian
cycle,
hunger,
pain,
etc.
This
article
aims
underscore
links
tryptophan’s
certain
diseases
central
nervous
system.
Язык: Английский
Mitigating effect of dietary tryptophan on intra-cohort cannibalism in tiger puffer (Takifugu rubripes) with clipped or intact teeth
Aquaculture,
Год журнала:
2025,
Номер
unknown, С. 742598 - 742598
Опубликована: Апрель 1, 2025
Язык: Английский
Role of Kynurenine and Its Derivatives in the Neuroimmune System
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7144 - 7144
Опубликована: Июнь 28, 2024
In
recent
years,
there
has
been
a
growing
realization
of
intricate
interactions
between
the
nervous
and
immune
systems,
characterized
by
shared
humoral
factors
receptors.
This
interplay
forms
basis
neuroimmune
system,
understanding
which
will
provide
insights
into
pathogenesis
neurological
diseases,
in
involvement
system
overlooked.
Kynurenine
its
derivatives
derived
from
tryptophan
have
long
implicated
various
diseases.
Recent
studies
revealed
their
close
association
not
only
with
disorders
but
also
sepsis-related
deaths.
review
provides
an
overview
biochemistry
kynurenine
derivatives,
followed
discussion
role
via
modulation
Язык: Английский
Novel machine learning investigation for Buongiorno fluidic model with Sutterby nanomaterial
Tribology International,
Год журнала:
2024,
Номер
199, С. 110009 - 110009
Опубликована: Июль 19, 2024
Язык: Английский
Metabolomics reveals the metabolic disturbance caused by arsenic in the mouse model of inflammatory bowel disease
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
287, С. 117305 - 117305
Опубликована: Ноя. 1, 2024
Arsenic
exposure
has
long
been
a
significant
global
health
concern
due
to
its
association
with
various
human
diseases.
The
adverse
effects
of
arsenic
can
be
influenced
by
multiple
factors,
resulting
in
considerable
individual
variability.
Individuals
inflammatory
bowel
disease
(IBD)
are
particularly
vulnerable
the
toxin
exposure,
yet
specific
impact
context
IBD
remains
unclear.
In
this
study,
we
employed
non-targeted
metabolomics
approach
investigate
how
affects
metabolic
homeostasis
an
model
using
Helicobacter
trogontum-infected
interleukin-10
deficient
mice.
Our
results
demonstrated
that
disrupted
balance
metabolites,
including
tryptophan,
polyunsaturated
fatty
acids,
purine
and
pyrimidine
branched-chain
amino
mice
colitis
but
not
those
without
colitis.
Notably,
several
crucial
metabolites
involved
anti-inflammatory
responses,
oxidative
stress,
energy
metabolism
were
significantly
altered
These
indicate
lead
extensive
disturbances,
potentially
exacerbating
severity
impacting
overall
health.
This
study
underscores
necessity
evaluating
toxicity
relation
better
understand
mitigate
associated
risks.
Язык: Английский